Association of serum arginase i with oxidative stress in a healthy population

Keiki Ogino, Noriko Takahashi, Tomoko Takigawa, Yasushi Obase, Da Hong Wang

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The association of serum arginase I with oxidative stress was evaluated cross-sectionally in a healthy population. The mean levels of serum arginase I in healthy people (n 278) were 32.6 ± 22.3 ng/ml. Significant correlations of arginase I were observed with age, WBC, RBC, alanine aminotransferase (ALT), high-sensitivity C-reactive protein (hs-CRP), uric acid, body mass index (BMI) and urinary 8-isoprostane. Multiple regression analysis showed significant associations of arginase I with WBC, RBC, urinary 8-hydroxydeoxyguanosine (8-OHdG), age, HbA1c and urinary 8-isoprostane. In the associations of arginase I with 8-OHdG, 8-isoprostane and HbA1c, confounding factors and lifestyle factors such as sex, old age, smoking and alcohol consumption were involved. It was concluded that serum arginase I was associated with oxidative stress and HbA1c in addition to age, WBC and RBC in healthy Japanese people and may become a new biomarker for early prediction of diabetes mellitus and other oxidative stress-related diseases

Original languageEnglish
Pages (from-to)147-155
Number of pages9
JournalFree Radical Research
Volume45
Issue number2
DOIs
Publication statusPublished - Feb 2011

Fingerprint

Arginase
8-epi-prostaglandin F2alpha
Oxidative stress
Oxidative Stress
Serum
Population
Biomarkers
Medical problems
Uric Acid
Alanine Transaminase
Regression analysis
Alcohol Drinking
C-Reactive Protein
Life Style
Diabetes Mellitus
Body Mass Index
Smoking
Regression Analysis
Alcohols
Association reactions

Keywords

  • Arginase I
  • Healthy people
  • Oxidative stress
  • Population study

ASJC Scopus subject areas

  • Biochemistry

Cite this

Association of serum arginase i with oxidative stress in a healthy population. / Ogino, Keiki; Takahashi, Noriko; Takigawa, Tomoko; Obase, Yasushi; Wang, Da Hong.

In: Free Radical Research, Vol. 45, No. 2, 02.2011, p. 147-155.

Research output: Contribution to journalArticle

Ogino, K, Takahashi, N, Takigawa, T, Obase, Y & Wang, DH 2011, 'Association of serum arginase i with oxidative stress in a healthy population', Free Radical Research, vol. 45, no. 2, pp. 147-155. https://doi.org/10.3109/10715762.2010.520318
Ogino, Keiki ; Takahashi, Noriko ; Takigawa, Tomoko ; Obase, Yasushi ; Wang, Da Hong. / Association of serum arginase i with oxidative stress in a healthy population. In: Free Radical Research. 2011 ; Vol. 45, No. 2. pp. 147-155.
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