Asymmetric reduction of ethyl 2-methyl 3-oxobutanoate by fungi

Kenzo Iwamoto, Takayuki Kuramoto, Minoru Izumi, Mitsunori Kirihata, Takaaki Dohmaru, Fumiki Yoshizako

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Seven fungi, which are found to reduce ethyl 3-oxobutanoate in high yields, were tested for their reducing ability for ethyl 2-methyl 3-oxobutanoate. We obtained some interesting findings. In particular, Penicillium purpurogenum reduced ethyl 2-methyl 3-oxobutanoate to the corresponding alcohols with the diastereomer (anti/syn) ratio of 93/7 with the enantiomeric excess of anti-(2S, 3S)- and syn-(2S, 3R)-hydroxy esters of 90 and >99ee%, respectively.

Original languageEnglish
Pages (from-to)194-197
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume64
Issue number1
Publication statusPublished - Jan 2000
Externally publishedYes

Fingerprint

Talaromyces purpurogenus
diastereomers
Fungi
Esters
Alcohols
alcohols
esters
fungi
Penicillium
ethyl 2-methyl-3-oxobutanoate

Keywords

  • (2S, 3R)-ethyl 2-methyl 3-hydroxybutanoate
  • (2S, 3S)-ethyl 2-methyl 3-hydroxybutanoate
  • Asymmetric reduction
  • Ethyl 2-methyl 3-oxobutanoate
  • Penicillium purpurogenum

ASJC Scopus subject areas

  • Food Science
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biotechnology
  • Chemistry (miscellaneous)
  • Applied Microbiology and Biotechnology
  • Bioengineering

Cite this

Iwamoto, K., Kuramoto, T., Izumi, M., Kirihata, M., Dohmaru, T., & Yoshizako, F. (2000). Asymmetric reduction of ethyl 2-methyl 3-oxobutanoate by fungi. Bioscience, Biotechnology and Biochemistry, 64(1), 194-197.

Asymmetric reduction of ethyl 2-methyl 3-oxobutanoate by fungi. / Iwamoto, Kenzo; Kuramoto, Takayuki; Izumi, Minoru; Kirihata, Mitsunori; Dohmaru, Takaaki; Yoshizako, Fumiki.

In: Bioscience, Biotechnology and Biochemistry, Vol. 64, No. 1, 01.2000, p. 194-197.

Research output: Contribution to journalArticle

Iwamoto, K, Kuramoto, T, Izumi, M, Kirihata, M, Dohmaru, T & Yoshizako, F 2000, 'Asymmetric reduction of ethyl 2-methyl 3-oxobutanoate by fungi', Bioscience, Biotechnology and Biochemistry, vol. 64, no. 1, pp. 194-197.
Iwamoto K, Kuramoto T, Izumi M, Kirihata M, Dohmaru T, Yoshizako F. Asymmetric reduction of ethyl 2-methyl 3-oxobutanoate by fungi. Bioscience, Biotechnology and Biochemistry. 2000 Jan;64(1):194-197.
Iwamoto, Kenzo ; Kuramoto, Takayuki ; Izumi, Minoru ; Kirihata, Mitsunori ; Dohmaru, Takaaki ; Yoshizako, Fumiki. / Asymmetric reduction of ethyl 2-methyl 3-oxobutanoate by fungi. In: Bioscience, Biotechnology and Biochemistry. 2000 ; Vol. 64, No. 1. pp. 194-197.
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