Association of Fatty Liver with Increased Ratio of Visceral to Subcutaneous Adipose Tissue in Obese Men

Sabina Mahmood, Kazuhisa Taketa, Kaori Imai, Yasumasa Kajihara, Shigeki Imai, Tsuneo Yokobayashi, Shinichiro Yamamoto, Mikio Sato, Hiroyuki Omori, Koji Manabe

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Abstract

We studied the association of fatty liver with subcutaneous and visceral obesity in 46 male and 36 female patients with body mass index (BMI) over 22kg/m2. The correlation coefficient between the ratio of the visceral adipose tissue to the subcutaneous adipose tissue (V/S) and the computed tomography (CT) number of the liver was - 0.299 (P<0.05) and that between the V/S ratio and the ratio of the CT number of the liver to that of the spleen (CT-L/CT-S) was - 0.335 (P<0.05) in the males. Partial correlation analysis after making correction for BMI showed an increased correlation coefficient of - 0.485 (P<0.05) between the V/S ratio and the CT-L/CT-S ratio in the males. The odds ratio in the males for CT-L/CT-S below 1.0 and V/S above 1.0 was 3.25 with a 95 % confidence interval of 1.02 to 9.39. No such association between the V/S ratio and the CT-L/CT-S ratio was present in the female patients. Multiple regression analysis with serum level of alanine aminotransferase, a marker of fatty liver, as an independent variable revealed a partial regression coefficient of - 17.7 for CT-L/CT-S (P<0.05) in the males and - 21.7 (P<0.05) in the females, validating the CT-L/CT-S ratio as an index of fatty liver. The results indicate the association of fatty liver as determined by the CT-L/CT-S ratio with visceral obesity in males.

Original languageEnglish
Pages (from-to)225-231
Number of pages7
JournalActa medica Okayama
Volume52
Issue number4
Publication statusPublished - Aug 1 1998

Keywords

  • Computed tomography number
  • Fatty liver
  • Visceral obesity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Mahmood, S., Taketa, K., Imai, K., Kajihara, Y., Imai, S., Yokobayashi, T., Yamamoto, S., Sato, M., Omori, H., & Manabe, K. (1998). Association of Fatty Liver with Increased Ratio of Visceral to Subcutaneous Adipose Tissue in Obese Men. Acta medica Okayama, 52(4), 225-231.