TY - JOUR
T1 - Association of the benefit from gefitinib monotherapy with smoking status in Japanese patients with non-small-cell lung cancer
AU - Hotta, Katsuyuki
AU - Kiura, Katsuyuki
AU - Takigawa, Nagio
AU - Fujiwara, Yoshiro
AU - Tabata, Masahiro
AU - Ueoka, Hiroshi
AU - Tanimoto, Mitsune
PY - 2008/11
Y1 - 2008/11
N2 - Background: Gefitinib has been reported to be more effective in patients with non-small-cell lung cancer (NSCLC) who had low or never-smoking history than for heavier smokers. However, this has been criticized because the better survival in such subpopulation might be attributable simply to their favorable natural history, rather than any treatment effect. Methods: We retrospectively reviewed the clinical records of 155 Japanese patients with relapsed NSCLC who received gefitinib (gefitinib-treated patients; n = 83) and those who did not receive it, but were treated with other cytotoxic agents (gefitinib-untreated patients; n = 72). A light smoker was defined as one with <20 pack-years. Survival was assessed stratified by gefitinib treatment and smoking status using stepwise proportional hazard modeling. Results: Among the 155 relapsed patients, 58 (37%) had low or never-smoking history. The benefit from gefitinib monotherapy was associated with smoking status (test for interaction, p = 0.01). Gefitinib monotherapy, as compared to the cytotoxic agents, significantly prolonged survival among patients with low or never-smoking history (hazard ratio [HR] = 0.377; 95% confidence interval [CI] = 0.181-0.785; p = 0.01), but not among the heavier smokers. Additionally, among gefitinib-treated patients, those with low or never-smoking history survived longer than heavier smokers (HR = 0.461; 95% CI = 0.244-0.871; p = 0.02), while the survival benefit of cytotoxic agents was comparable between those with low or never-smoking history and with heavy smoking habits among the gefitinib-untreated group. Conclusions: Patients with relapsed NSCLC and low or never-smoking habits appeared to benefit from gefitinib monotherapy, while patients with heavy smoking habits did not.
AB - Background: Gefitinib has been reported to be more effective in patients with non-small-cell lung cancer (NSCLC) who had low or never-smoking history than for heavier smokers. However, this has been criticized because the better survival in such subpopulation might be attributable simply to their favorable natural history, rather than any treatment effect. Methods: We retrospectively reviewed the clinical records of 155 Japanese patients with relapsed NSCLC who received gefitinib (gefitinib-treated patients; n = 83) and those who did not receive it, but were treated with other cytotoxic agents (gefitinib-untreated patients; n = 72). A light smoker was defined as one with <20 pack-years. Survival was assessed stratified by gefitinib treatment and smoking status using stepwise proportional hazard modeling. Results: Among the 155 relapsed patients, 58 (37%) had low or never-smoking history. The benefit from gefitinib monotherapy was associated with smoking status (test for interaction, p = 0.01). Gefitinib monotherapy, as compared to the cytotoxic agents, significantly prolonged survival among patients with low or never-smoking history (hazard ratio [HR] = 0.377; 95% confidence interval [CI] = 0.181-0.785; p = 0.01), but not among the heavier smokers. Additionally, among gefitinib-treated patients, those with low or never-smoking history survived longer than heavier smokers (HR = 0.461; 95% CI = 0.244-0.871; p = 0.02), while the survival benefit of cytotoxic agents was comparable between those with low or never-smoking history and with heavy smoking habits among the gefitinib-untreated group. Conclusions: Patients with relapsed NSCLC and low or never-smoking habits appeared to benefit from gefitinib monotherapy, while patients with heavy smoking habits did not.
KW - Cytotoxic agent
KW - Gefitinib
KW - Non-small-cell lung cancer
KW - Smoking status
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U2 - 10.1016/j.lungcan.2008.03.025
DO - 10.1016/j.lungcan.2008.03.025
M3 - Article
C2 - 18485523
AN - SCOPUS:53949121226
VL - 62
SP - 236
EP - 241
JO - Lung Cancer
JF - Lung Cancer
SN - 0169-5002
IS - 2
ER -