TY - JOUR
T1 - Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography
AU - Hotta, Kikuko
AU - Kitamoto, Aya
AU - Kitamoto, Takuya
AU - Mizusawa, Seiho
AU - Teranishi, Hajime
AU - So, Rina
AU - Matsuo, Tomoaki
AU - Nakata, Yoshio
AU - Hyogo, Hideyuki
AU - Ochi, Hidenori
AU - Nakamura, Takahiro
AU - Kamohara, Seika
AU - Miyatake, Nobuyuki
AU - Kotani, Kazuaki
AU - Komatsu, Ryoya
AU - Itoh, Naoto
AU - Mineo, Ikuo
AU - Wada, Jun
AU - Yoneda, Masato
AU - Nakajima, Atsushi
AU - Funahashi, Tohru
AU - Miyazaki, Shigeru
AU - Tokunaga, Katsuto
AU - Masuzaki, Hiroaki
AU - Ueno, Takato
AU - Chayama, Kazuaki
AU - Hamaguchi, Kazuyuki
AU - Yamada, Kentaro
AU - Hanafusa, Toshiaki
AU - Oikawa, Shinichi
AU - Yoshimatsu, Hironobu
AU - Sakata, Toshiie
AU - Tanaka, Kiyoji
AU - Matsuzawa, Yuji
AU - Nakao, Kazuwa
AU - Sekine, Akihiro
PY - 2012/5
Y1 - 2012/5
N2 - Visceral fat accumulation has an important role in the development of several metabolic disorders, such as type 2 diabetes, dyslipidemia and hypertension. New genetic loci that contribute to the development of type 2 diabetes have been identified by genome-wide association studies. To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography for measurements of visceral fat area (VFA) and subcutaneous fat area (SFA) for the following single-nucleotide polymorphisms (SNPs): NOTCH2 rs10923931, THADA rs7578597, PPARG rs1801282, ADAMTS9 rs4607103, IGF2BP2 rs1470579, VEGFA rs9472138, JAZF1 rs864745, CDKN2A/CDKN2B rs564398 and rs10811661, HHEX rs1111875 and rs5015480, TCF7L2 rs7901695, KCNQ1 rs2237892, KCNJ11 rs5215 and rs5219, EXT2 rs1113132, rs11037909, and rs3740878, MTNR1B rs10830963, DCD rs1153188, TSPAN8/LGR5 rs7961581, and FTO rs8050136 and rs9939609. None of the above SNPs were significantly associated with VFA. The FTO rs8050136 and rs9939609 risk alleles exhibited significant associations with body mass index (BMI; P=0.00088 and P=0.0010, respectively) and SFA (P=0.00013 and P=0.00017, respectively). No other SNPs were significantly associated with BMI or SFA. Our results suggest that two SNPs in the FTO gene are associated with subcutaneous fat accumulation. The contributions of other SNPs are inconclusive because of a limitation of the sample power.
AB - Visceral fat accumulation has an important role in the development of several metabolic disorders, such as type 2 diabetes, dyslipidemia and hypertension. New genetic loci that contribute to the development of type 2 diabetes have been identified by genome-wide association studies. To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography for measurements of visceral fat area (VFA) and subcutaneous fat area (SFA) for the following single-nucleotide polymorphisms (SNPs): NOTCH2 rs10923931, THADA rs7578597, PPARG rs1801282, ADAMTS9 rs4607103, IGF2BP2 rs1470579, VEGFA rs9472138, JAZF1 rs864745, CDKN2A/CDKN2B rs564398 and rs10811661, HHEX rs1111875 and rs5015480, TCF7L2 rs7901695, KCNQ1 rs2237892, KCNJ11 rs5215 and rs5219, EXT2 rs1113132, rs11037909, and rs3740878, MTNR1B rs10830963, DCD rs1153188, TSPAN8/LGR5 rs7961581, and FTO rs8050136 and rs9939609. None of the above SNPs were significantly associated with VFA. The FTO rs8050136 and rs9939609 risk alleles exhibited significant associations with body mass index (BMI; P=0.00088 and P=0.0010, respectively) and SFA (P=0.00013 and P=0.00017, respectively). No other SNPs were significantly associated with BMI or SFA. Our results suggest that two SNPs in the FTO gene are associated with subcutaneous fat accumulation. The contributions of other SNPs are inconclusive because of a limitation of the sample power.
KW - FTO
KW - Japanese subjects
KW - computed tomography
KW - subcutaneous fat area
KW - type 2 diabetes
KW - visceral fat area
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U2 - 10.1038/jhg.2012.21
DO - 10.1038/jhg.2012.21
M3 - Article
C2 - 22377712
AN - SCOPUS:84861639680
VL - 57
SP - 305
EP - 310
JO - Jinrui idengaku zasshi. The Japanese journal of human genetics
JF - Jinrui idengaku zasshi. The Japanese journal of human genetics
SN - 1434-5161
IS - 5
ER -
