Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population

Kikuko Hotta; Michihiro Nakamura; Takahiro Nakamura; Tomoaki Matsuo; Yoshio Nakata; Seika Kamohara; Nobuyuki Miyatake; Kazuaki Kotani; Ryoya Komatsu; Naoto Itoh; Ikuo Mineo; Jun Wada; Hiroaki Masuzaki; Masato Yoneda; Atsushi Nakajima; Tohru Funahashi; Shigeru Miyazaki; Katsuto Tokunaga; Manabu Kawamoto; Takato Ueno; Kazuyuki Hamaguchi; Kiyoji Tanaka; Kentaro Yamada; Toshiaki Hanafusa; Shinichi Oikawa; Hironobu Yoshimatsu; Kazuwa Nakao; Toshiie Sakata; Yuji Matsuzawa; Naoyuki Kamatani; Yusuke Nakamura

doi:10.1038/jhg.2009.106

Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population

Kikuko Hotta, Michihiro Nakamura, Takahiro Nakamura, Tomoaki Matsuo, Yoshio Nakata, Seika Kamohara, Nobuyuki Miyatake, Kazuaki Kotani, Ryoya Komatsu, Naoto Itoh, Ikuo Mineo, Jun Wada, Hiroaki Masuzaki, Masato Yoneda, Atsushi Nakajima, Tohru Funahashi, Shigeru Miyazaki, Katsuto Tokunaga, Manabu Kawamoto, Takato UenoKazuyuki Hamaguchi, Kiyoji Tanaka, Kentaro Yamada, Toshiaki Hanafusa, Shinichi Oikawa, Hironobu Yoshimatsu, Kazuwa Nakao, Toshiie Sakata, Yuji Matsuzawa, Naoyuki Kamatani, Yusuke Nakamura

Research output: Contribution to journal › Article › peer-review

85 Citations (Scopus)

Abstract

There is evidence that the obesity phenotype in the Caucasian populations is associated with variations in several genes, including neuronal growth regulator 1 (NEGR1), SEC16 homolog B (SCE16B), transmembrane protein 18 (TMEM18), ets variant 5 (ETV5), glucosamine-6-phosphate deaminase 2 (GNPDA2), prolactin (PRL), brain-derived neurotrophic factor (BDNF), mitochondrial carrier homolog 2 (MTCH2), Fas apoptotic inhibitory molecule 2 (FAIM2), SH2B adaptor protein 1 (SH2B1), v-maf musculoaponeurotic fibrosarcoma oncogene homolog (MAF), Niemann-Pick disease, type C1 (NPC1), melanocortin 4 receptor (MC4R) and potassium channel tetramerisation domain containing 15 (KCTD15). To investigate the relationship between obesity and these genes in the Japanese population, we genotyped 27 single-nucleotide polymorphisms (SNPs) in 14 genes from obese subjects (n=1129, body mass index (BMI) 30 ≥kg m^-2) and normal-weight control subjects (n=1736, BMI <25 kg m^-2). The SNP rs10913469 in SEC16B (P=0.000012) and four SNPs (rs2867125, rs6548238, rs4854344 and rs7561317) in the TMEM18 gene (P=0.00015), all of which were in almost absolute linkage disequilibrium, were significantly associated with obesity in the Japanese population. SNPs in GNPDA2, BDNF, FAIM2 and MC4R genes were marginally associated with obesity (P<0.05). Our data suggest that some SNPs identified by genome-wide association studies in the Caucasians also confer susceptibility to obesity in Japanese subjects.

Original language	English
Pages (from-to)	727-731
Number of pages	5
Journal	Journal of Human Genetics
Volume	54
Issue number	12
DOIs	https://doi.org/10.1038/jhg.2009.106
Publication status	Published - Dec 2009

Keywords

BDNF gene
FAIM2 gene
GNPDA2 gene
Japanese
MC4R gene
Obesity
SCE16B gene
TMEM18 gene

ASJC Scopus subject areas

Genetics
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/jhg.2009.106

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Hotta, K., Nakamura, M., Nakamura, T., Matsuo, T., Nakata, Y., Kamohara, S., Miyatake, N., Kotani, K., Komatsu, R., Itoh, N., Mineo, I., Wada, J., Masuzaki, H., Yoneda, M., Nakajima, A., Funahashi, T., Miyazaki, S., Tokunaga, K., Kawamoto, M., ... Nakamura, Y. (2009). Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. Journal of Human Genetics, 54(12), 727-731. https://doi.org/10.1038/jhg.2009.106

