Abstract
Chlorella pyrenoidosa Chick reduced ethyl 2-methyl 3-oxobutanoate to the corresponding alcohols with the diastereomer (anti/syn) ratio of 53/47. The enantiomer excesses of anti-(2S, 3S)- and syn-(2S, 3R)-hydroxy esters were 89 and >99ee% respectively. C. vulgaris and C. regularis afforded predominantly the syn-isomer, contrary to C. pyrenoidosa. The differences in the activity of reducing ethyl 2-methyl 3-oxobutanoate were observed among three strains of Chlorella. Addition of 2% metal salts slightly increased the chemical yield of the hydroxy ester.
| Original language | English |
|---|---|
| Pages (from-to) | 598-601 |
| Number of pages | 4 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 63 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jan 1 1999 |
| Externally published | Yes |
Keywords
- (2S, 3R)-ethyl 2-methyl 3-hydroxybutanoate
- (2S, 3S)-ethyl 2-methyl 3-hydroxybutanoate
- Asymmetric reduction
- Chlorella
- Ethyl 2-methyl 3-oxobutanoate
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry