Abstract
Seven fungi, which are found to reduce ethyl 3-oxobutanoate in high yields, were tested for their reducing ability for ethyl 2-methyl 3-oxobutanoate. We obtained some interesting findings. In particular, Penicillium purpurogenum reduced ethyl 2-methyl 3-oxobutanoate to the corresponding alcohols with the diastereomer (anti/syn) ratio of 93/7 with the enantiomeric excess of anti-(2S, 3S)- and syn-(2S, 3R)-hydroxy esters of 90 and >99ee%, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 194-197 |
| Number of pages | 4 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 64 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2000 |
| Externally published | Yes |
Keywords
- (2S, 3R)-ethyl 2-methyl 3-hydroxybutanoate
- (2S, 3S)-ethyl 2-methyl 3-hydroxybutanoate
- Asymmetric reduction
- Ethyl 2-methyl 3-oxobutanoate
- Penicillium purpurogenum
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry
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Cite this
Iwamoto, K., Kuramoto, T., Izumi, M., Kirihata, M., Dohmaru, T., & Yoshizako, F. (2000). Asymmetric reduction of ethyl 2-methyl 3-oxobutanoate by fungi. Bioscience, Biotechnology and Biochemistry, 64(1), 194-197. https://doi.org/10.1271/bbb.64.194