Association of Helicobacter pylori with gastroduodenal diseases

Yoshikazu Hirai, Shunji Hayashi, Hirofumi Shimomura, Keiji Oguma, Kenji Yokota

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Helicobacter pylori was first cultured in vitro in 1982. This bacterium is a spiral gram-negative rod which grows under microaerophilic conditions. The ecological niche is the mucosa of the human stomach which had been thought to be aseptic before the discovery of this bacterium. This organism causes a long-lasting infection throughout a person's life if there is no medical intervention. Numerous persons are infected with the organism around the world, and the rate of infection in Japan is nearly 50 of the population. However, the route of infection remains unclear because the organism has not been isolated from any environment other than several animals. H. pylori is now recognized as a causative agent of gastritis and peptic ulcers. Though gastritis, and especially chronic active gastritis, is observed at least histologically in all persons with H. pylori, peptic ulcers develop in only some infected persons. Specific factors in the host and/or the bacteria are needed for the development of peptic ulcer disease. Furthermore, H. pylori is considered to be related to the development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma, especially those of low grade. Also, H. pylori infection is a major determinant for initiating the sequence of events leading to gastric cancer. In some patients with low-grade gastric MALT lymphoma, the eradication of H. pylori led to a regression of lesion. Gastric cancer has been induced in Mongolian gerbils with long-term H. pylori infection. The combinations of drugs, which consist of an antisecretory agent (acid-supressing agent) and antimicrobial agents, are used for the eradication of the organism. Eradication therapy is recommended at least for patients with peptic ulcers.

Original languageEnglish
Pages (from-to)183-197
Number of pages15
JournalJapanese Journal of Infectious Diseases
Volume52
Issue number5
Publication statusPublished - Oct 1999

Fingerprint

Helicobacter pylori
Peptic Ulcer
Gastritis
Marginal Zone B-Cell Lymphoma
Helicobacter Infections
Gastric Mucosa
Bacteria
Stomach Neoplasms
Infection
Gerbillinae
Drug Combinations
Anti-Infective Agents
Stomach
Japan
Mucous Membrane
Acids
Population

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Association of Helicobacter pylori with gastroduodenal diseases. / Hirai, Yoshikazu; Hayashi, Shunji; Shimomura, Hirofumi; Oguma, Keiji; Yokota, Kenji.

In: Japanese Journal of Infectious Diseases, Vol. 52, No. 5, 10.1999, p. 183-197.

Research output: Contribution to journalArticle

Hirai, Y, Hayashi, S, Shimomura, H, Oguma, K & Yokota, K 1999, 'Association of Helicobacter pylori with gastroduodenal diseases', Japanese Journal of Infectious Diseases, vol. 52, no. 5, pp. 183-197.
Hirai, Yoshikazu ; Hayashi, Shunji ; Shimomura, Hirofumi ; Oguma, Keiji ; Yokota, Kenji. / Association of Helicobacter pylori with gastroduodenal diseases. In: Japanese Journal of Infectious Diseases. 1999 ; Vol. 52, No. 5. pp. 183-197.
@article{7031b39208b94aac8332a5a9373fc109,
title = "Association of Helicobacter pylori with gastroduodenal diseases",
abstract = "Helicobacter pylori was first cultured in vitro in 1982. This bacterium is a spiral gram-negative rod which grows under microaerophilic conditions. The ecological niche is the mucosa of the human stomach which had been thought to be aseptic before the discovery of this bacterium. This organism causes a long-lasting infection throughout a person's life if there is no medical intervention. Numerous persons are infected with the organism around the world, and the rate of infection in Japan is nearly 50 of the population. However, the route of infection remains unclear because the organism has not been isolated from any environment other than several animals. H. pylori is now recognized as a causative agent of gastritis and peptic ulcers. Though gastritis, and especially chronic active gastritis, is observed at least histologically in all persons with H. pylori, peptic ulcers develop in only some infected persons. Specific factors in the host and/or the bacteria are needed for the development of peptic ulcer disease. Furthermore, H. pylori is considered to be related to the development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma, especially those of low grade. Also, H. pylori infection is a major determinant for initiating the sequence of events leading to gastric cancer. In some patients with low-grade gastric MALT lymphoma, the eradication of H. pylori led to a regression of lesion. Gastric cancer has been induced in Mongolian gerbils with long-term H. pylori infection. The combinations of drugs, which consist of an antisecretory agent (acid-supressing agent) and antimicrobial agents, are used for the eradication of the organism. Eradication therapy is recommended at least for patients with peptic ulcers.",
author = "Yoshikazu Hirai and Shunji Hayashi and Hirofumi Shimomura and Keiji Oguma and Kenji Yokota",
year = "1999",
month = "10",
language = "English",
volume = "52",
pages = "183--197",
journal = "Japanese Journal of Infectious Diseases",
issn = "1344-6304",
publisher = "National Institute of Health",
number = "5",

