Association study between the fibronectin gene and schizophrenia

Kenji Nakata, Hiroshi Ujike, Ayumu Sakai, Manabu Takaki, Takaki Imamura, Yuji Tanaka, Shigetoshi Kuroda

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Fibronectin is one of the cell adhesion proteins. Adhesion molecules play an important role in neural and synaptic genesis, and their dysfunction may result in neurodevelopmental abnormalities, which have been assumed to be a factor in the pathogenesis of schizophrenia. To examine the possible involvement of fibronectin in the etiology of schizophrenia, we analyzed six polymorphisms, located in introns 2, 21, 24, and 26, and exons 20 and 28, in the human fibronectin gene (FN1) of schizophrenic patients in the Japanese population (n = 104) and age-and gender-matched controls (n = 104). No significant positive association was observed between either of the polymorphisms and schizophrenia, nor was an association found between either of the polymorphisms and any subtypes of schizophrenia. These data did not provide evidence for a contribution of the FN1 gene to susceptibility to schizophrenia.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume116 B
Issue number1
DOIs
Publication statusPublished - Jan 1 2003

Keywords

  • FN1
  • Japanese
  • Polymorphism
  • Schizophrenia

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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