Asymmetric synthesis of febrifugine and isofebrifugine using yeast reduction

Yasuo Takeuchi, K. Azuma, K. Takakura, H. Abe, T. Harayama

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Abstract

The antimalarial agents febrifugine ((+)-1) and isofebrifugine ((+)-2) were asymmetrically synthesized from chiral piperidin-3-ol ((+)-4), which was prepared by the reductive dynamic optical resolution of the 3-piperidone derivatives ((±)-3) using baker's yeast.

Original languageEnglish
Pages (from-to)1643-1644
Number of pages2
JournalChemical Communications
Issue number17
Publication statusPublished - Sep 7 2000

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ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Takeuchi, Y., Azuma, K., Takakura, K., Abe, H., & Harayama, T. (2000). Asymmetric synthesis of febrifugine and isofebrifugine using yeast reduction. Chemical Communications, (17), 1643-1644.