}

TY - JOUR

T1 - Association of Helicobacter pylori with gastroduodenal diseases

AU - Hirai, Yoshikazu

AU - Hayashi, Shunji

AU - Shimomura, Hirofumi

AU - Oguma, Keiji

AU - Yokota, Kenji

PY - 1999/10

Y1 - 1999/10

N2 - Helicobacter pylori was first cultured in vitro in 1982. This bacterium is a spiral gram-negative rod which grows under microaerophilic conditions. The ecological niche is the mucosa of the human stomach which had been thought to be aseptic before the discovery of this bacterium. This organism causes a long-lasting infection throughout a person's life if there is no medical intervention. Numerous persons are infected with the organism around the world, and the rate of infection in Japan is nearly 50 of the population. However, the route of infection remains unclear because the organism has not been isolated from any environment other than several animals. H. pylori is now recognized as a causative agent of gastritis and peptic ulcers. Though gastritis, and especially chronic active gastritis, is observed at least histologically in all persons with H. pylori, peptic ulcers develop in only some infected persons. Specific factors in the host and/or the bacteria are needed for the development of peptic ulcer disease. Furthermore, H. pylori is considered to be related to the development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma, especially those of low grade. Also, H. pylori infection is a major determinant for initiating the sequence of events leading to gastric cancer. In some patients with low-grade gastric MALT lymphoma, the eradication of H. pylori led to a regression of lesion. Gastric cancer has been induced in Mongolian gerbils with long-term H. pylori infection. The combinations of drugs, which consist of an antisecretory agent (acid-supressing agent) and antimicrobial agents, are used for the eradication of the organism. Eradication therapy is recommended at least for patients with peptic ulcers.

AB - Helicobacter pylori was first cultured in vitro in 1982. This bacterium is a spiral gram-negative rod which grows under microaerophilic conditions. The ecological niche is the mucosa of the human stomach which had been thought to be aseptic before the discovery of this bacterium. This organism causes a long-lasting infection throughout a person's life if there is no medical intervention. Numerous persons are infected with the organism around the world, and the rate of infection in Japan is nearly 50 of the population. However, the route of infection remains unclear because the organism has not been isolated from any environment other than several animals. H. pylori is now recognized as a causative agent of gastritis and peptic ulcers. Though gastritis, and especially chronic active gastritis, is observed at least histologically in all persons with H. pylori, peptic ulcers develop in only some infected persons. Specific factors in the host and/or the bacteria are needed for the development of peptic ulcer disease. Furthermore, H. pylori is considered to be related to the development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma, especially those of low grade. Also, H. pylori infection is a major determinant for initiating the sequence of events leading to gastric cancer. In some patients with low-grade gastric MALT lymphoma, the eradication of H. pylori led to a regression of lesion. Gastric cancer has been induced in Mongolian gerbils with long-term H. pylori infection. The combinations of drugs, which consist of an antisecretory agent (acid-supressing agent) and antimicrobial agents, are used for the eradication of the organism. Eradication therapy is recommended at least for patients with peptic ulcers.

UR - http://www.scopus.com/inward/record.url?scp=0033399533&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033399533&partnerID=8YFLogxK

M3 - Article

VL - 52

SP - 183

EP - 197

JO - Japanese Journal of Infectious Diseases

JF - Japanese Journal of Infectious Diseases

SN - 1344-6304

IS - 5

ER -