Abstract
Retinol, α-tocopherol, and γ-tocopherol are fat-soluble vitamins acting as antioxidants via the prevention of lipid oxidation. Little is known about circulatory levels in healthy individuals. The present cross-sectional study aimed at elucidating the relationship between these antioxidants and clinical biomarkers in 206 male (median age 41 years, range 23-67) employees from companies located in the Okayama Prefecture, Japan. Subjects younger than 40 years (n = 94) showed a positive association of the frequency of alcohol consumption with the circulating retinol (β = 0.344, p = 0.001) and γ-tocopherol levels (β = 0.219, p = 0.041), and an inverse association of fast insulin with serum retinol (β = &-*0.301, p = 0.009). In participants older than 40 years (n = 112) we found that an inverse association of HOMA-R with serum retinol (β = &-*0.262, p = 0.021), α-tocopherol (β = &-*0.236, p = 0.035), and γ-tocopherol levels (β = &-*0.224, p = 0.052); and cigarette smoking was inversely associated with the levels of serum α-tocopherol (β = &-*0.286, p = 0.008) and γ-tocopherol (β = &-*0.229, p = 0.040). We further found negative relationships between serum ferritin and the retinol (β = &-*0.211, p = 0.032) and α-tocopherol levels (β = &-*0.223, p = 0.022) in men over 40 years of age. The present study suggests that the circulatory levels of antioxidant vitamins may modulate the action of insulin and that higher levels of iron might decrease the levels of antioxidant vitamins in the blood.
| Original language | English |
|---|---|
| Pages (from-to) | 1647-1660 |
| Number of pages | 14 |
| Journal | International Journal of Environmental Research and Public Health |
| Volume | 11 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 30 2014 |
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Keywords
- Alcohol consumption
- Homa-r
- Serum α-tocopherol
- Serum γ-tocopherol
- Serum ferritin
- Serum retinol
- Smoking
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis
- Medicine(all)
Cite this
Associations of serum retinol, α-tocopherol, and γ-tocopherol with biomarkers among healthy Japanese men. / Zou, Yu; Wang, Da Hong; Sakano, Noriko; Sato, Yoshie; Iwanaga, Suketaka; Taketa, Kazuhisa; Kubo, Masayuki; Takemoto, Kei; Masatomi, Chie; Inoue, Kiyomi; Ogino, Keiki.
In: International Journal of Environmental Research and Public Health, Vol. 11, No. 2, 30.01.2014, p. 1647-1660.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Associations of serum retinol, α-tocopherol, and γ-tocopherol with biomarkers among healthy Japanese men
AU - Zou, Yu
AU - Wang, Da Hong
AU - Sakano, Noriko
AU - Sato, Yoshie
AU - Iwanaga, Suketaka
AU - Taketa, Kazuhisa
AU - Kubo, Masayuki
AU - Takemoto, Kei
AU - Masatomi, Chie
AU - Inoue, Kiyomi
AU - Ogino, Keiki
PY - 2014/1/30
Y1 - 2014/1/30
N2 - Retinol, α-tocopherol, and γ-tocopherol are fat-soluble vitamins acting as antioxidants via the prevention of lipid oxidation. Little is known about circulatory levels in healthy individuals. The present cross-sectional study aimed at elucidating the relationship between these antioxidants and clinical biomarkers in 206 male (median age 41 years, range 23-67) employees from companies located in the Okayama Prefecture, Japan. Subjects younger than 40 years (n = 94) showed a positive association of the frequency of alcohol consumption with the circulating retinol (β = 0.344, p = 0.001) and γ-tocopherol levels (β = 0.219, p = 0.041), and an inverse association of fast insulin with serum retinol (β = &-*0.301, p = 0.009). In participants older than 40 years (n = 112) we found that an inverse association of HOMA-R with serum retinol (β = &-*0.262, p = 0.021), α-tocopherol (β = &-*0.236, p = 0.035), and γ-tocopherol levels (β = &-*0.224, p = 0.052); and cigarette smoking was inversely associated with the levels of serum α-tocopherol (β = &-*0.286, p = 0.008) and γ-tocopherol (β = &-*0.229, p = 0.040). We further found negative relationships between serum ferritin and the retinol (β = &-*0.211, p = 0.032) and α-tocopherol levels (β = &-*0.223, p = 0.022) in men over 40 years of age. The present study suggests that the circulatory levels of antioxidant vitamins may modulate the action of insulin and that higher levels of iron might decrease the levels of antioxidant vitamins in the blood.
AB - Retinol, α-tocopherol, and γ-tocopherol are fat-soluble vitamins acting as antioxidants via the prevention of lipid oxidation. Little is known about circulatory levels in healthy individuals. The present cross-sectional study aimed at elucidating the relationship between these antioxidants and clinical biomarkers in 206 male (median age 41 years, range 23-67) employees from companies located in the Okayama Prefecture, Japan. Subjects younger than 40 years (n = 94) showed a positive association of the frequency of alcohol consumption with the circulating retinol (β = 0.344, p = 0.001) and γ-tocopherol levels (β = 0.219, p = 0.041), and an inverse association of fast insulin with serum retinol (β = &-*0.301, p = 0.009). In participants older than 40 years (n = 112) we found that an inverse association of HOMA-R with serum retinol (β = &-*0.262, p = 0.021), α-tocopherol (β = &-*0.236, p = 0.035), and γ-tocopherol levels (β = &-*0.224, p = 0.052); and cigarette smoking was inversely associated with the levels of serum α-tocopherol (β = &-*0.286, p = 0.008) and γ-tocopherol (β = &-*0.229, p = 0.040). We further found negative relationships between serum ferritin and the retinol (β = &-*0.211, p = 0.032) and α-tocopherol levels (β = &-*0.223, p = 0.022) in men over 40 years of age. The present study suggests that the circulatory levels of antioxidant vitamins may modulate the action of insulin and that higher levels of iron might decrease the levels of antioxidant vitamins in the blood.
KW - Alcohol consumption
KW - Homa-r
KW - Serum α-tocopherol
KW - Serum γ-tocopherol
KW - Serum ferritin
KW - Serum retinol
KW - Smoking
UR - http://www.scopus.com/inward/record.url?scp=84893580134&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893580134&partnerID=8YFLogxK
U2 - 10.3390/ijerph110201647
DO - 10.3390/ijerph110201647
M3 - Article
VL - 11
SP - 1647
EP - 1660
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
SN - 1661-7827
IS - 2
ER -