Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population

Kikuko Hotta; Takuya Kitamoto; Aya Kitamoto; Seiho Mizusawa; Tomoaki Matsuo; Yoshio Nakata; Seika Kamohara; Nobuyuki Miyatake; Kazuaki Kotani; Ryoya Komatsu; Naoto Itoh; Ikuo Mineo; Jun Wada; Masato Yoneda; Atsushi Nakajima; Tohru Funahashi; Shigeru Miyazaki; Katsuto Tokunaga; Hiroaki Masuzaki; Takato Ueno; Kazuyuki Hamaguchi; Kiyoji Tanaka; Kentaro Yamada; Toshiaki Hanafusa; Shinichi Oikawa; Hironobu Yoshimatsu; Toshiie Sakata; Yuji Matsuzawa; Kazuwa Nakao; Akihiro Sekine

doi:10.1038/jhg.2011.74

Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population

Kikuko Hotta, Takuya Kitamoto, Aya Kitamoto, Seiho Mizusawa, Tomoaki Matsuo, Yoshio Nakata, Seika Kamohara, Nobuyuki Miyatake, Kazuaki Kotani, Ryoya Komatsu, Naoto Itoh, Ikuo Mineo, Jun Wada, Masato Yoneda, Atsushi Nakajima, Tohru Funahashi, Shigeru Miyazaki, Katsuto Tokunaga, Hiroaki Masuzaki, Takato UenoKazuyuki Hamaguchi, Kiyoji Tanaka, Kentaro Yamada, Toshiaki Hanafusa, Shinichi Oikawa, Hironobu Yoshimatsu, Toshiie Sakata, Yuji Matsuzawa, Kazuwa Nakao, Akihiro Sekine

Research output: Contribution to journal › Article

49 Citations (Scopus)

Abstract

Metabolic syndrome is defined as a cluster of multiple risk factors, including central obesity, dyslipidemia, hypertension and impaired glucose tolerance, that increase cardiovascular disease morbidity and mortality. Genetic factors are important in the development of metabolic syndrome, as are environmental factors. However, the genetic background of metabolic syndrome is not yet fully clarified. There is evidence that obesity and obesity-related phenotypes are associated with variations in several genes, including NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, SH2B1, FTO, MAF, MC4R, KCTD15, SCG3, MTMR9, TFAP2B, MSRA, LYPLAL1, GCKR and FADS1. To investigate the relationship between metabolic syndrome and variations in these genes in the Japanese population, we genotyped 33 single-nucleotide polymorphisms (SNPs) in 19 genes from 1096 patients with metabolic syndrome and 581 control individuals who had no risk factors for metabolic syndrome. Four SNPs in the FTO gene were significantly related to metabolic syndrome: rs9939609 (P=0.00013), rs8050136 (P=0.00011), rs1558902 (P=6.6 × 10 ^-5) and rs1421085 (P=7.4 × 10 ^-5). rs3764220 in the SCG3 gene (P=0.0010) and rs2293855 in the MTMR9 gene (P=0.0015) were also significantly associated with metabolic syndrome. SNPs in the FTO, SCG3 and MTMR9 genes had no SNP × SNP epistatic effects on metabolic syndrome. Our data suggest that genetic variations in the FTO, SCG3 and MTMR9 genes independently influence the risk of metabolic syndrome.

Original language	English
Pages (from-to)	647-651
Number of pages	5
Journal	Journal of Human Genetics
Volume	56
Issue number	9
DOIs	https://doi.org/10.1038/jhg.2011.74
Publication status	Published - Sep 2011

Keywords

FTO
MTMR9
SCG3
metabolic syndrome

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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Hotta, K., Kitamoto, T., Kitamoto, A., Mizusawa, S., Matsuo, T., Nakata, Y., Kamohara, S., Miyatake, N., Kotani, K., Komatsu, R., Itoh, N., Mineo, I., Wada, J., Yoneda, M., Nakajima, A., Funahashi, T., Miyazaki, S., Tokunaga, K., Masuzaki, H., ... Sekine, A. (2011). Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population. Journal of Human Genetics, 56(9), 647-651. https://doi.org/10.1038/jhg.2011.74

Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population. / Hotta, Kikuko; Kitamoto, Takuya; Kitamoto, Aya; Mizusawa, Seiho; Matsuo, Tomoaki; Nakata, Yoshio; Kamohara, Seika; Miyatake, Nobuyuki; Kotani, Kazuaki; Komatsu, Ryoya; Itoh, Naoto; Mineo, Ikuo; Wada, Jun; Yoneda, Masato; Nakajima, Atsushi; Funahashi, Tohru; Miyazaki, Shigeru; Tokunaga, Katsuto; Masuzaki, Hiroaki; Ueno, Takato; Hamaguchi, Kazuyuki; Tanaka, Kiyoji; Yamada, Kentaro; Hanafusa, Toshiaki; Oikawa, Shinichi; Yoshimatsu, Hironobu; Sakata, Toshiie; Matsuzawa, Yuji; Nakao, Kazuwa; Sekine, Akihiro.

In: Journal of Human Genetics, Vol. 56, No. 9, 09.2011, p. 647-651.

