Association of HLA antigen and restriction fragment length polymorphism of T cell receptor β-chain gene with Graves' disease and Hashimoto's thyroiditis

M. Ito, M. Tanimoto, H. Kamura, M. Yoneda, Y. Morishima, K. Yamauchi, T. Itatsu, K. Takatsuki, H. Saito

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

HLA antigen phenotypes and BglII restriction fragment length polymorphism of T cell receptor β-chain (TCRβ) gene were analyzed in 61 patients with Graves' disease and 50 patients with Hashimoto's thyroiditis. The antigen frequency of HLA-Bw46 in both Graves' disease (23.0%) and Hashimoto's thyroiditis (24.0%) was significantly higher than that in normal population (8.0%), with relative risks (RR) of 3.45 [corrected P (Pc)

Original languageEnglish
Pages (from-to)100-104
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume69
Issue number1
Publication statusPublished - 1989
Externally publishedYes

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T-Cell Receptor Genes
Hashimoto Disease
Graves Disease
HLA Antigens
T-Cell Antigen Receptor
Polymorphism
Restriction Fragment Length Polymorphisms
Genes
Phenotype
Antigens
Population
HLA-B46 antigen

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Association of HLA antigen and restriction fragment length polymorphism of T cell receptor β-chain gene with Graves' disease and Hashimoto's thyroiditis. / Ito, M.; Tanimoto, M.; Kamura, H.; Yoneda, M.; Morishima, Y.; Yamauchi, K.; Itatsu, T.; Takatsuki, K.; Saito, H.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 69, No. 1, 1989, p. 100-104.

Research output: Contribution to journalArticle

Ito, M, Tanimoto, M, Kamura, H, Yoneda, M, Morishima, Y, Yamauchi, K, Itatsu, T, Takatsuki, K & Saito, H 1989, 'Association of HLA antigen and restriction fragment length polymorphism of T cell receptor β-chain gene with Graves' disease and Hashimoto's thyroiditis', Journal of Clinical Endocrinology and Metabolism, vol. 69, no. 1, pp. 100-104.
Ito, M. ; Tanimoto, M. ; Kamura, H. ; Yoneda, M. ; Morishima, Y. ; Yamauchi, K. ; Itatsu, T. ; Takatsuki, K. ; Saito, H. / Association of HLA antigen and restriction fragment length polymorphism of T cell receptor β-chain gene with Graves' disease and Hashimoto's thyroiditis. In: Journal of Clinical Endocrinology and Metabolism. 1989 ; Vol. 69, No. 1. pp. 100-104.
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AU - Takatsuki, K.

AU - Saito, H.

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