Association of IRF5 polymorphism with MPO-ANCA-positive vasculitis in a Japanese population

A. Kawasaki, N. Inoue, C. Ajimi, Kenei Sada, S. Kobayashi, H. Yamada, H. Furukawa, T. Sumida, S. Tohma, N. Miyasaka, S. Matsuo, S. Ozaki, H. Hashimoto, Hirofumi Makino, M. Harigai, N. Tsuchiya

Research output: Contribution to journalArticle

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Abstract

Interferon regulatory factor 5 (IRF5) and signal transducer and activator of transcription 4 (STAT4) are shared susceptibility genes for various autoimmune diseases. In this study, we investigated whether these genes also contribute to susceptibility to anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a Japanese population. A case-control study was carried out on IRF5 rs10954213 and STAT4 rs7574865 in 232 Japanese myeloperoxidase (MPO)-ANCA-positive AAV patients, including 177 microscopic polyangiitis and 710 healthy controls. IRF5 rs10954213G was significantly increased in MPO-ANCA-positive AAV (additive model, P=0.023, odds ratio=1.27, 95% confidence interval=1.03-1.57). The risk allele was previously shown to be associated with lower mRNA level of IRF5. On the other hand, significant association of STAT4 rs7574865T with AAV was not detected. These observations suggested that IRF5 may contribute to susceptibility to MPO-ANCA-positive AAV in a Japanese population.

Original languageEnglish
Pages (from-to)527-529
Number of pages3
JournalGenes and Immunity
Volume14
Issue number8
DOIs
Publication statusPublished - Dec 2013

Fingerprint

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Interferon Regulatory Factors
Antineutrophil Cytoplasmic Antibodies
Vasculitis
STAT4 Transcription Factor
Peroxidase
Population
Microscopic Polyangiitis
Genes
Autoimmune Diseases
Case-Control Studies
Alleles
Odds Ratio
Confidence Intervals
Messenger RNA

Keywords

  • ANCA-associated vasculitis
  • IRF5
  • myeloperoxidase
  • polymorphism

ASJC Scopus subject areas

  • Genetics(clinical)
  • Immunology
  • Genetics

Cite this

Kawasaki, A., Inoue, N., Ajimi, C., Sada, K., Kobayashi, S., Yamada, H., ... Tsuchiya, N. (2013). Association of IRF5 polymorphism with MPO-ANCA-positive vasculitis in a Japanese population. Genes and Immunity, 14(8), 527-529. https://doi.org/10.1038/gene.2013.45

Association of IRF5 polymorphism with MPO-ANCA-positive vasculitis in a Japanese population. / Kawasaki, A.; Inoue, N.; Ajimi, C.; Sada, Kenei; Kobayashi, S.; Yamada, H.; Furukawa, H.; Sumida, T.; Tohma, S.; Miyasaka, N.; Matsuo, S.; Ozaki, S.; Hashimoto, H.; Makino, Hirofumi; Harigai, M.; Tsuchiya, N.

In: Genes and Immunity, Vol. 14, No. 8, 12.2013, p. 527-529.

Research output: Contribution to journalArticle

Kawasaki, A, Inoue, N, Ajimi, C, Sada, K, Kobayashi, S, Yamada, H, Furukawa, H, Sumida, T, Tohma, S, Miyasaka, N, Matsuo, S, Ozaki, S, Hashimoto, H, Makino, H, Harigai, M & Tsuchiya, N 2013, 'Association of IRF5 polymorphism with MPO-ANCA-positive vasculitis in a Japanese population', Genes and Immunity, vol. 14, no. 8, pp. 527-529. https://doi.org/10.1038/gene.2013.45
Kawasaki, A. ; Inoue, N. ; Ajimi, C. ; Sada, Kenei ; Kobayashi, S. ; Yamada, H. ; Furukawa, H. ; Sumida, T. ; Tohma, S. ; Miyasaka, N. ; Matsuo, S. ; Ozaki, S. ; Hashimoto, H. ; Makino, Hirofumi ; Harigai, M. ; Tsuchiya, N. / Association of IRF5 polymorphism with MPO-ANCA-positive vasculitis in a Japanese population. In: Genes and Immunity. 2013 ; Vol. 14, No. 8. pp. 527-529.
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abstract = "Interferon regulatory factor 5 (IRF5) and signal transducer and activator of transcription 4 (STAT4) are shared susceptibility genes for various autoimmune diseases. In this study, we investigated whether these genes also contribute to susceptibility to anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a Japanese population. A case-control study was carried out on IRF5 rs10954213 and STAT4 rs7574865 in 232 Japanese myeloperoxidase (MPO)-ANCA-positive AAV patients, including 177 microscopic polyangiitis and 710 healthy controls. IRF5 rs10954213G was significantly increased in MPO-ANCA-positive AAV (additive model, P=0.023, odds ratio=1.27, 95{\%} confidence interval=1.03-1.57). The risk allele was previously shown to be associated with lower mRNA level of IRF5. On the other hand, significant association of STAT4 rs7574865T with AAV was not detected. These observations suggested that IRF5 may contribute to susceptibility to MPO-ANCA-positive AAV in a Japanese population.",
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AU - Kobayashi, S.

AU - Yamada, H.

AU - Furukawa, H.

AU - Sumida, T.

AU - Tohma, S.

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AU - Matsuo, S.

AU - Ozaki, S.

AU - Hashimoto, H.

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AU - Tsuchiya, N.

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