Association between the dopamine D2 receptor A2/A2 genotype and smoking behavior in the Japanese

K. Yoshida, N. Hamajima, K. I. Kozaki, H. Saito, K. Maeno, T. Sugiura, K. Ookuma, T. Takahashi

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

For the study presented here, we investigated possible links between the dopamine D2 receptor (DRD2) TaqIA genotype (DRD2*A) and smoking behavior in a total of 332 Japanese individuals. For the first time, functional insertion/deletion polymorphism (-141C Ins/Del) in the DRD2 promoter was also examined in relation to smoking behavior. The distribution of the DRD2*A genotype was significantly different among current, former, and never-smokers (P = 0.001; X2 test), and smoking appeared to be associated with the DRD2 A2/A2 genotype, showing marked contrast to previous reports for non-Hispanic whites in the United States. Multivariate logistic regression analysis incorporating age, sex, genotype, and smoking status as variables revealed that DRD2 A2/A2 genotype was significantly associated with an increased risk of predisposition to smoking behavior in the Japanese (odds ratio, 3.680; 95% confidence interval, 1.499-9.052). In contrast, such an increased risk was not observed in terms of association with the -141C Ins/Del polymorphism. These findings suggest an association of the DRD2*A genotype with an increased risk of being predisposed to smoking behavior in the Japanese and suggest the possible existence of ethnic group-specific differences, which warrant additional studies on the underlying molecular mechanism.

Original languageEnglish
Pages (from-to)403-405
Number of pages3
JournalCancer Epidemiology Biomarkers and Prevention
Volume10
Issue number4
Publication statusPublished - Aug 14 2001

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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    Yoshida, K., Hamajima, N., Kozaki, K. I., Saito, H., Maeno, K., Sugiura, T., Ookuma, K., & Takahashi, T. (2001). Association between the dopamine D2 receptor A2/A2 genotype and smoking behavior in the Japanese. Cancer Epidemiology Biomarkers and Prevention, 10(4), 403-405.