Abstract
Objectives: To investigate the relationship between the plasma B-type natriuretic peptide (BNP) level and the occurrence of atrial fibrillation (AF) in nonobstructive hypertrophic cardiomyopathy (HCM) patients. Methods: Patients (n = 97) were classified into chronic AF (CAF; n = 14), paroxysmal AF (PAF; n = 18) and normal sinus rhythm (NSR; n = 65) groups. The plasma BNP values were analyzed with logarithmic transformation. Results: The PAF group showed significantly higher plasma BNP levels than the NSR group [mean (range; - l SD and + 1 SD); 248.3 (143.5, 429.5) vs. 78.2 (27.9, 218.8 ng/L), p < 0.0001]. The CAF group also showed significantly higher plasma BNP levels than the NSR group [291.1 (161.4, 524.8 ng/L), p < 0.0001]. Multivariate analysis with other clinical factors selected association of PAF as one of the factors that increased the plasma BNP level. Conclusions: The present study indicated that plasma BNP level is clinically useful for identification of nonobstructive HCM patients who have a risk of PAF.
Original language | English |
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Pages (from-to) | 134-139 |
Number of pages | 6 |
Journal | Clinical Biochemistry |
Volume | 41 |
Issue number | 3 |
DOIs | |
Publication status | Published - Feb 2008 |
Keywords
- Cardiomyopathy
- Clinical study
- Enzyme immunoassay
- Peptide
- Sensitivity and specificity
- Tachyarrhythmia
ASJC Scopus subject areas
- Clinical Biochemistry