Association between Vitamin B group supplementation with changes in % flow mediated dilatation and plasma homocysteine levels: A randomized controlled trial

Koutatsu Maruyama, Ehab S. Eshak, Minako Kinuta, Masanori Nagao, Renzhe Cui, Hironori Imano, Tetsuya Ohira, Hiroyasu Iso

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

There is limited evidence examining the association between B vitamin supplementation and improved endothelial function via lowering plasma homocysteine levels. This study investigated whether lowdose B vitamin supplementation improves endo thelial dysfunction in Japanese adults with one or more compo nents of metabolic syndrome. A randomized, controlled, crossover trial, without a washout period or blinding of subjects, was conducted from MaySeptember, 2010. The subjects were 127 Japanese men and women aged 40–65 years who had at least one component of metabolic syndrome without medication. Participants took a supplement drink for two months but were divided into early intervention or later intervention groups. The flowmediated dilatation, plasma homocysteine level, serum B vitamins, and vitamin C levels were measured. A significant increase in serum B vitamins and vitamin C levels, and a reduction in plasma homocysteine levels were observed. The mean serum homocysteine level pre and postintervention was 9.8 and 8.2 µmol/L in the early intervention group and 10.8 and 7.4 µmol/L in the later intervention group (p<0.01). However, no significant changes in flowmediated dilatation was found. Lowdose multi vitamin supplementation including B vitamins is associated with a significant reduction in plasma homocysteine levels among patients with one or more components of metabolic syndrome. This study was registered at the University Hospital Medical Information Network (UMIN) centre, and has the identifier UMIN000004436.

Original languageEnglish
Pages (from-to)243-249
Number of pages7
Journaljournal of clinical biochemistry and nutrition
Volume64
Issue number3
DOIs
Publication statusPublished - 2019
Externally publishedYes

Keywords

  • Clinical trial
  • Folate
  • Plasma homocysteine
  • Vitamin B12
  • Vitamin B6

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

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