Association of asthma with serum IgE levels and aging. Bronchoalveolar cells and the release of histamine and leukotrienes, LTC4 and LTB4, from leucocytes

Yoshiro Tanizaki, Hikaru Kitani, Morihiro Okazaki, Takashi Mifune, Fumihiro Mitsunobu, Ikuro Kimura

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Association of age and serum IgE levels with pathophysiology of asthma was examined in 64 patients with asthma. Positive RAST scores of 2+ or more to inhaled allergens were significantly higher in patients with high serum IgE than in those with low serum IgE in 4059 year-olds. The proportion of BAL lymphocytes was significantly higher in patients over age 60 with high serum IgE compared with those between 20 and 39 and between 40 and 59 with either high or low serum IgE. The release of histamine or leukotriene C4, from leucocytes was significantly higher in patients with high serum IgE than in those with low serum IgE in 20-39 (both histamine and LTC4) and over 60 year-olds (histamine).

Original languageEnglish
Pages (from-to)44-51
Number of pages8
JournalJapanese Journal of Clinical Immunology
Volume16
Issue number1
DOIs
Publication statusPublished - 1993

Keywords

  • BAL cells
  • asthma
  • histamine
  • leukotrienes
  • serum IgE

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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