Association between Overall Survival and Activities of Daily Living in Patients with Spinal Bone Metastases

Yoshiteru Akezaki, Eiji Nakata, Masato Kikuuchi, Shinsuke Sugihara, Yoshimi Katayama, Haruyoshi Katayama, Masanori Hamada, Toshifumi Ozaki

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: This study aimed to investigate the association between overall survival (OS) and activities of daily living (ADL) in patients with skeletal-related events. In this study, 265 patients whose clinical parameters were available before radiotherapy were investigated. Methods: Age, sex, ADL, pain, the primary site, spinal level of bone metastases, spinal instability, treatment strategy, including chemotherapy or palliative treatment, and OS were investigated. ADL patients with a Barthel index of ≥90 were classified as the high ADL group, while those with a score <90 were classified as the low ADL group. For OS, patients surviving ≥160 days were classified as the non-poor prognosis group, and those who survived <160 days were classified as the poor prognosis group. Results: Age, sex, ADL, pain, the primary site, and treatment strategy for OS were different between the two groups (p < 0.1). Logistic regression analysis revealed that ADL, the primary site, and treatment strategy were significant predictors of OS (p < 0.05). High ADL, breast cancer, and chemotherapy had a positive effect on OS. Conclusions: It is suggested that improvements may be obtained by performing rehabilitation interventions to maintain and improve ADL, by constructing a system for monitoring spinal bone metastases with images before ADL decreases, and by performing interventions such as changes in treatment methods such as RT or surgery at appropriate times.

Original languageEnglish
Article number350
JournalHealthcare (Switzerland)
Volume10
Issue number2
DOIs
Publication statusPublished - Feb 2022
Externally publishedYes

Keywords

  • Activities of daily living
  • Chemotherapy
  • Overall survival
  • Radiotherapy
  • Spinal bone metastases

ASJC Scopus subject areas

  • Health Informatics
  • Health Policy
  • Health Information Management
  • Leadership and Management

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