Association of new arterial stiffness parameter, the cardio-ankle vascular index, with left ventricular diastolic function

Kosuke Sakane, Toru Miyoshi, Masayuki Doi, Satoshi Hirohata, Youko Kaji, Shigeshi Kamikawa, Hiroko Ogawa, Kunihiko Hatanaka, Tomoki Kitawaki, Shozo Kusachi, Kazuhide Yamamoto

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


Aim: Pulse wave velocity has been used as an index of aortic stiffness. Recently, the cardio-ankle vascular index (CAVI), which reflects the stiffness of the aorta independently of blood pressure, has been developed. In this study, we analyzed the relationship between CAVI and left ventricular (LV) diastolic dysfunction. Methods: A total of 119 patients were referred for echocardiography to evaluate ventricular function. Patients with reduced systolic function were excluded. Patients were divided on the basis of normal or reduced LV diastolic function determined by echocardiography. CAVI was measured using an automatic waveform analyzer. Results: CAVI was significantly higher in patients with reduced LV diastolic function than those with normal LV diastolic function (9.0 ± 1.1 and 8.5 ± 1. 1, p= 0.009). Multiple linear regression analysis revealed that CAVI was independently associated with the ratio of peak early diastolic velocity to peak atrial diastolic velocity an left atrial diameter. When patients were classified on the basis of CAVI quartiles, multiple logistic regression analysis demonstrated that the highest quartile of CAVI showed an increased odds ratio for the presence of IV diastolic dysfunction. Conclusion: The present study revealed that an increased CAVI was independently associated with LV diastolic dysfunction in patient's with preserved systolic function.

Original languageEnglish
Pages (from-to)261-268
Number of pages8
JournalJournal of atherosclerosis and thrombosis
Issue number5
Publication statusPublished - 2008


  • Arterial stiffness
  • Cardio-ankle vascular index
  • Left ventricular diastolic dysfunction
  • Pulse wave velocity

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical


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