Abstract
Seven fungi, which are found to reduce ethyl 3-oxobutanoate in high yields, were tested for their reducing ability for ethyl 2-methyl 3-oxobutanoate. We obtained some interesting findings. In particular, Penicillium purpurogenum reduced ethyl 2-methyl 3-oxobutanoate to the corresponding alcohols with the diastereomer (anti/syn) ratio of 93/7 with the enantiomeric excess of anti-(2S, 3S)- and syn-(2S, 3R)-hydroxy esters of 90 and >99ee%, respectively.
Original language | English |
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Pages (from-to) | 194-197 |
Number of pages | 4 |
Journal | Bioscience, Biotechnology and Biochemistry |
Volume | 64 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2000 |
Externally published | Yes |
Keywords
- (2S, 3R)-ethyl 2-methyl 3-hydroxybutanoate
- (2S, 3S)-ethyl 2-methyl 3-hydroxybutanoate
- Asymmetric reduction
- Ethyl 2-methyl 3-oxobutanoate
- Penicillium purpurogenum
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry