Association of new arterial stiffness parameter, the cardio-ankle vascular index, with left ventricular diastolic function

Kosuke Sakane, Toru Miyoshi, Masayuki Doi, Satoshi Hirohata, Youko Kaji, Shigeshi Kamikawa, Hiroko Ogawa, Kunihiko Hatanaka, Tomoki Kitawaki, Shozo Kusachi, Kazuhide Yamamoto

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Aim: Pulse wave velocity has been used as an index of aortic stiffness. Recently, the cardio-ankle vascular index (CAVI), which reflects the stiffness of the aorta independently of blood pressure, has been developed. In this study, we analyzed the relationship between CAVI and left ventricular (LV) diastolic dysfunction. Methods: A total of 119 patients were referred for echocardiography to evaluate ventricular function. Patients with reduced systolic function were excluded. Patients were divided on the basis of normal or reduced LV diastolic function determined by echocardiography. CAVI was measured using an automatic waveform analyzer. Results: CAVI was significantly higher in patients with reduced LV diastolic function than those with normal LV diastolic function (9.0 ± 1.1 and 8.5 ± 1. 1, p= 0.009). Multiple linear regression analysis revealed that CAVI was independently associated with the ratio of peak early diastolic velocity to peak atrial diastolic velocity an left atrial diameter. When patients were classified on the basis of CAVI quartiles, multiple logistic regression analysis demonstrated that the highest quartile of CAVI showed an increased odds ratio for the presence of IV diastolic dysfunction. Conclusion: The present study revealed that an increased CAVI was independently associated with LV diastolic dysfunction in patient's with preserved systolic function.

Original languageEnglish
Pages (from-to)261-268
Number of pages8
JournalJournal of Atherosclerosis and Thrombosis
Volume15
Issue number5
Publication statusPublished - 2008

Fingerprint

Vascular Stiffness
Left Ventricular Function
Ankle
Blood Vessels
Stiffness
Echocardiography
Regression analysis
Left Ventricular Dysfunction
Blood pressure
Regression Analysis
Linear regression
Pulse Wave Analysis
Ventricular Function
Logistics
Aorta
Linear Models
Logistic Models
Odds Ratio
Blood Pressure

Keywords

  • Arterial stiffness
  • Cardio-ankle vascular index
  • Left ventricular diastolic dysfunction
  • Pulse wave velocity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Biochemistry, medical

Cite this

Association of new arterial stiffness parameter, the cardio-ankle vascular index, with left ventricular diastolic function. / Sakane, Kosuke; Miyoshi, Toru; Doi, Masayuki; Hirohata, Satoshi; Kaji, Youko; Kamikawa, Shigeshi; Ogawa, Hiroko; Hatanaka, Kunihiko; Kitawaki, Tomoki; Kusachi, Shozo; Yamamoto, Kazuhide.

In: Journal of Atherosclerosis and Thrombosis, Vol. 15, No. 5, 2008, p. 261-268.

Research output: Contribution to journalArticle

Sakane, K, Miyoshi, T, Doi, M, Hirohata, S, Kaji, Y, Kamikawa, S, Ogawa, H, Hatanaka, K, Kitawaki, T, Kusachi, S & Yamamoto, K 2008, 'Association of new arterial stiffness parameter, the cardio-ankle vascular index, with left ventricular diastolic function', Journal of Atherosclerosis and Thrombosis, vol. 15, no. 5, pp. 261-268.
Sakane, Kosuke ; Miyoshi, Toru ; Doi, Masayuki ; Hirohata, Satoshi ; Kaji, Youko ; Kamikawa, Shigeshi ; Ogawa, Hiroko ; Hatanaka, Kunihiko ; Kitawaki, Tomoki ; Kusachi, Shozo ; Yamamoto, Kazuhide. / Association of new arterial stiffness parameter, the cardio-ankle vascular index, with left ventricular diastolic function. In: Journal of Atherosclerosis and Thrombosis. 2008 ; Vol. 15, No. 5. pp. 261-268.
@article{f8d4c0780ece444ea4c9099286ea3426,
title = "Association of new arterial stiffness parameter, the cardio-ankle vascular index, with left ventricular diastolic function",
abstract = "Aim: Pulse wave velocity has been used as an index of aortic stiffness. Recently, the cardio-ankle vascular index (CAVI), which reflects the stiffness of the aorta independently of blood pressure, has been developed. In this study, we analyzed the relationship between CAVI and left ventricular (LV) diastolic dysfunction. Methods: A total of 119 patients were referred for echocardiography to evaluate ventricular function. Patients with reduced systolic function were excluded. Patients were divided on the basis of normal or reduced LV diastolic function determined by echocardiography. CAVI was measured using an automatic waveform analyzer. Results: CAVI was significantly higher in patients with reduced LV diastolic function than those with normal LV diastolic function (9.0 ± 1.1 and 8.5 ± 1. 1, p= 0.009). Multiple linear regression analysis revealed that CAVI was independently associated with the ratio of peak early diastolic velocity to peak atrial diastolic velocity an left atrial diameter. When patients were classified on the basis of CAVI quartiles, multiple logistic regression analysis demonstrated that the highest quartile of CAVI showed an increased odds ratio for the presence of IV diastolic dysfunction. Conclusion: The present study revealed that an increased CAVI was independently associated with LV diastolic dysfunction in patient's with preserved systolic function.",
keywords = "Arterial stiffness, Cardio-ankle vascular index, Left ventricular diastolic dysfunction, Pulse wave velocity",
author = "Kosuke Sakane and Toru Miyoshi and Masayuki Doi and Satoshi Hirohata and Youko Kaji and Shigeshi Kamikawa and Hiroko Ogawa and Kunihiko Hatanaka and Tomoki Kitawaki and Shozo Kusachi and Kazuhide Yamamoto",
year = "2008",
language = "English",
volume = "15",
pages = "261--268",
journal = "Journal of Atherosclerosis and Thrombosis",
issn = "1340-3478",
publisher = "Japan Atherosclerosis Society",
number = "5",