Research output: Contribution to journal › Article

Hotta, K, Kitamoto, T, Kitamoto, A, Mizusawa, S, Matsuo, T, Nakata, Y, Kamohara, S, Miyatake, N, Kotani, K, Komatsu, R, Itoh, N, Mineo, I, Wada, J, Yoneda, M, Nakajima, A, Funahashi, T, Miyazaki, S, Tokunaga, K, Masuzaki, H, Ueno, T, Hamaguchi, K, Tanaka, K, Yamada, K, Hanafusa, T, Oikawa, S, Yoshimatsu, H, Sakata, T, Matsuzawa, Y, Nakao, K & Sekine, A 2011, 'Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population', Journal of Human Genetics, vol. 56, no. 9, pp. 647-651. https://doi.org/10.1038/jhg.2011.74

Hotta, Kikuko ; Kitamoto, Takuya ; Kitamoto, Aya ; Mizusawa, Seiho ; Matsuo, Tomoaki ; Nakata, Yoshio ; Kamohara, Seika ; Miyatake, Nobuyuki ; Kotani, Kazuaki ; Komatsu, Ryoya ; Itoh, Naoto ; Mineo, Ikuo ; Wada, Jun ; Yoneda, Masato ; Nakajima, Atsushi ; Funahashi, Tohru ; Miyazaki, Shigeru ; Tokunaga, Katsuto ; Masuzaki, Hiroaki ; Ueno, Takato ; Hamaguchi, Kazuyuki ; Tanaka, Kiyoji ; Yamada, Kentaro ; Hanafusa, Toshiaki ; Oikawa, Shinichi ; Yoshimatsu, Hironobu ; Sakata, Toshiie ; Matsuzawa, Yuji ; Nakao, Kazuwa ; Sekine, Akihiro. / Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population. In: Journal of Human Genetics. 2011 ; Vol. 56, No. 9. pp. 647-651.

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abstract = "Metabolic syndrome is defined as a cluster of multiple risk factors, including central obesity, dyslipidemia, hypertension and impaired glucose tolerance, that increase cardiovascular disease morbidity and mortality. Genetic factors are important in the development of metabolic syndrome, as are environmental factors. However, the genetic background of metabolic syndrome is not yet fully clarified. There is evidence that obesity and obesity-related phenotypes are associated with variations in several genes, including NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, SH2B1, FTO, MAF, MC4R, KCTD15, SCG3, MTMR9, TFAP2B, MSRA, LYPLAL1, GCKR and FADS1. To investigate the relationship between metabolic syndrome and variations in these genes in the Japanese population, we genotyped 33 single-nucleotide polymorphisms (SNPs) in 19 genes from 1096 patients with metabolic syndrome and 581 control individuals who had no risk factors for metabolic syndrome. Four SNPs in the FTO gene were significantly related to metabolic syndrome: rs9939609 (P=0.00013), rs8050136 (P=0.00011), rs1558902 (P=6.6 × 10 -5) and rs1421085 (P=7.4 × 10 -5). rs3764220 in the SCG3 gene (P=0.0010) and rs2293855 in the MTMR9 gene (P=0.0015) were also significantly associated with metabolic syndrome. SNPs in the FTO, SCG3 and MTMR9 genes had no SNP × SNP epistatic effects on metabolic syndrome. Our data suggest that genetic variations in the FTO, SCG3 and MTMR9 genes independently influence the risk of metabolic syndrome.",

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AU - Hotta, Kikuko

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AU - Mizusawa, Seiho

AU - Matsuo, Tomoaki

AU - Nakata, Yoshio

AU - Kamohara, Seika

AU - Miyatake, Nobuyuki

AU - Kotani, Kazuaki

AU - Komatsu, Ryoya

AU - Itoh, Naoto

AU - Mineo, Ikuo

AU - Wada, Jun

AU - Yoneda, Masato

AU - Nakajima, Atsushi

AU - Funahashi, Tohru

AU - Miyazaki, Shigeru

AU - Tokunaga, Katsuto

AU - Masuzaki, Hiroaki

AU - Ueno, Takato

AU - Hamaguchi, Kazuyuki

AU - Tanaka, Kiyoji

AU - Yamada, Kentaro

AU - Hanafusa, Toshiaki

AU - Oikawa, Shinichi

AU - Yoshimatsu, Hironobu

AU - Sakata, Toshiie

AU - Matsuzawa, Yuji

AU - Nakao, Kazuwa

AU - Sekine, Akihiro

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N2 - Metabolic syndrome is defined as a cluster of multiple risk factors, including central obesity, dyslipidemia, hypertension and impaired glucose tolerance, that increase cardiovascular disease morbidity and mortality. Genetic factors are important in the development of metabolic syndrome, as are environmental factors. However, the genetic background of metabolic syndrome is not yet fully clarified. There is evidence that obesity and obesity-related phenotypes are associated with variations in several genes, including NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, SH2B1, FTO, MAF, MC4R, KCTD15, SCG3, MTMR9, TFAP2B, MSRA, LYPLAL1, GCKR and FADS1. To investigate the relationship between metabolic syndrome and variations in these genes in the Japanese population, we genotyped 33 single-nucleotide polymorphisms (SNPs) in 19 genes from 1096 patients with metabolic syndrome and 581 control individuals who had no risk factors for metabolic syndrome. Four SNPs in the FTO gene were significantly related to metabolic syndrome: rs9939609 (P=0.00013), rs8050136 (P=0.00011), rs1558902 (P=6.6 × 10 -5) and rs1421085 (P=7.4 × 10 -5). rs3764220 in the SCG3 gene (P=0.0010) and rs2293855 in the MTMR9 gene (P=0.0015) were also significantly associated with metabolic syndrome. SNPs in the FTO, SCG3 and MTMR9 genes had no SNP × SNP epistatic effects on metabolic syndrome. Our data suggest that genetic variations in the FTO, SCG3 and MTMR9 genes independently influence the risk of metabolic syndrome.

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