Association of the metastatic phenotype with CCN family members among breast and oral cancer cells

Toshihiro Ohgawara, Satoshi Kubota, Harumi Kawaki, Naito Kurio, Tarek Abd El Kader, Mitsuhiro Hoshijima, Danilo Janune, Tsuyoshi Shimo, Bernard Perbal, Akira Sasaki, Masaharu Takigawa

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


The CCN family of proteins consists of six members with conserved structural features. These proteins play several roles in the physiology and pathology of cells. Among the pathological roles of the CCN family, one of the most important and controversial ones is their role in the expansion and metastasis of cancer. Up to now a number of reports have described the possible role of each CCN family member independently. In this study, we comprehensively analyzed the roles of all six CCN family members in cell growth, migration and invasion of breast cancer cells in vitro and in vivo. As a result, we found the CCN2/CCN3 ratio to be a parameter that is associated with the metastatic phenotype of breast cancer cells that are highly metastatic to the bone. The same analysis with cell lines from oral squamous carcinomas that are not metastatic to the bone further supported our notion. These results suggest the functional significance of the interplay between CCN family members in regulating the phenotype of cancer cells.

Original languageEnglish
Pages (from-to)291-299
Number of pages9
JournalJournal of Cell Communication and Signaling
Issue number4
Publication statusPublished - Dec 2011


  • Bone metastasis
  • Breast cancer
  • CCN family
  • CCN2
  • CCN3
  • Oral cancer

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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