Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography

Kikuko Hotta; Aya Kitamoto; Takuya Kitamoto; Seiho Mizusawa; Hajime Teranishi; Rina So; Tomoaki Matsuo; Yoshio Nakata; Hideyuki Hyogo; Hidenori Ochi; Takahiro Nakamura; Seika Kamohara; Nobuyuki Miyatake; Kazuaki Kotani; Ryoya Komatsu; Naoto Itoh; Ikuo Mineo; Jun Wada; Masato Yoneda; Atsushi Nakajima; Tohru Funahashi; Shigeru Miyazaki; Katsuto Tokunaga; Hiroaki Masuzaki; Takato Ueno; Kazuaki Chayama; Kazuyuki Hamaguchi; Kentaro Yamada; Toshiaki Hanafusa; Shinichi Oikawa; Hironobu Yoshimatsu; Toshiie Sakata; Kiyoji Tanaka; Yuji Matsuzawa; Kazuwa Nakao; Akihiro Sekine

doi:10.1038/jhg.2012.21

Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography

Kikuko Hotta, Aya Kitamoto, Takuya Kitamoto, Seiho Mizusawa, Hajime Teranishi, Rina So, Tomoaki Matsuo, Yoshio Nakata, Hideyuki Hyogo, Hidenori Ochi, Takahiro Nakamura, Seika Kamohara, Nobuyuki Miyatake, Kazuaki Kotani, Ryoya Komatsu, Naoto Itoh, Ikuo Mineo, Jun Wada, Masato Yoneda, Atsushi NakajimaTohru Funahashi, Shigeru Miyazaki, Katsuto Tokunaga, Hiroaki Masuzaki, Takato Ueno, Kazuaki Chayama, Kazuyuki Hamaguchi, Kentaro Yamada, Toshiaki Hanafusa, Shinichi Oikawa, Hironobu Yoshimatsu, Toshiie Sakata, Kiyoji Tanaka, Yuji Matsuzawa, Kazuwa Nakao, Akihiro Sekine

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Visceral fat accumulation has an important role in the development of several metabolic disorders, such as type 2 diabetes, dyslipidemia and hypertension. New genetic loci that contribute to the development of type 2 diabetes have been identified by genome-wide association studies. To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography for measurements of visceral fat area (VFA) and subcutaneous fat area (SFA) for the following single-nucleotide polymorphisms (SNPs): NOTCH2 rs10923931, THADA rs7578597, PPARG rs1801282, ADAMTS9 rs4607103, IGF2BP2 rs1470579, VEGFA rs9472138, JAZF1 rs864745, CDKN2A/CDKN2B rs564398 and rs10811661, HHEX rs1111875 and rs5015480, TCF7L2 rs7901695, KCNQ1 rs2237892, KCNJ11 rs5215 and rs5219, EXT2 rs1113132, rs11037909, and rs3740878, MTNR1B rs10830963, DCD rs1153188, TSPAN8/LGR5 rs7961581, and FTO rs8050136 and rs9939609. None of the above SNPs were significantly associated with VFA. The FTO rs8050136 and rs9939609 risk alleles exhibited significant associations with body mass index (BMI; P=0.00088 and P=0.0010, respectively) and SFA (P=0.00013 and P=0.00017, respectively). No other SNPs were significantly associated with BMI or SFA. Our results suggest that two SNPs in the FTO gene are associated with subcutaneous fat accumulation. The contributions of other SNPs are inconclusive because of a limitation of the sample power.

Original language	English
Pages (from-to)	305-310
Number of pages	6
Journal	Journal of Human Genetics
Volume	57
Issue number	5
DOIs	https://doi.org/10.1038/jhg.2012.21
Publication status	Published - May 2012

Keywords

FTO
Japanese subjects
computed tomography
subcutaneous fat area
type 2 diabetes
visceral fat area

ASJC Scopus subject areas

Genetics
Genetics(clinical)

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

Access to Document

10.1038/jhg.2012.21

Fingerprint Dive into the research topics of 'Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography'. Together they form a unique fingerprint.

