Astrocytic tau pathologies in argyrophilic grain disease and related four-repeat tauopathies

Chikako Ikeda, Osamu Yokota, Tomoko Miki, Shintaro Takenoshita, Hideki Ishizu, Seishi Terada, Norihito Yamada

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Neurodegenerative diseases in which tau accumulation plays a cardinal role in the pathogenic process are called tauopathies, and when tau isoforms having four repeats of the microtubule binding sites, four-repeat tau, are selectively accumulated as pathological hallmarks, the term four-repeat tauopathy is used. The major four-repeat tauopathies are progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and argyrophilic grain disease (AGD). Historically, neuronal cytopathologies, e.g., neurofibrillary tangles and ballooned neurons, were emphasized as characteristic lesions in PSP and CBD. Now, however, astrocytic tau pathologies, i.e., tufted astrocytes (TAs) and astrocytic plaques (APs), are considered to be highly disease-specific lesions. Although granular/fuzzy astrocytes (GFAs) frequently develop in the limbic system in AGD cases, the specificity is not conclusive yet. Some AGD cases have a few TAs, and to a lesser frequency, a few APs in the frontal cortex and subcortical nuclei. The number of astrocytic tau pathologies including TAs and GFAs increases with the progression of AGD. In this paper, histopathological features of astrocytic tau pathologies in PSP, CBD, and AGD are first reviewed. Then, recent findings regarding the coexistence of these tauopathies are summarized from a viewpoint of astrocytic tau pathologies. Further biochemical and pathological studies focusing tau-positive astrocytic lesions may be useful to increase understanding of the pathological process in four-repeat tauopathies and to develop novel therapeutic strategies for patients with these diseases.

Original languageEnglish
Pages (from-to)211-221
Number of pages11
JournalActa Medica Okayama
Volume72
Issue number3
Publication statusPublished - Jan 1 2018

Fingerprint

Tauopathies
Pathology
Astrocytes
Progressive Supranuclear Palsy
Neurodegenerative diseases
Limbic System
Neurofibrillary Tangles
Frontal Lobe
Pathologic Processes
Microtubules
Neurodegenerative Diseases
Neurons
Protein Isoforms
Binding Sites

Keywords

  • Astrocytic plaque
  • Four-repeat tau
  • Globular glial inclusion
  • Granular fuzzy astrocyte
  • Tufted astrocyte

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Astrocytic tau pathologies in argyrophilic grain disease and related four-repeat tauopathies. / Ikeda, Chikako; Yokota, Osamu; Miki, Tomoko; Takenoshita, Shintaro; Ishizu, Hideki; Terada, Seishi; Yamada, Norihito.

In: Acta Medica Okayama, Vol. 72, No. 3, 01.01.2018, p. 211-221.

Research output: Contribution to journalReview article

Ikeda, C, Yokota, O, Miki, T, Takenoshita, S, Ishizu, H, Terada, S & Yamada, N 2018, 'Astrocytic tau pathologies in argyrophilic grain disease and related four-repeat tauopathies', Acta Medica Okayama, vol. 72, no. 3, pp. 211-221.
Ikeda C, Yokota O, Miki T, Takenoshita S, Ishizu H, Terada S et al. Astrocytic tau pathologies in argyrophilic grain disease and related four-repeat tauopathies. Acta Medica Okayama. 2018 Jan 1;72(3):211-221.
Ikeda, Chikako ; Yokota, Osamu ; Miki, Tomoko ; Takenoshita, Shintaro ; Ishizu, Hideki ; Terada, Seishi ; Yamada, Norihito. / Astrocytic tau pathologies in argyrophilic grain disease and related four-repeat tauopathies. In: Acta Medica Okayama. 2018 ; Vol. 72, No. 3. pp. 211-221.
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