Association between schizoprenia and a polymorphism of cytosolic phosholipase A2 gene

Y. Takehisa, H. Ujike, Manabu Takaki, Y. Anaka, Y. Fujiwara, T. Takeda, S. Otsuki, S. Kuroda

Research output: Contribution to journalArticle

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Abstract

Cytosolic phosholipase A2 (cPLA2) is a ubiquitous enzyme that produce arachinoid acid (AA), a second messenger, by cleaving phosholipids. Serum, plasma and platelet cPLA2 activity has been reported to be significantly increased in patients with schizophrenia as compared to controls. A reduction of AA was found in red blood cell membranes of patients with schizophrenia showing predominantly negative symptoms. Peet et al. (1998) have identified a Ban I dimorphic site on the first intron of the cPLA2 gene, and reported that subjects with schizophrenia had a significant excess of the A2/A2 homozygote compared with healthy control. We examined an association between Ban I polymorphism of the cPLA2 gene and Japanese patients with schizophrenia. Distribution of genotypes, A1/A1, A1/A2 and A2/A2 type, in normal controls (N=116) was 18.5%,40.3% and 41.2%, respectively. A2/A2 genotype in Japanese subjects was more than that of Caucasian. Distribution of genotypes in schizophrenia (N=140) was 20.5%,52.8% and 26.7%, respectively. A2/A2 genotype of cPLA2 gene of schizophrenia was significantly less that of controls, however, this finding was inverse to that of Peet et al.

Original languageEnglish
Pages (from-to)534
Number of pages1
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume96
Issue number4
Publication statusPublished - Aug 7 2000

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varespladib methyl
Genes
Schizophrenia
Genotype
Acids
Homozygote
Second Messenger Systems
Introns
Blood Platelets
Erythrocytes
Cell Membrane

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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Association between schizoprenia and a polymorphism of cytosolic phosholipase A2 gene. / Takehisa, Y.; Ujike, H.; Takaki, Manabu; Anaka, Y.; Fujiwara, Y.; Takeda, T.; Otsuki, S.; Kuroda, S.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 96, No. 4, 07.08.2000, p. 534.

Research output: Contribution to journalArticle

Takehisa, Y, Ujike, H, Takaki, M, Anaka, Y, Fujiwara, Y, Takeda, T, Otsuki, S & Kuroda, S 2000, 'Association between schizoprenia and a polymorphism of cytosolic phosholipase A2 gene', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 96, no. 4, pp. 534.
Takehisa, Y. ; Ujike, H. ; Takaki, Manabu ; Anaka, Y. ; Fujiwara, Y. ; Takeda, T. ; Otsuki, S. ; Kuroda, S. / Association between schizoprenia and a polymorphism of cytosolic phosholipase A2 gene. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 2000 ; Vol. 96, No. 4. pp. 534.
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