TY - JOUR
T1 - Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population
AU - Hotta, Kikuko
AU - Kitamoto, Takuya
AU - Kitamoto, Aya
AU - Mizusawa, Seiho
AU - Matsuo, Tomoaki
AU - Nakata, Yoshio
AU - Kamohara, Seika
AU - Miyatake, Nobuyuki
AU - Kotani, Kazuaki
AU - Komatsu, Ryoya
AU - Itoh, Naoto
AU - Mineo, Ikuo
AU - Wada, Jun
AU - Yoneda, Masato
AU - Nakajima, Atsushi
AU - Funahashi, Tohru
AU - Miyazaki, Shigeru
AU - Tokunaga, Katsuto
AU - Masuzaki, Hiroaki
AU - Ueno, Takato
AU - Hamaguchi, Kazuyuki
AU - Tanaka, Kiyoji
AU - Yamada, Kentaro
AU - Hanafusa, Toshiaki
AU - Oikawa, Shinichi
AU - Yoshimatsu, Hironobu
AU - Sakata, Toshiie
AU - Matsuzawa, Yuji
AU - Nakao, Kazuwa
AU - Sekine, Akihiro
PY - 2011/9
Y1 - 2011/9
N2 - Metabolic syndrome is defined as a cluster of multiple risk factors, including central obesity, dyslipidemia, hypertension and impaired glucose tolerance, that increase cardiovascular disease morbidity and mortality. Genetic factors are important in the development of metabolic syndrome, as are environmental factors. However, the genetic background of metabolic syndrome is not yet fully clarified. There is evidence that obesity and obesity-related phenotypes are associated with variations in several genes, including NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, SH2B1, FTO, MAF, MC4R, KCTD15, SCG3, MTMR9, TFAP2B, MSRA, LYPLAL1, GCKR and FADS1. To investigate the relationship between metabolic syndrome and variations in these genes in the Japanese population, we genotyped 33 single-nucleotide polymorphisms (SNPs) in 19 genes from 1096 patients with metabolic syndrome and 581 control individuals who had no risk factors for metabolic syndrome. Four SNPs in the FTO gene were significantly related to metabolic syndrome: rs9939609 (P=0.00013), rs8050136 (P=0.00011), rs1558902 (P=6.6 × 10 -5) and rs1421085 (P=7.4 × 10 -5). rs3764220 in the SCG3 gene (P=0.0010) and rs2293855 in the MTMR9 gene (P=0.0015) were also significantly associated with metabolic syndrome. SNPs in the FTO, SCG3 and MTMR9 genes had no SNP × SNP epistatic effects on metabolic syndrome. Our data suggest that genetic variations in the FTO, SCG3 and MTMR9 genes independently influence the risk of metabolic syndrome.
AB - Metabolic syndrome is defined as a cluster of multiple risk factors, including central obesity, dyslipidemia, hypertension and impaired glucose tolerance, that increase cardiovascular disease morbidity and mortality. Genetic factors are important in the development of metabolic syndrome, as are environmental factors. However, the genetic background of metabolic syndrome is not yet fully clarified. There is evidence that obesity and obesity-related phenotypes are associated with variations in several genes, including NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, SH2B1, FTO, MAF, MC4R, KCTD15, SCG3, MTMR9, TFAP2B, MSRA, LYPLAL1, GCKR and FADS1. To investigate the relationship between metabolic syndrome and variations in these genes in the Japanese population, we genotyped 33 single-nucleotide polymorphisms (SNPs) in 19 genes from 1096 patients with metabolic syndrome and 581 control individuals who had no risk factors for metabolic syndrome. Four SNPs in the FTO gene were significantly related to metabolic syndrome: rs9939609 (P=0.00013), rs8050136 (P=0.00011), rs1558902 (P=6.6 × 10 -5) and rs1421085 (P=7.4 × 10 -5). rs3764220 in the SCG3 gene (P=0.0010) and rs2293855 in the MTMR9 gene (P=0.0015) were also significantly associated with metabolic syndrome. SNPs in the FTO, SCG3 and MTMR9 genes had no SNP × SNP epistatic effects on metabolic syndrome. Our data suggest that genetic variations in the FTO, SCG3 and MTMR9 genes independently influence the risk of metabolic syndrome.
KW - FTO
KW - MTMR9
KW - SCG3
KW - metabolic syndrome
UR - http://www.scopus.com/inward/record.url?scp=80053261710&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053261710&partnerID=8YFLogxK
U2 - 10.1038/jhg.2011.74
DO - 10.1038/jhg.2011.74
M3 - Article
C2 - 21796137
AN - SCOPUS:80053261710
VL - 56
SP - 647
EP - 651
JO - Jinrui idengaku zasshi. The Japanese journal of human genetics
JF - Jinrui idengaku zasshi. The Japanese journal of human genetics
SN - 1434-5161
IS - 9
ER -
