Asymmetric synthesis of (+)-febrifugine and (+)-isofebrifugine using yeast reduction

Yasuo Takeuchi, Kumiko Azuma, Kentaro Takakura, Hitoshi Abe, Hye Sook Kim, Yusuke Wataya, Takashi Harayama

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)

Abstract

The antimalarial agents febrifugine (D-1) and isofebrifugine (D-2) were synthesized from chiral 3-piperidinol (D-4), which was asymmetrically prepared by the yeast reduction of 3-piperidone derivatives (DL-3), with dynamic optical resolution.

Original languageEnglish
Pages (from-to)1213-1218
Number of pages6
JournalTetrahedron
Volume57
Issue number7
DOIs
Publication statusPublished - Feb 11 2001

Keywords

  • Antimalarial compounds
  • Asymmetric synthesis
  • Optical resolution
  • Reduction

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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