Association of increased plasma adipocyte fatty acid-binding protein with coronary artery disease in non-elderly men

Masayuki Doi, Toru Miyoshi, Satoshi Hirohata, Kazufumi Nakamura, Shinichi Usui, Ko Takeda, Mutsumi Iwamoto, Shozo Kusachi, Kengo Kusano, Hiroshi Itoh

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Abstract

Adipocyte fatty acid-binding protein (A-FABP) has been reported to play critical roles in the development of atherosclerosis. We investigated whether an increased in plasma A-FABP level can be independently associated with the presence of coronary artery disease (CAD).Methods: Two hundred eleven consecutive male patients (mean age: 66 years, range: 33-87 years) were enrolled from inpatients who underwent coronary angiography. Age-matched male subjects (n = 211) having no evidence of CAD served as controls. Plasma A-FABP levels were measured by enzyme-linked immunosorbent assays.Results: Plasma A-FABP levels in CAD patients were significantly higher than in control subjects (median [IQR], 20.6 [15.7-27.8] ng/mL vs. 15.1 [11.7-19.9] ng/mL, p <0.01). Multivariate logistic regression analysis revealed that an increased plasma A-FABP level was independently associated with the presence of CAD in all subjects (adjusted odds ratio: 1.76, 95% confidence interval: 1.14 to 2.70, p = 0.01). Furthermore, sub-analysis based on age showed that this association remained significant in subjects aged <65 years (adjusted odds ratio: 3.06, 95% confidence interval: 1.34 to 6.98, p <0.01), but not in subjects aged ≥65 years.Conclusions: Increased plasma A-FABP in non-elderly men had a significant association with the presence of CAD, independent of established CAD risk factors.

Original languageEnglish
Article number44
JournalCardiovascular Diabetology
Volume10
DOIs
Publication statusPublished - May 23 2011

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Fatty Acid-Binding Proteins
Adipocytes
Coronary Artery Disease
Odds Ratio
Confidence Intervals
Coronary Angiography
Inpatients
Atherosclerosis
Logistic Models
Enzyme-Linked Immunosorbent Assay
Regression Analysis

Keywords

  • Adipocyte
  • Coronary artery disease
  • Fatty acid-binding protein
  • Risk factor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Association of increased plasma adipocyte fatty acid-binding protein with coronary artery disease in non-elderly men. / Doi, Masayuki; Miyoshi, Toru; Hirohata, Satoshi; Nakamura, Kazufumi; Usui, Shinichi; Takeda, Ko; Iwamoto, Mutsumi; Kusachi, Shozo; Kusano, Kengo; Itoh, Hiroshi.

In: Cardiovascular Diabetology, Vol. 10, 44, 23.05.2011.

Research output: Contribution to journalArticle

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AU - Takeda, Ko

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AB - Adipocyte fatty acid-binding protein (A-FABP) has been reported to play critical roles in the development of atherosclerosis. We investigated whether an increased in plasma A-FABP level can be independently associated with the presence of coronary artery disease (CAD).Methods: Two hundred eleven consecutive male patients (mean age: 66 years, range: 33-87 years) were enrolled from inpatients who underwent coronary angiography. Age-matched male subjects (n = 211) having no evidence of CAD served as controls. Plasma A-FABP levels were measured by enzyme-linked immunosorbent assays.Results: Plasma A-FABP levels in CAD patients were significantly higher than in control subjects (median [IQR], 20.6 [15.7-27.8] ng/mL vs. 15.1 [11.7-19.9] ng/mL, p <0.01). Multivariate logistic regression analysis revealed that an increased plasma A-FABP level was independently associated with the presence of CAD in all subjects (adjusted odds ratio: 1.76, 95% confidence interval: 1.14 to 2.70, p = 0.01). Furthermore, sub-analysis based on age showed that this association remained significant in subjects aged <65 years (adjusted odds ratio: 3.06, 95% confidence interval: 1.34 to 6.98, p <0.01), but not in subjects aged ≥65 years.Conclusions: Increased plasma A-FABP in non-elderly men had a significant association with the presence of CAD, independent of established CAD risk factors.

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