Abstract
Seven fungi, which are found to reduce ethyl 3-oxobutanoate in high yields, were tested for their reducing ability for ethyl 2-methyl 3-oxobutanoate. We obtained some interesting findings. In particular, Penicillium purpurogenum reduced ethyl 2-methyl 3-oxobutanoate to the corresponding alcohols with the diastereomer (anti/syn) ratio of 93/7 with the enantiomeric excess of anti-(2S, 3S)- and syn-(2S, 3R)-hydroxy esters of 90 and >99ee%, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 194-197 |
| Number of pages | 4 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 64 |
| Issue number | 1 |
| Publication status | Published - Jan 2000 |
| Externally published | Yes |
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Keywords
- (2S, 3R)-ethyl 2-methyl 3-hydroxybutanoate
- (2S, 3S)-ethyl 2-methyl 3-hydroxybutanoate
- Asymmetric reduction
- Ethyl 2-methyl 3-oxobutanoate
- Penicillium purpurogenum
ASJC Scopus subject areas
- Food Science
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Biotechnology
- Chemistry (miscellaneous)
- Applied Microbiology and Biotechnology
- Bioengineering
Cite this
Asymmetric reduction of ethyl 2-methyl 3-oxobutanoate by fungi. / Iwamoto, Kenzo; Kuramoto, Takayuki; Izumi, Minoru; Kirihata, Mitsunori; Dohmaru, Takaaki; Yoshizako, Fumiki.
In: Bioscience, Biotechnology and Biochemistry, Vol. 64, No. 1, 01.2000, p. 194-197.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Asymmetric reduction of ethyl 2-methyl 3-oxobutanoate by fungi
AU - Iwamoto, Kenzo
AU - Kuramoto, Takayuki
AU - Izumi, Minoru
AU - Kirihata, Mitsunori
AU - Dohmaru, Takaaki
AU - Yoshizako, Fumiki
PY - 2000/1
Y1 - 2000/1
N2 - Seven fungi, which are found to reduce ethyl 3-oxobutanoate in high yields, were tested for their reducing ability for ethyl 2-methyl 3-oxobutanoate. We obtained some interesting findings. In particular, Penicillium purpurogenum reduced ethyl 2-methyl 3-oxobutanoate to the corresponding alcohols with the diastereomer (anti/syn) ratio of 93/7 with the enantiomeric excess of anti-(2S, 3S)- and syn-(2S, 3R)-hydroxy esters of 90 and >99ee%, respectively.
AB - Seven fungi, which are found to reduce ethyl 3-oxobutanoate in high yields, were tested for their reducing ability for ethyl 2-methyl 3-oxobutanoate. We obtained some interesting findings. In particular, Penicillium purpurogenum reduced ethyl 2-methyl 3-oxobutanoate to the corresponding alcohols with the diastereomer (anti/syn) ratio of 93/7 with the enantiomeric excess of anti-(2S, 3S)- and syn-(2S, 3R)-hydroxy esters of 90 and >99ee%, respectively.
KW - (2S, 3R)-ethyl 2-methyl 3-hydroxybutanoate
KW - (2S, 3S)-ethyl 2-methyl 3-hydroxybutanoate
KW - Asymmetric reduction
KW - Ethyl 2-methyl 3-oxobutanoate
KW - Penicillium purpurogenum
UR - http://www.scopus.com/inward/record.url?scp=0033644595&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033644595&partnerID=8YFLogxK
M3 - Article
C2 - 10766507
AN - SCOPUS:0033644595
VL - 64
SP - 194
EP - 197
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
SN - 0916-8451
IS - 1
ER -