Association between serum γ-glutamyltransferase and oxidative stress related factors

Tomoko Takigawa, Yuri Hibino, Shingo Kimura, Hiroshi Yamauchi, Bingling Wang, Dahong Wang, Keiki Ogino

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background/Aims: To investigate the main factors correlated with the serum γ-glutamyltransferase activity. Methodology: We measured serum γ-glutamyltransferase activity in 248 healthy Japanese people and determined its correlations with serum antioxidants, other plasma or serum factors, urinary 8-hydroxydeoxyguanine, and lifestyle factors. Results: The mean serum γ-glutamyltransferase activity was 29 IU/L. γ- Glutamyltransferase activities of males and persons older than 45 years were significantly higher than each counterpart. γ-Glutamyltransferase levels increased significantly with the number of cigarettes smoked per day and the frequency of alcohol consumption except for the persons who did not take alcohol. Additionally, γ-glutamyltransferase significantly correlated with urinary 8-hydroxydeoxyguanine, and with more blood factors including serum tocopherols, carotenoids, antioxidative enzymes, lipid peroxide, and free fatty acids than urinary 8-hydroxydeoxyguanine did. In multiple regression analyses, γ-glutamyltransferase had significant associations with retinol, 8-hydroxydeoxyguanine, docosahexaenoic acid, and cigarette smoking. Conclusions: Our present findings support the hypothesis that γ-glutamyltransferase can be used as a marker related with oxidative stress.

Original languageEnglish
Pages (from-to)50-53
Number of pages4
JournalHepato-Gastroenterology
Volume55
Issue number81
Publication statusPublished - Jan 2008

Fingerprint

Oxidative Stress
Serum
Tocopherols
Docosahexaenoic Acids
Lipid Peroxides
Carotenoids
Vitamin A
Nonesterified Fatty Acids
Tobacco Products
Alcohol Drinking
Life Style
Antioxidants
Smoking
Regression Analysis
Alcohols
8-oxo-7,8-dihydrodeoxyguanine
Enzymes

Keywords

  • Antioxidants
  • Biomarker
  • Cross-sectional study
  • Lifestyle factors
  • Retinol

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Takigawa, T., Hibino, Y., Kimura, S., Yamauchi, H., Wang, B., Wang, D., & Ogino, K. (2008). Association between serum γ-glutamyltransferase and oxidative stress related factors. Hepato-Gastroenterology, 55(81), 50-53.

Association between serum γ-glutamyltransferase and oxidative stress related factors. / Takigawa, Tomoko; Hibino, Yuri; Kimura, Shingo; Yamauchi, Hiroshi; Wang, Bingling; Wang, Dahong; Ogino, Keiki.

In: Hepato-Gastroenterology, Vol. 55, No. 81, 01.2008, p. 50-53.

Research output: Contribution to journalArticle

Takigawa, T, Hibino, Y, Kimura, S, Yamauchi, H, Wang, B, Wang, D & Ogino, K 2008, 'Association between serum γ-glutamyltransferase and oxidative stress related factors', Hepato-Gastroenterology, vol. 55, no. 81, pp. 50-53.
Takigawa T, Hibino Y, Kimura S, Yamauchi H, Wang B, Wang D et al. Association between serum γ-glutamyltransferase and oxidative stress related factors. Hepato-Gastroenterology. 2008 Jan;55(81):50-53.
Takigawa, Tomoko ; Hibino, Yuri ; Kimura, Shingo ; Yamauchi, Hiroshi ; Wang, Bingling ; Wang, Dahong ; Ogino, Keiki. / Association between serum γ-glutamyltransferase and oxidative stress related factors. In: Hepato-Gastroenterology. 2008 ; Vol. 55, No. 81. pp. 50-53.
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