Asymmetric synthesis of cyclopropylmethanamines by rhodium-catalyzed cyclopropanation of pinacol allylboronate with N-sulfonyl-1,2,3-triazoles

Tomoya Miura, Takayuki Nakamuro, Hiroki Nikishima, Masahiro Murakami

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Herein, the rhodium(II)-catalyzed cyclopropanation reaction of pinacol allylboronate with N-sulfonyl-1,2,3-triazoles is reported. Boryl-substituted cyclopropylmethanamines are produced in a highly diastereo- and enantioselective manner. Various cyclopropylmethanamines containing a quaternary stereocenter are derived from them.

Original languageEnglish
Pages (from-to)1003-1005
Number of pages3
JournalChemistry Letters
Volume45
Issue number8
DOIs
Publication statusPublished - 2016
Externally publishedYes

Keywords

  • Cyclopropylmethanamine
  • Rhodium catalyst
  • Triazole

ASJC Scopus subject areas

  • Chemistry(all)

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