Asymmetric syntheses of 1-alkyltetrahydro-β-carbolines and a 9-thio analogue

N. Qais, N. Nakao, K. Hashigaki, Yasuo Takeuchi, M. Yamato

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Tetrahydro-β-carbolines, (S)-tetrahydroharman (8a) and (S)-1-phenyltetrahydro-β-carboline (8b), were asymmetrically synthesized starting from (R)-phenylglycinol and 1-benzyl-3-(2-bromoethyl)indole (1). Asymmetric synthesis of the 9-thio analogue (15) of 8a was also achieved.

Original languageEnglish
Pages (from-to)3338-3340
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume39
Issue number12
Publication statusPublished - 1991

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Carbolines
tetrahydroharmane
N-phenylethanolamine
indole
3-(2-bromoethyl)indole

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Asymmetric syntheses of 1-alkyltetrahydro-β-carbolines and a 9-thio analogue. / Qais, N.; Nakao, N.; Hashigaki, K.; Takeuchi, Yasuo; Yamato, M.

In: Chemical and Pharmaceutical Bulletin, Vol. 39, No. 12, 1991, p. 3338-3340.

Research output: Contribution to journalArticle

Qais, N, Nakao, N, Hashigaki, K, Takeuchi, Y & Yamato, M 1991, 'Asymmetric syntheses of 1-alkyltetrahydro-β-carbolines and a 9-thio analogue', Chemical and Pharmaceutical Bulletin, vol. 39, no. 12, pp. 3338-3340.
Qais, N. ; Nakao, N. ; Hashigaki, K. ; Takeuchi, Yasuo ; Yamato, M. / Asymmetric syntheses of 1-alkyltetrahydro-β-carbolines and a 9-thio analogue. In: Chemical and Pharmaceutical Bulletin. 1991 ; Vol. 39, No. 12. pp. 3338-3340.
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