Association of elevated plasma B-type natriuretic peptide levels with paroxysmal atrial fibrillation in patients with nonobstructive hypertrophic cardiomyopathy

Hiroko Matsuura, Takashi Murakami, Kazuyoshi Hina, Keizo Yamamoto, Hiroshi Kawamura, Taiji Sogo, Ryoko Shinohata, Shinichi Usui, Yoshifumi Ninomiya, Shozo Kusachi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objectives: To investigate the relationship between the plasma B-type natriuretic peptide (BNP) level and the occurrence of atrial fibrillation (AF) in nonobstructive hypertrophic cardiomyopathy (HCM) patients. Methods: Patients (n = 97) were classified into chronic AF (CAF; n = 14), paroxysmal AF (PAF; n = 18) and normal sinus rhythm (NSR; n = 65) groups. The plasma BNP values were analyzed with logarithmic transformation. Results: The PAF group showed significantly higher plasma BNP levels than the NSR group [mean (range; - l SD and + 1 SD); 248.3 (143.5, 429.5) vs. 78.2 (27.9, 218.8 ng/L), p < 0.0001]. The CAF group also showed significantly higher plasma BNP levels than the NSR group [291.1 (161.4, 524.8 ng/L), p < 0.0001]. Multivariate analysis with other clinical factors selected association of PAF as one of the factors that increased the plasma BNP level. Conclusions: The present study indicated that plasma BNP level is clinically useful for identification of nonobstructive HCM patients who have a risk of PAF.

Original languageEnglish
Pages (from-to)134-139
Number of pages6
JournalClinical Biochemistry
Volume41
Issue number3
DOIs
Publication statusPublished - Feb 1 2008

Keywords

  • Cardiomyopathy
  • Clinical study
  • Enzyme immunoassay
  • Peptide
  • Sensitivity and specificity
  • Tachyarrhythmia

ASJC Scopus subject areas

  • Clinical Biochemistry

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