A novel synthetic route to enantiomerically pure 1-benzyltetrahydroisoquinolines (1) was developed via the reaction of oxazolo[2,3-a]tetrahydroisoquinoline (5) with benzyltriisopropoxytitanium compounds (10). This method was applied to the synthesis of (S)-trimetoquinol (1c; a bronchodilator).
|Number of pages||6|
|Journal||Chemical and Pharmaceutical Bulletin|
|Publication status||Published - 1991|
ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery