Association of HNPCC and endometrial cancers

Kouji Banno, Nobuyuld Susumu, Megumi Yanokura, Takeshi Hirao, Takashi Iwata, Akira Hirasawa, Daisuke Aoki, Kokichi Sugano, Shiro Nozawa

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Hereditary nonpolyposis colorectal cancer (HNPCC) is among the representative familial cancers that are autosomally dominant inherited disorders. Because endometrial cancers develop at high rates in women with HNPCC, it is suggested that some endometrial cancers are familial cancers that are induced by mutations of the DNA mismatch repair (MMR) genes, as in HNPCC. To understand the clinical pathology of familial endometrial cancers that are associated with HNPCC, we surveyed the family histories of 385 patients with endometrial cancer and found that 0.5% of endometrial cancers met the new diagnostic criteria of HNPCC. From molecular and biological analyses, we found microsatellite instability in 30.8% of endometrial cancers and germline mutations of MMR genes in 8.3%. These results suggest a close relationship of MMR gene mutations to the development of endometrial cancers. For a better understanding of the clinical pathology of HNPCC-associated familial endometrial cancers, it is critical for gynecologists to perform a large multicenter study, including detailed family histories.

Original languageEnglish
Pages (from-to)262-269
Number of pages8
JournalInternational Journal of Clinical Oncology
Volume9
Issue number4
DOIs
Publication statusPublished - Aug 1 2004
Externally publishedYes

Fingerprint

Hereditary Nonpolyposis Colorectal Neoplasms
Endometrial Neoplasms
DNA Mismatch Repair
Clinical Pathology
Genes
Microsatellite Instability
Mutation
Germ-Line Mutation
Multicenter Studies
Neoplasms

Keywords

  • Endometrial cancer
  • hMLH1
  • hMSH2
  • HNPCC
  • Revised Amsterdam Criteria

ASJC Scopus subject areas

  • Surgery
  • Hematology
  • Oncology

Cite this

Banno, K., Susumu, N., Yanokura, M., Hirao, T., Iwata, T., Hirasawa, A., ... Nozawa, S. (2004). Association of HNPCC and endometrial cancers. International Journal of Clinical Oncology, 9(4), 262-269. https://doi.org/10.1007/s10147-004-0402-8

Association of HNPCC and endometrial cancers. / Banno, Kouji; Susumu, Nobuyuld; Yanokura, Megumi; Hirao, Takeshi; Iwata, Takashi; Hirasawa, Akira; Aoki, Daisuke; Sugano, Kokichi; Nozawa, Shiro.

In: International Journal of Clinical Oncology, Vol. 9, No. 4, 01.08.2004, p. 262-269.

Research output: Contribution to journalReview article

Banno, K, Susumu, N, Yanokura, M, Hirao, T, Iwata, T, Hirasawa, A, Aoki, D, Sugano, K & Nozawa, S 2004, 'Association of HNPCC and endometrial cancers', International Journal of Clinical Oncology, vol. 9, no. 4, pp. 262-269. https://doi.org/10.1007/s10147-004-0402-8
Banno, Kouji ; Susumu, Nobuyuld ; Yanokura, Megumi ; Hirao, Takeshi ; Iwata, Takashi ; Hirasawa, Akira ; Aoki, Daisuke ; Sugano, Kokichi ; Nozawa, Shiro. / Association of HNPCC and endometrial cancers. In: International Journal of Clinical Oncology. 2004 ; Vol. 9, No. 4. pp. 262-269.
@article{8efe9c0f1bb44c52824527bc2336cc81,
title = "Association of HNPCC and endometrial cancers",
abstract = "Hereditary nonpolyposis colorectal cancer (HNPCC) is among the representative familial cancers that are autosomally dominant inherited disorders. Because endometrial cancers develop at high rates in women with HNPCC, it is suggested that some endometrial cancers are familial cancers that are induced by mutations of the DNA mismatch repair (MMR) genes, as in HNPCC. To understand the clinical pathology of familial endometrial cancers that are associated with HNPCC, we surveyed the family histories of 385 patients with endometrial cancer and found that 0.5{\%} of endometrial cancers met the new diagnostic criteria of HNPCC. From molecular and biological analyses, we found microsatellite instability in 30.8{\%} of endometrial cancers and germline mutations of MMR genes in 8.3{\%}. These results suggest a close relationship of MMR gene mutations to the development of endometrial cancers. For a better understanding of the clinical pathology of HNPCC-associated familial endometrial cancers, it is critical for gynecologists to perform a large multicenter study, including detailed family histories.",
keywords = "Endometrial cancer, hMLH1, hMSH2, HNPCC, Revised Amsterdam Criteria",
author = "Kouji Banno and Nobuyuld Susumu and Megumi Yanokura and Takeshi Hirao and Takashi Iwata and Akira Hirasawa and Daisuke Aoki and Kokichi Sugano and Shiro Nozawa",
year = "2004",
month = "8",
day = "1",
doi = "10.1007/s10147-004-0402-8",
language = "English",
volume = "9",
pages = "262--269",
journal = "International Journal of Clinical Oncology",
issn = "1341-9625",
publisher = "Springer Japan",
number = "4",