}

TY - JOUR

T1 - Association of new arterial stiffness parameter, the cardio-ankle vascular index, with left ventricular diastolic function

AU - Sakane, Kosuke

AU - Miyoshi, Toru

AU - Doi, Masayuki

AU - Hirohata, Satoshi

AU - Kaji, Youko

AU - Kamikawa, Shigeshi

AU - Ogawa, Hiroko

AU - Hatanaka, Kunihiko

AU - Kitawaki, Tomoki

AU - Kusachi, Shozo

AU - Yamamoto, Kazuhide

PY - 2008

Y1 - 2008

N2 - Aim: Pulse wave velocity has been used as an index of aortic stiffness. Recently, the cardio-ankle vascular index (CAVI), which reflects the stiffness of the aorta independently of blood pressure, has been developed. In this study, we analyzed the relationship between CAVI and left ventricular (LV) diastolic dysfunction. Methods: A total of 119 patients were referred for echocardiography to evaluate ventricular function. Patients with reduced systolic function were excluded. Patients were divided on the basis of normal or reduced LV diastolic function determined by echocardiography. CAVI was measured using an automatic waveform analyzer. Results: CAVI was significantly higher in patients with reduced LV diastolic function than those with normal LV diastolic function (9.0 ± 1.1 and 8.5 ± 1. 1, p= 0.009). Multiple linear regression analysis revealed that CAVI was independently associated with the ratio of peak early diastolic velocity to peak atrial diastolic velocity an left atrial diameter. When patients were classified on the basis of CAVI quartiles, multiple logistic regression analysis demonstrated that the highest quartile of CAVI showed an increased odds ratio for the presence of IV diastolic dysfunction. Conclusion: The present study revealed that an increased CAVI was independently associated with LV diastolic dysfunction in patient's with preserved systolic function.

AB - Aim: Pulse wave velocity has been used as an index of aortic stiffness. Recently, the cardio-ankle vascular index (CAVI), which reflects the stiffness of the aorta independently of blood pressure, has been developed. In this study, we analyzed the relationship between CAVI and left ventricular (LV) diastolic dysfunction. Methods: A total of 119 patients were referred for echocardiography to evaluate ventricular function. Patients with reduced systolic function were excluded. Patients were divided on the basis of normal or reduced LV diastolic function determined by echocardiography. CAVI was measured using an automatic waveform analyzer. Results: CAVI was significantly higher in patients with reduced LV diastolic function than those with normal LV diastolic function (9.0 ± 1.1 and 8.5 ± 1. 1, p= 0.009). Multiple linear regression analysis revealed that CAVI was independently associated with the ratio of peak early diastolic velocity to peak atrial diastolic velocity an left atrial diameter. When patients were classified on the basis of CAVI quartiles, multiple logistic regression analysis demonstrated that the highest quartile of CAVI showed an increased odds ratio for the presence of IV diastolic dysfunction. Conclusion: The present study revealed that an increased CAVI was independently associated with LV diastolic dysfunction in patient's with preserved systolic function.

KW - Arterial stiffness

KW - Cardio-ankle vascular index

KW - Left ventricular diastolic dysfunction

KW - Pulse wave velocity

UR - http://www.scopus.com/inward/record.url?scp=56349154471&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56349154471&partnerID=8YFLogxK

M3 - Article

C2 - 18981651

AN - SCOPUS:56349154471

VL - 15

SP - 261

EP - 268

JO - Journal of Atherosclerosis and Thrombosis

JF - Journal of Atherosclerosis and Thrombosis

SN - 1340-3478

IS - 5

ER -