Association study between casein kinase 1 epsilon gene and methamphetamine dependence

T. Kotaka, H. Ujike, Y. Morita, M. Kishimoto, Yuko Okahisa, T. Inada, M. Harano, T. Komiyama, T. Hori, M. Yamada, Y. Sekine, N. Iwata, M. Iyo, I. Sora, N. Ozaki, S. Kuroda

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

Casein kinase 1 epsilon (CKIε) is a component of the DARPP-32 in second-messenger pathway. CKIε phosphorylates and activates DARPP-32, a key molecule in various complex signaling pathways, including dopamine and glutamine signaling, which have both been demonstrated to be main pathways in substance dependence. A recent clinical study showed that rs135745, a noncoding single nucleotide polymorphism of the 3′-untranslated region of the CSNK1E gene, was associated with the intensity of the subjective response to an oral amphetamine dose in normal volunteers. Differences in sensitivity to the drug should affect development of dependence to it. Hence, we genotyped rs135745 of the CSNK1E (MIM 600863) gene in 215 patients with methamphetamine dependence and 274 age- and gender-matched normal controls. No significant differences in genotype and allele frequencies were observed between the patients with methamphetamine dependence and controls. There was also no significant association between rs135745 and the clinical characteristics of methamphetamine dependence and co-morbid methamphetamine psychosis (e.g., age of first consumption, latency of psychosis, prognosis of psychosis after therapy, spontaneous relapse of psychotic symptoms, and poly-substance abuse status). The present findings suggest that having a genetic variant of the CSNK1E gene did not affect susceptibility to methamphetamine dependence or psychosis, at least in a Japanese population.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages43-48
Number of pages6
Volume1139
DOIs
Publication statusPublished - Oct 2008

Publication series

NameAnnals of the New York Academy of Sciences
Volume1139
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Casein Kinase Iepsilon
Methamphetamine
Genes
Psychotic Disorders
Substance-Related Disorders
3' Untranslated Regions
Second Messenger Systems
Amphetamine
Glutamine
Polymorphism
Gene Frequency
Single Nucleotide Polymorphism
Dopamine
Healthy Volunteers
Nucleotides
Genotype
Recurrence
Molecules

Keywords

  • Case-control association study
  • Casein kinase I epsilon gene
  • Clinical phenotype
  • DARPP-32
  • Methamphetamine dependence
  • Methamphetamine psychosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kotaka, T., Ujike, H., Morita, Y., Kishimoto, M., Okahisa, Y., Inada, T., ... Kuroda, S. (2008). Association study between casein kinase 1 epsilon gene and methamphetamine dependence. In Annals of the New York Academy of Sciences (Vol. 1139, pp. 43-48). (Annals of the New York Academy of Sciences; Vol. 1139). https://doi.org/10.1196/annals.1432.025

Association study between casein kinase 1 epsilon gene and methamphetamine dependence. / Kotaka, T.; Ujike, H.; Morita, Y.; Kishimoto, M.; Okahisa, Yuko; Inada, T.; Harano, M.; Komiyama, T.; Hori, T.; Yamada, M.; Sekine, Y.; Iwata, N.; Iyo, M.; Sora, I.; Ozaki, N.; Kuroda, S.

Annals of the New York Academy of Sciences. Vol. 1139 2008. p. 43-48 (Annals of the New York Academy of Sciences; Vol. 1139).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kotaka, T, Ujike, H, Morita, Y, Kishimoto, M, Okahisa, Y, Inada, T, Harano, M, Komiyama, T, Hori, T, Yamada, M, Sekine, Y, Iwata, N, Iyo, M, Sora, I, Ozaki, N & Kuroda, S 2008, Association study between casein kinase 1 epsilon gene and methamphetamine dependence. in Annals of the New York Academy of Sciences. vol. 1139, Annals of the New York Academy of Sciences, vol. 1139, pp. 43-48. https://doi.org/10.1196/annals.1432.025
Kotaka T, Ujike H, Morita Y, Kishimoto M, Okahisa Y, Inada T et al. Association study between casein kinase 1 epsilon gene and methamphetamine dependence. In Annals of the New York Academy of Sciences. Vol. 1139. 2008. p. 43-48. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1432.025
Kotaka, T. ; Ujike, H. ; Morita, Y. ; Kishimoto, M. ; Okahisa, Yuko ; Inada, T. ; Harano, M. ; Komiyama, T. ; Hori, T. ; Yamada, M. ; Sekine, Y. ; Iwata, N. ; Iyo, M. ; Sora, I. ; Ozaki, N. ; Kuroda, S. / Association study between casein kinase 1 epsilon gene and methamphetamine dependence. Annals of the New York Academy of Sciences. Vol. 1139 2008. pp. 43-48 (Annals of the New York Academy of Sciences).
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