Asymmetrical and isolated hypoglossal nerve palsy accompanied by a new subset of anti-ganglioside antibodies in a patient with diffuse large b cell lymphoma

Yasuyuki Ohta, Yuko Kawahara, Koh Tadokoro, Kota Sato, Ryo Sasaki, Yoshiaki Takahashi, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Takeru Asano, Tomoko Inomata, Koji Abe

Research output: Contribution to journalArticle

Abstract

Malignant lymphoma sometimes involves peripheral nerves due to paraneoplastic syndrome associated with anti-ganglioside antibodies. We report a very rare case of malignant lymphoma accompanied by an asymmetrical and isolated hypoglossal nerve palsy associated with a new subset of anti-ganglioside antibodies. Magnetic resonance imaging and18F-2-deoxy-2-fluoro-D-glucose position emission tomography showed no abnormalities of the hypoglossal nerve nucleus; however, the patient’s serum was positive for anti-sulfated glucuro-nyl paragloboside IgM antibodies as well as anti-GM1 IgM and anti-GQ1b IgM antibodies. The present case might suggest a paraneoplastic asymmetrical and isolated hypoglossal nerve palsy associated with a new subset of anti-ganglioside antibodies.

Original languageEnglish
Pages (from-to)283-286
Number of pages4
JournalInternal Medicine
Volume58
Issue number2
DOIs
Publication statusPublished - Jan 15 2019

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Hypoglossal Nerve Diseases
Lymphoma, Large B-Cell, Diffuse
Gangliosides
Anti-Idiotypic Antibodies
Lymphoma
Hypoglossal Nerve
Paraneoplastic Syndromes
Antibodies
Fluorodeoxyglucose F18
Peripheral Nerves
Immunoglobulin M
Tomography
Magnetic Resonance Imaging
Serum
anti-IgM

Keywords

  • Anti-ganglioside antibody
  • Hypoglossal nerve palsy
  • Malignant lymphoma
  • Paraneoplastic syndrome

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Asymmetrical and isolated hypoglossal nerve palsy accompanied by a new subset of anti-ganglioside antibodies in a patient with diffuse large b cell lymphoma. / Ohta, Yasuyuki; Kawahara, Yuko; Tadokoro, Koh; Sato, Kota; Sasaki, Ryo; Takahashi, Yoshiaki; Takemoto, Mami; Hishikawa, Nozomi; Yamashita, Toru; Asano, Takeru; Inomata, Tomoko; Abe, Koji.

In: Internal Medicine, Vol. 58, No. 2, 15.01.2019, p. 283-286.

Research output: Contribution to journalArticle

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