Asymmetric synthesis of 1-benzyltetrahydroisoquinolines using chiral oxazolo[2,3-a]tetrahydroisoquinolines

K. Hashigaki, K. Kan, N. Qais, Yasuo Takeuchi, M. Yamato

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A novel synthetic route to enantiomerically pure 1-benzyltetrahydroisoquinolines (1) was developed via the reaction of oxazolo[2,3-a]tetrahydroisoquinoline (5) with benzyltriisopropoxytitanium compounds (10). This method was applied to the synthesis of (S)-trimetoquinol (1c; a bronchodilator).

Original languageEnglish
Pages (from-to)1126-1131
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume39
Issue number5
Publication statusPublished - 1991

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Tretoquinol
Tetrahydroisoquinolines
Bronchodilator Agents

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Asymmetric synthesis of 1-benzyltetrahydroisoquinolines using chiral oxazolo[2,3-a]tetrahydroisoquinolines. / Hashigaki, K.; Kan, K.; Qais, N.; Takeuchi, Yasuo; Yamato, M.

In: Chemical and Pharmaceutical Bulletin, Vol. 39, No. 5, 1991, p. 1126-1131.

Research output: Contribution to journalArticle

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