TY - JOUR
T1 - Association of salivary lactate dehydrogenase level with systemic inflammation in a Japanese population
AU - Miyoshi, N.
AU - Tanigawa, T.
AU - Nishioka, S.
AU - Maruyama, K.
AU - Eguchi, E.
AU - Tanaka, K.
AU - Saito, I.
AU - Yamazaki, K.
AU - Miyake, Y.
N1 - Funding Information:
We thank all the participants and support staff of the Toon Health Study. We also thank the municipal authorities and their employees, officers and health professionals in Toon city for their substantial contribution. This study was partly supported by grants-in-aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (grants-in-aid for Research B, no. 22390134 from 2010 to 2012 and 25293142 from 2013 to 2015, and grant-in-aid for Young Scientists B, no 25860443 and 25860441 from 2013 to 2015), Health and Labor Sciences Research Grants from the Ministry of Health, Welfare, and Labor, Japan (Comprehensive Research on Life-Style Related Diseases including Cardiovascular Diseases and Diabetes Mellitus, no 201021038A from 2010 to 2012), and 8020 Promotion Foundation, Japan in 2012.
Funding Information:
Grants-in-Aid for Scientific Research from The Ministry of Education, Culture, Sports, Science and Technology of Japan, Grant/ Award Number: Research B/22390134, Research B/25293142, Young Scientists B/25860441 and Young Scientists B/25860443; 8020 Promotion Foundation; Health and Labor Sciences Research Grants from the Ministry of Health, Welfare, and Labor, Grant/Award Number: 201021038A
PY - 2018/8
Y1 - 2018/8
N2 - Background and Objective: Salivary lactate dehydrogenase (LDH) was reported to be a useful parameter for the screening of periodontal disease. We performed a cross-sectional study to verify the usefulness of salivary LDH as a biomarker of periodontitis and to investigate the association of severity of periodontitis with systemic inflammation by measuring salivary LDH and serum high sensitive C-reactive protein (hs-CRP) levels in a community-based middle-aged and elderly population in Japan. Material and Methods: We recruited 644 men and 1171 women, aged 30-79 years, who participated in the Toon Health Study during 2011–15. Periodontal condition was assessed by full-mouth examination including mean value of probing depth, percentage of probing depth of ≥4 mm and ≥6 mm, and bleeding on probing. Saliva and blood serum samples were collected for measurement of salivary LDH level and hs-CRP, respectively. A linear trend across quartiles of salivary LDH was calculated using linear regression. Interaction of salivary LDH and overweight status (body mass index of ≥25 kg/m2) was tested using the cross-product term of log-transformed continuous salivary LDH and overweight status. Results: Analysis of covariance adjusted for potential confounders revealed strong associations between salivary LDH level and the indicators of periodontal condition (P <.01) in both men and women. Sex- and age-adjusted mean values of hs-CRP according to salivary LDH quartiles were 0.40, 0.45, 0.45 and 0.50 mg/L (P for trend <.01). Although the association was attenuated after further adjustment for body mass index, hypertension, diabetes mellitus, dyslipidemia, alcohol intake, smoking status and physical activity. When stratified by overweight status, the association remained significant in overweight individuals (P =.03). The multivariable adjusted odds ratio of hs-CRP level of ≥1 mg/L for the highest vs lowest quartile of salivary LDH was 1.93 (95% CI, 1.01-3.69) in overweight individuals, but not significant in non-overweight individuals. Conclusion: Salivary LDH appears to be a promising biomarker for the mass screening of periodontitis in local community health settings. High salivary LDH levels, particularly in overweight individuals might contribute to prevention of cardiovascular disease, through measuring systemic inflammatory burdens as well as traditional cardiovascular risk factors.
AB - Background and Objective: Salivary lactate dehydrogenase (LDH) was reported to be a useful parameter for the screening of periodontal disease. We performed a cross-sectional study to verify the usefulness of salivary LDH as a biomarker of periodontitis and to investigate the association of severity of periodontitis with systemic inflammation by measuring salivary LDH and serum high sensitive C-reactive protein (hs-CRP) levels in a community-based middle-aged and elderly population in Japan. Material and Methods: We recruited 644 men and 1171 women, aged 30-79 years, who participated in the Toon Health Study during 2011–15. Periodontal condition was assessed by full-mouth examination including mean value of probing depth, percentage of probing depth of ≥4 mm and ≥6 mm, and bleeding on probing. Saliva and blood serum samples were collected for measurement of salivary LDH level and hs-CRP, respectively. A linear trend across quartiles of salivary LDH was calculated using linear regression. Interaction of salivary LDH and overweight status (body mass index of ≥25 kg/m2) was tested using the cross-product term of log-transformed continuous salivary LDH and overweight status. Results: Analysis of covariance adjusted for potential confounders revealed strong associations between salivary LDH level and the indicators of periodontal condition (P <.01) in both men and women. Sex- and age-adjusted mean values of hs-CRP according to salivary LDH quartiles were 0.40, 0.45, 0.45 and 0.50 mg/L (P for trend <.01). Although the association was attenuated after further adjustment for body mass index, hypertension, diabetes mellitus, dyslipidemia, alcohol intake, smoking status and physical activity. When stratified by overweight status, the association remained significant in overweight individuals (P =.03). The multivariable adjusted odds ratio of hs-CRP level of ≥1 mg/L for the highest vs lowest quartile of salivary LDH was 1.93 (95% CI, 1.01-3.69) in overweight individuals, but not significant in non-overweight individuals. Conclusion: Salivary LDH appears to be a promising biomarker for the mass screening of periodontitis in local community health settings. High salivary LDH levels, particularly in overweight individuals might contribute to prevention of cardiovascular disease, through measuring systemic inflammatory burdens as well as traditional cardiovascular risk factors.
KW - biomarkers
KW - cardiovascular disease
KW - epidemiology
KW - oral hygiene
KW - periodontitis
KW - salivary diagnostics
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U2 - 10.1111/jre.12537
DO - 10.1111/jre.12537
M3 - Article
C2 - 29446092
AN - SCOPUS:85042138190
VL - 53
SP - 487
EP - 494
JO - Journal of Periodontal Research
JF - Journal of Periodontal Research
SN - 0022-3484
IS - 4
ER -