Asymmetric Synthesis of Substituted Isoxazolidinone from α,β-Unsaturated Esters and Hydroxylamines by means of Double Stereodifferentiation

Teruhiko Ishikawa, Keita Nagai, Takayuki Kudoh, Seiki Saito

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Asymmetric synthesis of isoxazolidinones (1) has been developed by Michael addition and ensuing transesterification processes employing chiral hydroxylamines and α,β-unsaturated esters carrying chiral α-hydroxycarboxylic acid ester unit as an alkoxide moiety.

Original languageEnglish
Pages (from-to)1171-1173
Number of pages3
JournalSynlett
Volume1995
Issue number11
DOIs
Publication statusPublished - Nov 1995

Keywords

  • Chiral hydroxylamine
  • Double Stereodifferentiation
  • Isoxazolidinone
  • Michael addition
  • β-Amino acid synthon

ASJC Scopus subject areas

  • Organic Chemistry

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