Association of hepatic oxidative stress and iron dysregulation with HCC development after interferon therapy in chronic hepatitis C

Shintaro Nanba, Fusao Ikeda, Nobuyuki Baba, Koichi Takaguchi, Tomonori Senoh, Takuya Nagano, Hiroyuki Seki, Yasuto Takeuchi, Yuki Moritou, Tetsuya Yasunaka, Hideki Ohnishi, Yasuhiro Miyake, Akinobu Takaki, Kazuhiro Nouso, Yoshiaki Iwasaki, Kazuhide Yamamoto

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background Oxidative stress may play pathogenic roles in the mechanisms underlying chronic hepatitis C (CHC). The impact of excessive oxidative stress and iron dysregulation on the development of hepatocellular carcinoma (HCC) after interferon therapy has not been established. Methods We investigated the impact of oxidative stress and iron deposition on HCC development after therapy with pegylated interferon (PegIFN)+ribavirin in CHC patients. Systemic and intracellular iron homeostasis was evaluated in liver tissues, peripheral blood mononuclear cells and sera. Results Of 203 patients enrolled, 13 developed HCC during the 5.6-year follow-up. High hepatic 8-hydroxy-2-deoxyguanosine (8-OHdG) levels were significantly associated with HCC development in multivariate analysis (p=0.0012) which was also significantly correlated with severity of hepatic iron deposition before therapy (p

Original languageEnglish
Pages (from-to)226-233
Number of pages8
JournalJournal of Clinical Pathology
Volume69
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

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Chronic Hepatitis C
Interferons
Hepatocellular Carcinoma
Oxidative Stress
Iron
Liver
Ribavirin
Therapeutics
Blood Cells
Homeostasis
Multivariate Analysis
Serum

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Association of hepatic oxidative stress and iron dysregulation with HCC development after interferon therapy in chronic hepatitis C. / Nanba, Shintaro; Ikeda, Fusao; Baba, Nobuyuki; Takaguchi, Koichi; Senoh, Tomonori; Nagano, Takuya; Seki, Hiroyuki; Takeuchi, Yasuto; Moritou, Yuki; Yasunaka, Tetsuya; Ohnishi, Hideki; Miyake, Yasuhiro; Takaki, Akinobu; Nouso, Kazuhiro; Iwasaki, Yoshiaki; Yamamoto, Kazuhide.

In: Journal of Clinical Pathology, Vol. 69, No. 3, 01.03.2016, p. 226-233.

Research output: Contribution to journalArticle

Nanba, S, Ikeda, F, Baba, N, Takaguchi, K, Senoh, T, Nagano, T, Seki, H, Takeuchi, Y, Moritou, Y, Yasunaka, T, Ohnishi, H, Miyake, Y, Takaki, A, Nouso, K, Iwasaki, Y & Yamamoto, K 2016, 'Association of hepatic oxidative stress and iron dysregulation with HCC development after interferon therapy in chronic hepatitis C', Journal of Clinical Pathology, vol. 69, no. 3, pp. 226-233. https://doi.org/10.1136/jclinpath-2015-203215
Nanba, Shintaro ; Ikeda, Fusao ; Baba, Nobuyuki ; Takaguchi, Koichi ; Senoh, Tomonori ; Nagano, Takuya ; Seki, Hiroyuki ; Takeuchi, Yasuto ; Moritou, Yuki ; Yasunaka, Tetsuya ; Ohnishi, Hideki ; Miyake, Yasuhiro ; Takaki, Akinobu ; Nouso, Kazuhiro ; Iwasaki, Yoshiaki ; Yamamoto, Kazuhide. / Association of hepatic oxidative stress and iron dysregulation with HCC development after interferon therapy in chronic hepatitis C. In: Journal of Clinical Pathology. 2016 ; Vol. 69, No. 3. pp. 226-233.
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