Cite this

Hotta, K., Kitamoto, A., Kitamoto, T., Mizusawa, S., Teranishi, H., So, R., Matsuo, T., Nakata, Y., Hyogo, H., Ochi, H., Nakamura, T., Kamohara, S., Miyatake, N., Kotani, K., Komatsu, R., Itoh, N., Mineo, I., Wada, J., Yoneda, M., ... Sekine, A. (2012). Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography. Journal of Human Genetics, 57(5), 305-310. https://doi.org/10.1038/jhg.2012.21

Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography. / Hotta, Kikuko; Kitamoto, Aya; Kitamoto, Takuya; Mizusawa, Seiho; Teranishi, Hajime; So, Rina; Matsuo, Tomoaki; Nakata, Yoshio; Hyogo, Hideyuki; Ochi, Hidenori; Nakamura, Takahiro; Kamohara, Seika; Miyatake, Nobuyuki; Kotani, Kazuaki; Komatsu, Ryoya; Itoh, Naoto; Mineo, Ikuo; Wada, Jun; Yoneda, Masato; Nakajima, Atsushi; Funahashi, Tohru; Miyazaki, Shigeru; Tokunaga, Katsuto; Masuzaki, Hiroaki; Ueno, Takato; Chayama, Kazuaki; Hamaguchi, Kazuyuki; Yamada, Kentaro; Hanafusa, Toshiaki; Oikawa, Shinichi; Yoshimatsu, Hironobu; Sakata, Toshiie; Tanaka, Kiyoji; Matsuzawa, Yuji; Nakao, Kazuwa; Sekine, Akihiro.

In: Journal of Human Genetics, Vol. 57, No. 5, 05.2012, p. 305-310.

Research output: Contribution to journal › Article › peer-review

Hotta, K, Kitamoto, A, Kitamoto, T, Mizusawa, S, Teranishi, H, So, R, Matsuo, T, Nakata, Y, Hyogo, H, Ochi, H, Nakamura, T, Kamohara, S, Miyatake, N, Kotani, K, Komatsu, R, Itoh, N, Mineo, I, Wada, J, Yoneda, M, Nakajima, A, Funahashi, T, Miyazaki, S, Tokunaga, K, Masuzaki, H, Ueno, T, Chayama, K, Hamaguchi, K, Yamada, K, Hanafusa, T, Oikawa, S, Yoshimatsu, H, Sakata, T, Tanaka, K, Matsuzawa, Y, Nakao, K & Sekine, A 2012, 'Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography', Journal of Human Genetics, vol. 57, no. 5, pp. 305-310. https://doi.org/10.1038/jhg.2012.21

Hotta, Kikuko ; Kitamoto, Aya ; Kitamoto, Takuya ; Mizusawa, Seiho ; Teranishi, Hajime ; So, Rina ; Matsuo, Tomoaki ; Nakata, Yoshio ; Hyogo, Hideyuki ; Ochi, Hidenori ; Nakamura, Takahiro ; Kamohara, Seika ; Miyatake, Nobuyuki ; Kotani, Kazuaki ; Komatsu, Ryoya ; Itoh, Naoto ; Mineo, Ikuo ; Wada, Jun ; Yoneda, Masato ; Nakajima, Atsushi ; Funahashi, Tohru ; Miyazaki, Shigeru ; Tokunaga, Katsuto ; Masuzaki, Hiroaki ; Ueno, Takato ; Chayama, Kazuaki ; Hamaguchi, Kazuyuki ; Yamada, Kentaro ; Hanafusa, Toshiaki ; Oikawa, Shinichi ; Yoshimatsu, Hironobu ; Sakata, Toshiie ; Tanaka, Kiyoji ; Matsuzawa, Yuji ; Nakao, Kazuwa ; Sekine, Akihiro. / Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography. In: Journal of Human Genetics. 2012 ; Vol. 57, No. 5. pp. 305-310.

