Asthma classification by pathophysiology and IgE-mediated allergic reaction: new concepts for classification of asthma.

Y. Tanizaki, H. Kitani, M. Okazaki, T. Mifune, Fumihiro Mitsunobu, N. Honke, Y. Kusaura, I. Kimura

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Bronchial asthma was classified by the pathophysiology and by the mechanism of onset of the disease. Forty asthmatics who had serum IgE levels lower than 200 IU/ml were evaluated by two classification methods. 1. In asthma classified by a score based on clinical findings and examinations, the characteristics of the findings and examination results were compared among three asthma types, i.e., Ia. simple broncho-constriction type, Ib. bronchoconstriction+hypersecretion type, and II. bronchiolar obstruction type. Type Ib patients, in addition to manifesting hypersecretion, had a significantly higher proportion of eosinophils in the bronchoalveolar lavage (BAL) fluid compared to other asthma types. Significantly decreased values for ventilatory parameters and an increased proportion of BAL neutrophils were found in type II compared with other asthma types. 2. In a new classification by mechanism of onset, asthma was classified into three types according to the degree of participation of IgE-mediated reactions associated with specific IgE antibodies and serum levels of total IgE: asthma induced by definite IgE-mediated reaction (atopic asthma), possible IgE-mediated reactions (asthma), and asthma induced by non-IgE-mediated reaction (asthma syndrome).

Original languageEnglish
Pages (from-to)381-387
Number of pages7
JournalActa Medica Okayama
Volume46
Issue number5
Publication statusPublished - Oct 1992

Fingerprint

Immunoglobulin E
Hypersensitivity
Asthma
Bronchoconstriction
Bronchoalveolar Lavage Fluid
Fluids
Bronchoalveolar Lavage
Antibodies
Serum
Eosinophils
Constriction
Neutrophils

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Tanizaki, Y., Kitani, H., Okazaki, M., Mifune, T., Mitsunobu, F., Honke, N., ... Kimura, I. (1992). Asthma classification by pathophysiology and IgE-mediated allergic reaction: new concepts for classification of asthma. Acta Medica Okayama, 46(5), 381-387.

Asthma classification by pathophysiology and IgE-mediated allergic reaction : new concepts for classification of asthma. / Tanizaki, Y.; Kitani, H.; Okazaki, M.; Mifune, T.; Mitsunobu, Fumihiro; Honke, N.; Kusaura, Y.; Kimura, I.

In: Acta Medica Okayama, Vol. 46, No. 5, 10.1992, p. 381-387.

Research output: Contribution to journalArticle

Tanizaki, Y, Kitani, H, Okazaki, M, Mifune, T, Mitsunobu, F, Honke, N, Kusaura, Y & Kimura, I 1992, 'Asthma classification by pathophysiology and IgE-mediated allergic reaction: new concepts for classification of asthma.', Acta Medica Okayama, vol. 46, no. 5, pp. 381-387.
Tanizaki, Y. ; Kitani, H. ; Okazaki, M. ; Mifune, T. ; Mitsunobu, Fumihiro ; Honke, N. ; Kusaura, Y. ; Kimura, I. / Asthma classification by pathophysiology and IgE-mediated allergic reaction : new concepts for classification of asthma. In: Acta Medica Okayama. 1992 ; Vol. 46, No. 5. pp. 381-387.
@article{59068a06dbda4054882ca42843173fac,
title = "Asthma classification by pathophysiology and IgE-mediated allergic reaction: new concepts for classification of asthma.",
abstract = "Bronchial asthma was classified by the pathophysiology and by the mechanism of onset of the disease. Forty asthmatics who had serum IgE levels lower than 200 IU/ml were evaluated by two classification methods. 1. In asthma classified by a score based on clinical findings and examinations, the characteristics of the findings and examination results were compared among three asthma types, i.e., Ia. simple broncho-constriction type, Ib. bronchoconstriction+hypersecretion type, and II. bronchiolar obstruction type. Type Ib patients, in addition to manifesting hypersecretion, had a significantly higher proportion of eosinophils in the bronchoalveolar lavage (BAL) fluid compared to other asthma types. Significantly decreased values for ventilatory parameters and an increased proportion of BAL neutrophils were found in type II compared with other asthma types. 2. In a new classification by mechanism of onset, asthma was classified into three types according to the degree of participation of IgE-mediated reactions associated with specific IgE antibodies and serum levels of total IgE: asthma induced by definite IgE-mediated reaction (atopic asthma), possible IgE-mediated reactions (asthma), and asthma induced by non-IgE-mediated reaction (asthma syndrome).",
author = "Y. Tanizaki and H. Kitani and M. Okazaki and T. Mifune and Fumihiro Mitsunobu and N. Honke and Y. Kusaura and I. Kimura",
year = "1992",
month = "10",
language = "English",
volume = "46",
pages = "381--387",
journal = "Acta Medica Okayama",
issn = "0386-300X",
publisher = "Okayama University",
number = "5",

