Associations of serum retinol, α-tocopherol, and γ-tocopherol with biomarkers among healthy Japanese men

Yu Zou, Da Hong Wang, Noriko Sakano, Yoshie Sato, Suketaka Iwanaga, Kazuhisa Taketa, Masayuki Kubo, Kei Takemoto, Chie Masatomi, Kiyomi Inoue, Keiki Ogino

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Retinol, α-tocopherol, and γ-tocopherol are fat-soluble vitamins acting as antioxidants via the prevention of lipid oxidation. Little is known about circulatory levels in healthy individuals. The present cross-sectional study aimed at elucidating the relationship between these antioxidants and clinical biomarkers in 206 male (median age 41 years, range 23-67) employees from companies located in the Okayama Prefecture, Japan. Subjects younger than 40 years (n = 94) showed a positive association of the frequency of alcohol consumption with the circulating retinol (β = 0.344, p = 0.001) and γ-tocopherol levels (β = 0.219, p = 0.041), and an inverse association of fast insulin with serum retinol (β = &-*0.301, p = 0.009). In participants older than 40 years (n = 112) we found that an inverse association of HOMA-R with serum retinol (β = &-*0.262, p = 0.021), α-tocopherol (β = &-*0.236, p = 0.035), and γ-tocopherol levels (β = &-*0.224, p = 0.052); and cigarette smoking was inversely associated with the levels of serum α-tocopherol (β = &-*0.286, p = 0.008) and γ-tocopherol (β = &-*0.229, p = 0.040). We further found negative relationships between serum ferritin and the retinol (β = &-*0.211, p = 0.032) and α-tocopherol levels (β = &-*0.223, p = 0.022) in men over 40 years of age. The present study suggests that the circulatory levels of antioxidant vitamins may modulate the action of insulin and that higher levels of iron might decrease the levels of antioxidant vitamins in the blood.

Original languageEnglish
Pages (from-to)1647-1660
Number of pages14
JournalInternational Journal of Environmental Research and Public Health
Volume11
Issue number2
DOIs
Publication statusPublished - Jan 30 2014

Fingerprint

Tocopherols
Vitamin A
Biomarkers
Serum
Antioxidants
Vitamins
Insulin
Ferritins
Alcohol Drinking
Japan
Iron
Cross-Sectional Studies
Smoking
Fats
Lipids

Keywords

  • Alcohol consumption
  • Homa-r
  • Serum α-tocopherol
  • Serum γ-tocopherol
  • Serum ferritin
  • Serum retinol
  • Smoking

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Cite this

Associations of serum retinol, α-tocopherol, and γ-tocopherol with biomarkers among healthy Japanese men. / Zou, Yu; Wang, Da Hong; Sakano, Noriko; Sato, Yoshie; Iwanaga, Suketaka; Taketa, Kazuhisa; Kubo, Masayuki; Takemoto, Kei; Masatomi, Chie; Inoue, Kiyomi; Ogino, Keiki.

In: International Journal of Environmental Research and Public Health, Vol. 11, No. 2, 30.01.2014, p. 1647-1660.

Research output: Contribution to journalArticle

Zou, Y, Wang, DH, Sakano, N, Sato, Y, Iwanaga, S, Taketa, K, Kubo, M, Takemoto, K, Masatomi, C, Inoue, K & Ogino, K 2014, 'Associations of serum retinol, α-tocopherol, and γ-tocopherol with biomarkers among healthy Japanese men', International Journal of Environmental Research and Public Health, vol. 11, no. 2, pp. 1647-1660. https://doi.org/10.3390/ijerph110201647
Zou, Yu ; Wang, Da Hong ; Sakano, Noriko ; Sato, Yoshie ; Iwanaga, Suketaka ; Taketa, Kazuhisa ; Kubo, Masayuki ; Takemoto, Kei ; Masatomi, Chie ; Inoue, Kiyomi ; Ogino, Keiki. / Associations of serum retinol, α-tocopherol, and γ-tocopherol with biomarkers among healthy Japanese men. In: International Journal of Environmental Research and Public Health. 2014 ; Vol. 11, No. 2. pp. 1647-1660.
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