@article{b14630b01be94579b1888d28a330124e,

title = "Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography",

abstract = "Visceral fat accumulation has an important role in the development of several metabolic disorders, such as type 2 diabetes, dyslipidemia and hypertension. New genetic loci that contribute to the development of type 2 diabetes have been identified by genome-wide association studies. To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography for measurements of visceral fat area (VFA) and subcutaneous fat area (SFA) for the following single-nucleotide polymorphisms (SNPs): NOTCH2 rs10923931, THADA rs7578597, PPARG rs1801282, ADAMTS9 rs4607103, IGF2BP2 rs1470579, VEGFA rs9472138, JAZF1 rs864745, CDKN2A/CDKN2B rs564398 and rs10811661, HHEX rs1111875 and rs5015480, TCF7L2 rs7901695, KCNQ1 rs2237892, KCNJ11 rs5215 and rs5219, EXT2 rs1113132, rs11037909, and rs3740878, MTNR1B rs10830963, DCD rs1153188, TSPAN8/LGR5 rs7961581, and FTO rs8050136 and rs9939609. None of the above SNPs were significantly associated with VFA. The FTO rs8050136 and rs9939609 risk alleles exhibited significant associations with body mass index (BMI; P=0.00088 and P=0.0010, respectively) and SFA (P=0.00013 and P=0.00017, respectively). No other SNPs were significantly associated with BMI or SFA. Our results suggest that two SNPs in the FTO gene are associated with subcutaneous fat accumulation. The contributions of other SNPs are inconclusive because of a limitation of the sample power.",

keywords = "FTO, Japanese subjects, computed tomography, subcutaneous fat area, type 2 diabetes, visceral fat area",

author = "Kikuko Hotta and Aya Kitamoto and Takuya Kitamoto and Seiho Mizusawa and Hajime Teranishi and Rina So and Tomoaki Matsuo and Yoshio Nakata and Hideyuki Hyogo and Hidenori Ochi and Takahiro Nakamura and Seika Kamohara and Nobuyuki Miyatake and Kazuaki Kotani and Ryoya Komatsu and Naoto Itoh and Ikuo Mineo and Jun Wada and Masato Yoneda and Atsushi Nakajima and Tohru Funahashi and Shigeru Miyazaki and Katsuto Tokunaga and Hiroaki Masuzaki and Takato Ueno and Kazuaki Chayama and Kazuyuki Hamaguchi and Kentaro Yamada and Toshiaki Hanafusa and Shinichi Oikawa and Hironobu Yoshimatsu and Toshiie Sakata and Kiyoji Tanaka and Yuji Matsuzawa and Kazuwa Nakao and Akihiro Sekine",