}

TY - JOUR

T1 - Asthma classification by pathophysiology and IgE-mediated allergic reaction

T2 - new concepts for classification of asthma.

AU - Tanizaki, Y.

AU - Kitani, H.

AU - Okazaki, M.

AU - Mifune, T.

AU - Mitsunobu, Fumihiro

AU - Honke, N.

AU - Kusaura, Y.

AU - Kimura, I.

PY - 1992/10

Y1 - 1992/10

N2 - Bronchial asthma was classified by the pathophysiology and by the mechanism of onset of the disease. Forty asthmatics who had serum IgE levels lower than 200 IU/ml were evaluated by two classification methods. 1. In asthma classified by a score based on clinical findings and examinations, the characteristics of the findings and examination results were compared among three asthma types, i.e., Ia. simple broncho-constriction type, Ib. bronchoconstriction+hypersecretion type, and II. bronchiolar obstruction type. Type Ib patients, in addition to manifesting hypersecretion, had a significantly higher proportion of eosinophils in the bronchoalveolar lavage (BAL) fluid compared to other asthma types. Significantly decreased values for ventilatory parameters and an increased proportion of BAL neutrophils were found in type II compared with other asthma types. 2. In a new classification by mechanism of onset, asthma was classified into three types according to the degree of participation of IgE-mediated reactions associated with specific IgE antibodies and serum levels of total IgE: asthma induced by definite IgE-mediated reaction (atopic asthma), possible IgE-mediated reactions (asthma), and asthma induced by non-IgE-mediated reaction (asthma syndrome).

AB - Bronchial asthma was classified by the pathophysiology and by the mechanism of onset of the disease. Forty asthmatics who had serum IgE levels lower than 200 IU/ml were evaluated by two classification methods. 1. In asthma classified by a score based on clinical findings and examinations, the characteristics of the findings and examination results were compared among three asthma types, i.e., Ia. simple broncho-constriction type, Ib. bronchoconstriction+hypersecretion type, and II. bronchiolar obstruction type. Type Ib patients, in addition to manifesting hypersecretion, had a significantly higher proportion of eosinophils in the bronchoalveolar lavage (BAL) fluid compared to other asthma types. Significantly decreased values for ventilatory parameters and an increased proportion of BAL neutrophils were found in type II compared with other asthma types. 2. In a new classification by mechanism of onset, asthma was classified into three types according to the degree of participation of IgE-mediated reactions associated with specific IgE antibodies and serum levels of total IgE: asthma induced by definite IgE-mediated reaction (atopic asthma), possible IgE-mediated reactions (asthma), and asthma induced by non-IgE-mediated reaction (asthma syndrome).

UR - http://www.scopus.com/inward/record.url?scp=0026941123&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026941123&partnerID=8YFLogxK

M3 - Article

C2 - 1442158

AN - SCOPUS:0026941123

VL - 46

SP - 381

EP - 387

JO - Acta Medica Okayama

JF - Acta Medica Okayama

SN - 0386-300X

IS - 5

ER -