Abstract
The Na+/Ca2+ exchanger (NCX) is a membrane protein involved in calcium homeostasis, catalyzing the exchange of one Ca2+ ion for three Na+ ions across the cell membrane. The Na+/Ca2+ exchange has been suggested to play a role in the pathogenesis of hypertension. Therefore, we examined whether genetic variations in NCX1 were associated with hypertension. Among 15 polymorphisms identified in 96 hypertensive subjects by sequencing the entire exon and promoter regions of NCX1, 7 representative polymorphisms with a minor allele frequency of greater than 4% were genotyped in 1,865 individuals, of whom 787 were hypertensive and 1,072 were normotensive. These subjects were residents of Suita City and were randomly selected as a population for the Suita cohort study. Multivariate logistic regression analysis performed after adjusting for age, body mass index, hyperlipidemia, diabetes mellitus, smoking, and drinking revealed that the -23200T>C and -23181T>C polymorphisms in the 5′ upstream region of exon 1c were significantly associated with hypertension in men (-23200T>C: CC vs. TC+TT: odds ratio=0.61; 95% confidence intervals: 0.39 to 0.97; p=0.04) and in women (-23181T>C: CC vs. TC+TT: odds ratio=1.45; 95% confidence intervals: 1.04 to 2.02; p=0.03), respectively. Thus, our study suggests that NCX1 is one of the genes related to susceptibility to essential hypertension in the Japanese general population.
| Original language | English |
|---|---|
| Pages (from-to) | 697-702 |
| Number of pages | 6 |
| Journal | Hypertension Research |
| Volume | 27 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2004 |
| Externally published | Yes |
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Keywords
- Gene variants
- Hypertension
- Na/Ca exchanger
- NCX1
ASJC Scopus subject areas
- Internal Medicine
Cite this
Association of genetic polymorphisms of sodium-calcium exchanger 1 gene, NCX1, with hypertension in a Japanese general population. / Kokubo, Yoshihiro; Inamoto, Nozomu; Tomoike, Hitonobu; Kamide, Kei; Takiuchi, Shin; Kawano, Yuhei; Tanaka, Chihiro; Katanosaka, Yuki; Wakabayashi, Shigeo; Shigekawa, Munekazu; Hishikawa, Otosaburo; Miyata, Toshiyuki.
In: Hypertension Research, Vol. 27, No. 10, 10.2004, p. 697-702.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of genetic polymorphisms of sodium-calcium exchanger 1 gene, NCX1, with hypertension in a Japanese general population
AU - Kokubo, Yoshihiro
AU - Inamoto, Nozomu
AU - Tomoike, Hitonobu
AU - Kamide, Kei
AU - Takiuchi, Shin
AU - Kawano, Yuhei
AU - Tanaka, Chihiro
AU - Katanosaka, Yuki
AU - Wakabayashi, Shigeo
AU - Shigekawa, Munekazu
AU - Hishikawa, Otosaburo
AU - Miyata, Toshiyuki
PY - 2004/10
Y1 - 2004/10
N2 - The Na+/Ca2+ exchanger (NCX) is a membrane protein involved in calcium homeostasis, catalyzing the exchange of one Ca2+ ion for three Na+ ions across the cell membrane. The Na+/Ca2+ exchange has been suggested to play a role in the pathogenesis of hypertension. Therefore, we examined whether genetic variations in NCX1 were associated with hypertension. Among 15 polymorphisms identified in 96 hypertensive subjects by sequencing the entire exon and promoter regions of NCX1, 7 representative polymorphisms with a minor allele frequency of greater than 4% were genotyped in 1,865 individuals, of whom 787 were hypertensive and 1,072 were normotensive. These subjects were residents of Suita City and were randomly selected as a population for the Suita cohort study. Multivariate logistic regression analysis performed after adjusting for age, body mass index, hyperlipidemia, diabetes mellitus, smoking, and drinking revealed that the -23200T>C and -23181T>C polymorphisms in the 5′ upstream region of exon 1c were significantly associated with hypertension in men (-23200T>C: CC vs. TC+TT: odds ratio=0.61; 95% confidence intervals: 0.39 to 0.97; p=0.04) and in women (-23181T>C: CC vs. TC+TT: odds ratio=1.45; 95% confidence intervals: 1.04 to 2.02; p=0.03), respectively. Thus, our study suggests that NCX1 is one of the genes related to susceptibility to essential hypertension in the Japanese general population.
AB - The Na+/Ca2+ exchanger (NCX) is a membrane protein involved in calcium homeostasis, catalyzing the exchange of one Ca2+ ion for three Na+ ions across the cell membrane. The Na+/Ca2+ exchange has been suggested to play a role in the pathogenesis of hypertension. Therefore, we examined whether genetic variations in NCX1 were associated with hypertension. Among 15 polymorphisms identified in 96 hypertensive subjects by sequencing the entire exon and promoter regions of NCX1, 7 representative polymorphisms with a minor allele frequency of greater than 4% were genotyped in 1,865 individuals, of whom 787 were hypertensive and 1,072 were normotensive. These subjects were residents of Suita City and were randomly selected as a population for the Suita cohort study. Multivariate logistic regression analysis performed after adjusting for age, body mass index, hyperlipidemia, diabetes mellitus, smoking, and drinking revealed that the -23200T>C and -23181T>C polymorphisms in the 5′ upstream region of exon 1c were significantly associated with hypertension in men (-23200T>C: CC vs. TC+TT: odds ratio=0.61; 95% confidence intervals: 0.39 to 0.97; p=0.04) and in women (-23181T>C: CC vs. TC+TT: odds ratio=1.45; 95% confidence intervals: 1.04 to 2.02; p=0.03), respectively. Thus, our study suggests that NCX1 is one of the genes related to susceptibility to essential hypertension in the Japanese general population.
KW - Gene variants
KW - Hypertension
KW - Na/Ca exchanger
KW - NCX1
UR - http://www.scopus.com/inward/record.url?scp=19944368379&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=19944368379&partnerID=8YFLogxK
U2 - 10.1291/hypres.27.697
DO - 10.1291/hypres.27.697
M3 - Article
C2 - 15785003
AN - SCOPUS:19944368379
VL - 27
SP - 697
EP - 702
JO - Hypertension Research
JF - Hypertension Research
SN - 0916-9636
IS - 10
ER -