A novel synthetic route to enantiomerically pure 1-benzyltetrahydroisoquinolines (1) was developed via the reaction of oxazolo[2,3-a]tetrahydroisoquinoline (5) with benzyltriisopropoxytitanium compounds (10). This method was applied to the synthesis of (S)-trimetoquinol (lc; a bronchodilator).
- (S)-norarmepavine (S')-tetrahydropapaverine (5)-trimetoquinol asymmetric synthesis
- oxazolo[2,3-«]tetrahydroisoquinoline 1-benzyltetrahydroisoquinoline 1-chloroisochroman phenylglycinol
ASJC Scopus subject areas
- Drug Discovery