TY - JOUR
T1 - Association of alcohol consumption with fat deposition in a community-based sample of Japanese men
T2 - The Shiga epidemiological study of subclinical atherosclerosis (SESSA)
AU - Sumi, Masaki
AU - Hisamatsu, Takashi
AU - Fujiyoshi, Akira
AU - Kadota, Aya
AU - Miyagawa, Naoko
AU - Kondo, Keiko
AU - Kadowaki, Sayaka
AU - Suzuki, Sentaro
AU - Torii, Sayuki
AU - Zaid, Maryam
AU - Sato, Atsushi
AU - Arima, Hisatomi
AU - Terada, Tomohiro
AU - Miura, Katsuyuki
AU - Ueshima, Hirotsugu
AU - Horie, Minoru
AU - Nakano, Yasutaka
AU - Yamamoto, Takashi
AU - Hayashi, Hideki
AU - Ogawa, Emiko
AU - Maegawa, Hiroshi
AU - Miyazawa, Itsuko
AU - Murata, Kiyoshi
AU - Mitsunami, Kenichi
AU - Nozaki, Kazuhiko
AU - Tooyama, Ikuo
AU - Shiino, Akihiko
AU - Tsuru, Teruhiko
AU - Ogita, Hisakazu
AU - Shimizu, Akio
AU - Miyamatsu, Naomi
AU - Kita, Toru
AU - Kimura, Takeshi
AU - Nishio, Yoshihiko
AU - Nakamura, Yasuyuki
AU - Okamura, Tomonori
AU - Sekikawa, Akira
AU - Barinas-Mitchell, Emma Jm
AU - Edmundowicz, Daniel
AU - Ohkubo, Takayoshi
AU - Hozawa, Atsushi
AU - Miyagi, Sendai
AU - Murakami, Yoshitaka
AU - Okuda, Nagako
AU - Kita, Yoshikuni
AU - Higashiyama, Aya
AU - Nagasawa, Shinya
AU - Azuma, Koichiro
AU - Yanagita, Masahiko
AU - Abbott, Robert D.
AU - Ohno, Seiko
AU - Takashima, Naoyuki
AU - Kadowaki, Takashi
AU - Saito, Yoshino
AU - Ito, Takahiro
AU - Satoh, Atsushi
AU - Yamazoe, Masahiro
N1 - Funding Information:
Source of funding: This research was supported by Grants-in-aid for Scientific Research (A) 13307016, (A) 17209023, (A) 21249043, (A) 23249036, (A) 25253046, (A) 15H02528, and (B) 26293140, (B) 24790616, (B) 21790579 from the Ministry of Education, Culture, Sports, Science, and Technology Japan; and by Glaxo-Smith Klein.
Publisher Copyright:
© 2018 Masaki Sumi et al.
PY - 2019/6
Y1 - 2019/6
N2 - Background: Excessive alcohol intake has been shown to be associated with cardiovascular disease via metabolic pathways. However, the relationship between alcohol intake and obesity has not been fully elucidated. We aimed to examine the association of alcohol consumption with fat deposition and anthropometric measures. Methods: From 2006–2008, we conducted a cross-sectional study in a population-based sample of Japanese men aged 40 through 79 years. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography imaging. Based on a questionnaire, we classified participants into five groups according to weekly alcohol consumption, excluding former drinkers: Non-drinkers (0 g=week), 0.1–160.9, 161–321.9, 322–482.9, and ≥483 g=week. Multivariable linear regression was used to estimate adjusted means of obesity indices for each group. Results: We analyzed 998 men (mean age and body mass index [BMI], 63.8 years and 23.6 kg=m2, respectively). Higher weekly alcohol consumption was strongly and significantly associated with higher abdominal VAT area, percentage of VAT, and VATto- SAT ratio (all P for trend <0.001), and also with waist circumferences and waist-to-hip ratio (P for trend = 0.042 and 0.007, respectively). These associations remained significant after further adjustment for BMI, whereas alcohol consumption had no significant association with abdominal SAT area. Conclusions: Higher alcohol consumption was associated with higher VAT area, VAT%, and VAT-to-SAT ratio, independent of confounders, including BMI, in general Japanese men. These results suggest that alcohol consumption may have a potential adverse effect on visceral fat deposition.
AB - Background: Excessive alcohol intake has been shown to be associated with cardiovascular disease via metabolic pathways. However, the relationship between alcohol intake and obesity has not been fully elucidated. We aimed to examine the association of alcohol consumption with fat deposition and anthropometric measures. Methods: From 2006–2008, we conducted a cross-sectional study in a population-based sample of Japanese men aged 40 through 79 years. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography imaging. Based on a questionnaire, we classified participants into five groups according to weekly alcohol consumption, excluding former drinkers: Non-drinkers (0 g=week), 0.1–160.9, 161–321.9, 322–482.9, and ≥483 g=week. Multivariable linear regression was used to estimate adjusted means of obesity indices for each group. Results: We analyzed 998 men (mean age and body mass index [BMI], 63.8 years and 23.6 kg=m2, respectively). Higher weekly alcohol consumption was strongly and significantly associated with higher abdominal VAT area, percentage of VAT, and VATto- SAT ratio (all P for trend <0.001), and also with waist circumferences and waist-to-hip ratio (P for trend = 0.042 and 0.007, respectively). These associations remained significant after further adjustment for BMI, whereas alcohol consumption had no significant association with abdominal SAT area. Conclusions: Higher alcohol consumption was associated with higher VAT area, VAT%, and VAT-to-SAT ratio, independent of confounders, including BMI, in general Japanese men. These results suggest that alcohol consumption may have a potential adverse effect on visceral fat deposition.
KW - Alcohol consumption
KW - Anthropometric obesity indice
KW - Fat deposition
KW - Visceral adipose tissue
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U2 - 10.2188/jea.JE20170191
DO - 10.2188/jea.JE20170191
M3 - Article
C2 - 29848904
AN - SCOPUS:85067349380
SN - 0917-5040
VL - 29
SP - 205
EP - 212
JO - Journal of Epidemiology
JF - Journal of Epidemiology
IS - 6
ER -
