Asymmetric reduction of ethyl 2-methyl 3-oxobutanoate by fungi

Kenzo Iwamoto, Takayuki Kuramoto, Minoru Izumi, Mitsunori Kirihata, Takaaki Dohmaru, Fumiki Yoshizako

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Seven fungi, which are found to reduce ethyl 3-oxobutanoate in high yields, were tested for their reducing ability for ethyl 2-methyl 3-oxobutanoate. We obtained some interesting findings. In particular, Penicillium purpurogenum reduced ethyl 2-methyl 3-oxobutanoate to the corresponding alcohols with the diastereomer (anti/syn) ratio of 93/7 with the enantiomeric excess of anti-(2S, 3S)- and syn-(2S, 3R)-hydroxy esters of 90 and >99ee%, respectively.

Original languageEnglish
Pages (from-to)194-197
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume64
Issue number1
DOIs
Publication statusPublished - Jan 2000
Externally publishedYes

Keywords

  • (2S, 3R)-ethyl 2-methyl 3-hydroxybutanoate
  • (2S, 3S)-ethyl 2-methyl 3-hydroxybutanoate
  • Asymmetric reduction
  • Ethyl 2-methyl 3-oxobutanoate
  • Penicillium purpurogenum

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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