Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study)

Shinji Tamaki, Yasuyuki Nakamura, Yasuharu Tabara, Tomonori Okamura, Hideyuki Kanda, Yoshikuni Kita, Takashi Kadowaki, Yasuyuki Tsujita, Tanvir Chowdhury Turin, Minoru Horie, Tetsuro Miki, Hirotsugu Ueshima

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We examined whether the A1166C polymorphism of the angiotensin II type I receptor gene (AGTR1) affects cardiovascular event occurrence in a Japanese prospective cohort study. The 2212 participants who gave informed consent for genetic analysis were enrolled in this study (the Shigaraki Study). The average observation period was 1954 days. Cardiovascular events occurred in 37 individuals (1.7%). The independent factors which specified cardiovascular events were age (hazard ratio (HR) = 1.13; 95% confidence interval (CI): 1.10-1.16; p < 0.0001) and sex (HR = 2.18; 95%CI: 1.23-3.85; p = 0.007). However, the A1166C polymorphism of AGTR1 was not a predictive factor for cardiovascular events (HR = 1.11; 95%CI: 0.61-2.02; p = 0.731).

Original languageEnglish
Pages (from-to)354-355
Number of pages2
JournalInternational Journal of Cardiology
Volume136
Issue number3
DOIs
Publication statusPublished - Aug 21 2009
Externally publishedYes

Keywords

  • A1166C polymorphism
  • AGTR1
  • Cardiovascular events
  • Prospective cohort study

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Tamaki, S., Nakamura, Y., Tabara, Y., Okamura, T., Kanda, H., Kita, Y., Kadowaki, T., Tsujita, Y., Chowdhury Turin, T., Horie, M., Miki, T., & Ueshima, H. (2009). Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study). International Journal of Cardiology, 136(3), 354-355. https://doi.org/10.1016/j.ijcard.2008.04.079