Asymmetric Syntheses of 1-alkyltetrahydro-β-carbolines And A 9-Thio Analogue

Nazmul Qais, Noriyoshi Nakao, Kuniko Hashigaki, Yasuo Takeuchl, Masatoshi Yamato

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Tetrahydro-β-carbolines, (S)-tetrahydroharman (8a) and (S)-1-phenyltetrahydro-β-carboline (8b), were asymmetrically synthesized starting from (R)-phenylglycinol and 1-benzy1-3-(2-bromoethy)indole (1). Asymmetric synthesis of the 9-thio analogue (15) of 8a was also achieved.

Original languageEnglish
Pages (from-to)3338-3340
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Issue number12
Publication statusPublished - 1991


  • 3-c]pyridine phenylglycinol asymmetric synthesis
  • 5]thieno[2
  • carboline (S)-tetrahydroharman (S)-aryltetrahydro-β
  • carboline tetrahydroberfzo[4
  • tetrahydro-β

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery


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