Asymmetric Syntheses of 1-alkyltetrahydro-β-carbolines And A 9-Thio Analogue

Nazmul Qais; Noriyoshi Nakao; Kuniko Hashigaki; Yasuo Takeuchl; Masatoshi Yamato

doi:10.1248/cpb.39.3338

Asymmetric Syntheses of 1-alkyltetrahydro-β-carbolines And A 9-Thio Analogue

Nazmul Qais, Noriyoshi Nakao, Kuniko Hashigaki, Yasuo Takeuchl, Masatoshi Yamato

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Tetrahydro-β-carbolines, (S)-tetrahydroharman (8a) and (S)-1-phenyltetrahydro-β-carboline (8b), were asymmetrically synthesized starting from (R)-phenylglycinol and 1-benzy1-3-(2-bromoethy)indole (1). Asymmetric synthesis of the 9-thio analogue (15) of 8a was also achieved.

Original language	English
Pages (from-to)	3338-3340
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	39
Issue number	12
DOIs	https://doi.org/10.1248/cpb.39.3338
Publication status	Published - 1991

Keywords

3-c]pyridine phenylglycinol asymmetric synthesis
5]thieno[2
carboline (S)-tetrahydroharman (S)-aryltetrahydro-β
carboline tetrahydroberfzo[4
tetrahydro-β

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

Access to Document

10.1248/cpb.39.3338

Cite this

@article{fd55b3aa27f4425da3e375d1e7f9ea55,

title = "Asymmetric Syntheses of 1-alkyltetrahydro-β-carbolines And A 9-Thio Analogue",

abstract = "Tetrahydro-β-carbolines, (S)-tetrahydroharman (8a) and (S)-1-phenyltetrahydro-β-carboline (8b), were asymmetrically synthesized starting from (R)-phenylglycinol and 1-benzy1-3-(2-bromoethy)indole (1). Asymmetric synthesis of the 9-thio analogue (15) of 8a was also achieved.",

keywords = "3-c]pyridine phenylglycinol asymmetric synthesis, 5]thieno[2, carboline (S)-tetrahydroharman (S)-aryltetrahydro-β, carboline tetrahydroberfzo[4, tetrahydro-β",

author = "Nazmul Qais and Noriyoshi Nakao and Kuniko Hashigaki and Yasuo Takeuchl and Masatoshi Yamato",

year = "1991",

doi = "10.1248/cpb.39.3338",

language = "English",

volume = "39",

pages = "3338--3340",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

number = "12",

}

TY - JOUR

T1 - Asymmetric Syntheses of 1-alkyltetrahydro-β-carbolines And A 9-Thio Analogue

AU - Qais, Nazmul

AU - Nakao, Noriyoshi

AU - Hashigaki, Kuniko

AU - Takeuchl, Yasuo

AU - Yamato, Masatoshi

PY - 1991

Y1 - 1991

N2 - Tetrahydro-β-carbolines, (S)-tetrahydroharman (8a) and (S)-1-phenyltetrahydro-β-carboline (8b), were asymmetrically synthesized starting from (R)-phenylglycinol and 1-benzy1-3-(2-bromoethy)indole (1). Asymmetric synthesis of the 9-thio analogue (15) of 8a was also achieved.

AB - Tetrahydro-β-carbolines, (S)-tetrahydroharman (8a) and (S)-1-phenyltetrahydro-β-carboline (8b), were asymmetrically synthesized starting from (R)-phenylglycinol and 1-benzy1-3-(2-bromoethy)indole (1). Asymmetric synthesis of the 9-thio analogue (15) of 8a was also achieved.

KW - 3-c]pyridine phenylglycinol asymmetric synthesis

KW - 5]thieno[2

KW - carboline (S)-tetrahydroharman (S)-aryltetrahydro-β

KW - carboline tetrahydroberfzo[4

KW - tetrahydro-β

UR - http://www.scopus.com/inward/record.url?scp=0026344213&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026344213&partnerID=8YFLogxK

U2 - 10.1248/cpb.39.3338

DO - 10.1248/cpb.39.3338

M3 - Article

AN - SCOPUS:0026344213

VL - 39

SP - 3338

EP - 3340

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 12

ER -

Asymmetric Syntheses of 1-alkyltetrahydro-β-carbolines And A 9-Thio Analogue

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this