Asymmetric synthesis of β-alkoxycyclic ethers via the intramolecular cyclization of group 14 allyls containing chiral acetals

Isao Kadota, Koichi Miura, Yoshinori Yamamoto

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Treatment of an allylic tin-bearing chiral acetal 1a with TiCl 4-PPh3 gives the (2S, 3R) isomer 2 with high diastereoselectivity (2 : 3 = 93 : 7), whereas the reaction of an allylic silane derivative 1f affords predominantly the (2R, 3S) isomer 3 (2 : 3 = 37 : 63).

Original languageEnglish
Pages (from-to)1953-1954
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number17
DOIs
Publication statusPublished - Dec 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine

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