year = "2012",

month = may,

doi = "10.1038/jhg.2012.21",

language = "English",

volume = "57",

pages = "305--310",

journal = "Jinrui idengaku zasshi. The Japanese journal of human genetics",

issn = "1434-5161",

publisher = "Nature Publishing Group",

number = "5",

}

TY - JOUR

T1 - Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography

AU - Hotta, Kikuko

AU - Kitamoto, Aya

AU - Kitamoto, Takuya

AU - Mizusawa, Seiho

AU - Teranishi, Hajime

AU - So, Rina

AU - Matsuo, Tomoaki

AU - Nakata, Yoshio

AU - Hyogo, Hideyuki

AU - Ochi, Hidenori

AU - Nakamura, Takahiro

AU - Kamohara, Seika

AU - Miyatake, Nobuyuki

AU - Kotani, Kazuaki

AU - Komatsu, Ryoya

AU - Itoh, Naoto

AU - Mineo, Ikuo

AU - Wada, Jun

AU - Yoneda, Masato

AU - Nakajima, Atsushi

AU - Funahashi, Tohru

AU - Miyazaki, Shigeru

AU - Tokunaga, Katsuto

AU - Masuzaki, Hiroaki

AU - Ueno, Takato

AU - Chayama, Kazuaki

AU - Hamaguchi, Kazuyuki

AU - Yamada, Kentaro

AU - Hanafusa, Toshiaki

AU - Oikawa, Shinichi

AU - Yoshimatsu, Hironobu

AU - Sakata, Toshiie

AU - Tanaka, Kiyoji

AU - Matsuzawa, Yuji

AU - Nakao, Kazuwa

AU - Sekine, Akihiro

PY - 2012/5

Y1 - 2012/5

N2 - Visceral fat accumulation has an important role in the development of several metabolic disorders, such as type 2 diabetes, dyslipidemia and hypertension. New genetic loci that contribute to the development of type 2 diabetes have been identified by genome-wide association studies. To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography for measurements of visceral fat area (VFA) and subcutaneous fat area (SFA) for the following single-nucleotide polymorphisms (SNPs): NOTCH2 rs10923931, THADA rs7578597, PPARG rs1801282, ADAMTS9 rs4607103, IGF2BP2 rs1470579, VEGFA rs9472138, JAZF1 rs864745, CDKN2A/CDKN2B rs564398 and rs10811661, HHEX rs1111875 and rs5015480, TCF7L2 rs7901695, KCNQ1 rs2237892, KCNJ11 rs5215 and rs5219, EXT2 rs1113132, rs11037909, and rs3740878, MTNR1B rs10830963, DCD rs1153188, TSPAN8/LGR5 rs7961581, and FTO rs8050136 and rs9939609. None of the above SNPs were significantly associated with VFA. The FTO rs8050136 and rs9939609 risk alleles exhibited significant associations with body mass index (BMI; P=0.00088 and P=0.0010, respectively) and SFA (P=0.00013 and P=0.00017, respectively). No other SNPs were significantly associated with BMI or SFA. Our results suggest that two SNPs in the FTO gene are associated with subcutaneous fat accumulation. The contributions of other SNPs are inconclusive because of a limitation of the sample power.

AB - Visceral fat accumulation has an important role in the development of several metabolic disorders, such as type 2 diabetes, dyslipidemia and hypertension. New genetic loci that contribute to the development of type 2 diabetes have been identified by genome-wide association studies. To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography for measurements of visceral fat area (VFA) and subcutaneous fat area (SFA) for the following single-nucleotide polymorphisms (SNPs): NOTCH2 rs10923931, THADA rs7578597, PPARG rs1801282, ADAMTS9 rs4607103, IGF2BP2 rs1470579, VEGFA rs9472138, JAZF1 rs864745, CDKN2A/CDKN2B rs564398 and rs10811661, HHEX rs1111875 and rs5015480, TCF7L2 rs7901695, KCNQ1 rs2237892, KCNJ11 rs5215 and rs5219, EXT2 rs1113132, rs11037909, and rs3740878, MTNR1B rs10830963, DCD rs1153188, TSPAN8/LGR5 rs7961581, and FTO rs8050136 and rs9939609. None of the above SNPs were significantly associated with VFA. The FTO rs8050136 and rs9939609 risk alleles exhibited significant associations with body mass index (BMI; P=0.00088 and P=0.0010, respectively) and SFA (P=0.00013 and P=0.00017, respectively). No other SNPs were significantly associated with BMI or SFA. Our results suggest that two SNPs in the FTO gene are associated with subcutaneous fat accumulation. The contributions of other SNPs are inconclusive because of a limitation of the sample power.

KW - FTO

KW - Japanese subjects

KW - computed tomography

KW - subcutaneous fat area

KW - type 2 diabetes

KW - visceral fat area

UR - http://www.scopus.com/inward/record.url?scp=84861639680&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861639680&partnerID=8YFLogxK

U2 - 10.1038/jhg.2012.21

DO - 10.1038/jhg.2012.21

M3 - Article

C2 - 22377712

AN - SCOPUS:84861639680

VL - 57

SP - 305

EP - 310

JO - Jinrui idengaku zasshi. The Japanese journal of human genetics

JF - Jinrui idengaku zasshi. The Japanese journal of human genetics

SN - 1434-5161

IS - 5

ER -

Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Cite this