}

TY - JOUR

T1 - Association of HNPCC and endometrial cancers

AU - Banno, Kouji

AU - Susumu, Nobuyuld

AU - Yanokura, Megumi

AU - Hirao, Takeshi

AU - Iwata, Takashi

AU - Hirasawa, Akira

AU - Aoki, Daisuke

AU - Sugano, Kokichi

AU - Nozawa, Shiro

PY - 2004/8/1

Y1 - 2004/8/1

N2 - Hereditary nonpolyposis colorectal cancer (HNPCC) is among the representative familial cancers that are autosomally dominant inherited disorders. Because endometrial cancers develop at high rates in women with HNPCC, it is suggested that some endometrial cancers are familial cancers that are induced by mutations of the DNA mismatch repair (MMR) genes, as in HNPCC. To understand the clinical pathology of familial endometrial cancers that are associated with HNPCC, we surveyed the family histories of 385 patients with endometrial cancer and found that 0.5% of endometrial cancers met the new diagnostic criteria of HNPCC. From molecular and biological analyses, we found microsatellite instability in 30.8% of endometrial cancers and germline mutations of MMR genes in 8.3%. These results suggest a close relationship of MMR gene mutations to the development of endometrial cancers. For a better understanding of the clinical pathology of HNPCC-associated familial endometrial cancers, it is critical for gynecologists to perform a large multicenter study, including detailed family histories.

AB - Hereditary nonpolyposis colorectal cancer (HNPCC) is among the representative familial cancers that are autosomally dominant inherited disorders. Because endometrial cancers develop at high rates in women with HNPCC, it is suggested that some endometrial cancers are familial cancers that are induced by mutations of the DNA mismatch repair (MMR) genes, as in HNPCC. To understand the clinical pathology of familial endometrial cancers that are associated with HNPCC, we surveyed the family histories of 385 patients with endometrial cancer and found that 0.5% of endometrial cancers met the new diagnostic criteria of HNPCC. From molecular and biological analyses, we found microsatellite instability in 30.8% of endometrial cancers and germline mutations of MMR genes in 8.3%. These results suggest a close relationship of MMR gene mutations to the development of endometrial cancers. For a better understanding of the clinical pathology of HNPCC-associated familial endometrial cancers, it is critical for gynecologists to perform a large multicenter study, including detailed family histories.

KW - Endometrial cancer

KW - hMLH1

KW - hMSH2

KW - HNPCC

KW - Revised Amsterdam Criteria

UR - http://www.scopus.com/inward/record.url?scp=4644262947&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4644262947&partnerID=8YFLogxK

U2 - 10.1007/s10147-004-0402-8

DO - 10.1007/s10147-004-0402-8

M3 - Review article

C2 - 15375702

AN - SCOPUS:4644262947

VL - 9

SP - 262

EP - 269

JO - International Journal of Clinical Oncology

JF - International Journal of Clinical Oncology

SN - 1341-9625

IS - 4

ER -