Association between schizoprenia and a polymorphism of cytosolic phosholipase A2 gene

Y. Takehisa, H. Ujike, M. Takaki, Y. Anaka, Y. Fujiwara, T. Takeda, S. Otsuki, S. Kuroda

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1 Citation (Scopus)


Cytosolic phosholipase A2 (cPLA2) is a ubiquitous enzyme that produce arachinoid acid (AA), a second messenger, by cleaving phosholipids. Serum, plasma and platelet cPLA2 activity has been reported to be significantly increased in patients with schizophrenia as compared to controls. A reduction of AA was found in red blood cell membranes of patients with schizophrenia showing predominantly negative symptoms. Peet et al. (1998) have identified a Ban I dimorphic site on the first intron of the cPLA2 gene, and reported that subjects with schizophrenia had a significant excess of the A2/A2 homozygote compared with healthy control. We examined an association between Ban I polymorphism of the cPLA2 gene and Japanese patients with schizophrenia. Distribution of genotypes, A1/A1, A1/A2 and A2/A2 type, in normal controls (N=116) was 18.5%,40.3% and 41.2%, respectively. A2/A2 genotype in Japanese subjects was more than that of Caucasian. Distribution of genotypes in schizophrenia (N=140) was 20.5%,52.8% and 26.7%, respectively. A2/A2 genotype of cPLA2 gene of schizophrenia was significantly less that of controls, however, this finding was inverse to that of Peet et al.

Original languageEnglish
Number of pages1
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Issue number4
Publication statusPublished - Aug 7 2000

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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