Asymmetric Syntheses of 1-alkyltetrahydro-β-carbolines And A 9-Thio Analogue

Nazmul Qais; Noriyoshi Nakao; Kuniko Hashigaki; Yasuo Takeuchl; Masatoshi Yamato

doi:10.1248/cpb.39.3338

Asymmetric Syntheses of 1-alkyltetrahydro-β-carbolines And A 9-Thio Analogue

Nazmul Qais, Noriyoshi Nakao, Kuniko Hashigaki, Yasuo Takeuchl, Masatoshi Yamato

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Tetrahydro-β-carbolines, (S)-tetrahydroharman (8a) and (S)-1-phenyltetrahydro-β-carboline (8b), were asymmetrically synthesized starting from (R)-phenylglycinol and 1-benzy1-3-(2-bromoethy)indole (1). Asymmetric synthesis of the 9-thio analogue (15) of 8a was also achieved.

Original language	English
Pages (from-to)	3338-3340
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	39
Issue number	12
DOIs	https://doi.org/10.1248/cpb.39.3338
Publication status	Published - 1991

Keywords

3-c]pyridine phenylglycinol asymmetric synthesis
5]thieno[2
carboline (S)-tetrahydroharman (S)-aryltetrahydro-β
carboline tetrahydroberfzo[4
tetrahydro-β

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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title = "Asymmetric Syntheses of 1-alkyltetrahydro-β-carbolines And A 9-Thio Analogue",

abstract = "Tetrahydro-β-carbolines, (S)-tetrahydroharman (8a) and (S)-1-phenyltetrahydro-β-carboline (8b), were asymmetrically synthesized starting from (R)-phenylglycinol and 1-benzy1-3-(2-bromoethy)indole (1). Asymmetric synthesis of the 9-thio analogue (15) of 8a was also achieved.",

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year = "1991",

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T1 - Asymmetric Syntheses of 1-alkyltetrahydro-β-carbolines And A 9-Thio Analogue

AU - Qais, Nazmul

AU - Nakao, Noriyoshi

AU - Hashigaki, Kuniko

AU - Takeuchl, Yasuo

AU - Yamato, Masatoshi

PY - 1991

Y1 - 1991

N2 - Tetrahydro-β-carbolines, (S)-tetrahydroharman (8a) and (S)-1-phenyltetrahydro-β-carboline (8b), were asymmetrically synthesized starting from (R)-phenylglycinol and 1-benzy1-3-(2-bromoethy)indole (1). Asymmetric synthesis of the 9-thio analogue (15) of 8a was also achieved.

AB - Tetrahydro-β-carbolines, (S)-tetrahydroharman (8a) and (S)-1-phenyltetrahydro-β-carboline (8b), were asymmetrically synthesized starting from (R)-phenylglycinol and 1-benzy1-3-(2-bromoethy)indole (1). Asymmetric synthesis of the 9-thio analogue (15) of 8a was also achieved.

KW - 3-c]pyridine phenylglycinol asymmetric synthesis

KW - 5]thieno[2

KW - carboline (S)-tetrahydroharman (S)-aryltetrahydro-β

KW - carboline tetrahydroberfzo[4

KW - tetrahydro-β

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