Hotta, K, Nakamura, M, Nakamura, T, Matsuo, T, Nakata, Y, Kamohara, S, Miyatake, N, Kotani, K, Komatsu, R, Itoh, N, Mineo, I, Wada, J, Masuzaki, H, Yoneda, M, Nakajima, A, Funahashi, T, Miyazaki, S, Tokunaga, K, Kawamoto, M, Ueno, T, Hamaguchi, K, Tanaka, K, Yamada, K, Hanafusa, T, Oikawa, S, Yoshimatsu, H, Nakao, K, Sakata, T, Matsuzawa, Y, Kamatani, N & Nakamura, Y 2009, 'Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population', Journal of Human Genetics, vol. 54, no. 12, pp. 727-731. https://doi.org/10.1038/jhg.2009.106

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title = "Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population",

abstract = "There is evidence that the obesity phenotype in the Caucasian populations is associated with variations in several genes, including neuronal growth regulator 1 (NEGR1), SEC16 homolog B (SCE16B), transmembrane protein 18 (TMEM18), ets variant 5 (ETV5), glucosamine-6-phosphate deaminase 2 (GNPDA2), prolactin (PRL), brain-derived neurotrophic factor (BDNF), mitochondrial carrier homolog 2 (MTCH2), Fas apoptotic inhibitory molecule 2 (FAIM2), SH2B adaptor protein 1 (SH2B1), v-maf musculoaponeurotic fibrosarcoma oncogene homolog (MAF), Niemann-Pick disease, type C1 (NPC1), melanocortin 4 receptor (MC4R) and potassium channel tetramerisation domain containing 15 (KCTD15). To investigate the relationship between obesity and these genes in the Japanese population, we genotyped 27 single-nucleotide polymorphisms (SNPs) in 14 genes from obese subjects (n=1129, body mass index (BMI) 30 ≥kg m-2) and normal-weight control subjects (n=1736, BMI <25 kg m-2). The SNP rs10913469 in SEC16B (P=0.000012) and four SNPs (rs2867125, rs6548238, rs4854344 and rs7561317) in the TMEM18 gene (P=0.00015), all of which were in almost absolute linkage disequilibrium, were significantly associated with obesity in the Japanese population. SNPs in GNPDA2, BDNF, FAIM2 and MC4R genes were marginally associated with obesity (P<0.05). Our data suggest that some SNPs identified by genome-wide association studies in the Caucasians also confer susceptibility to obesity in Japanese subjects.",

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author = "Kikuko Hotta and Michihiro Nakamura and Takahiro Nakamura and Tomoaki Matsuo and Yoshio Nakata and Seika Kamohara and Nobuyuki Miyatake and Kazuaki Kotani and Ryoya Komatsu and Naoto Itoh and Ikuo Mineo and Jun Wada and Hiroaki Masuzaki and Masato Yoneda and Atsushi Nakajima and Tohru Funahashi and Shigeru Miyazaki and Katsuto Tokunaga and Manabu Kawamoto and Takato Ueno and Kazuyuki Hamaguchi and Kiyoji Tanaka and Kentaro Yamada and Toshiaki Hanafusa and Shinichi Oikawa and Hironobu Yoshimatsu and Kazuwa Nakao and Toshiie Sakata and Yuji Matsuzawa and Naoyuki Kamatani and Yusuke Nakamura",

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doi = "10.1038/jhg.2009.106",

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T1 - Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population

AU - Hotta, Kikuko

AU - Nakamura, Michihiro

AU - Nakamura, Takahiro

AU - Matsuo, Tomoaki

AU - Nakata, Yoshio

AU - Kamohara, Seika

AU - Miyatake, Nobuyuki

AU - Kotani, Kazuaki

AU - Komatsu, Ryoya

AU - Itoh, Naoto

AU - Mineo, Ikuo

AU - Wada, Jun

AU - Masuzaki, Hiroaki

AU - Yoneda, Masato

AU - Nakajima, Atsushi

AU - Funahashi, Tohru

AU - Miyazaki, Shigeru

AU - Tokunaga, Katsuto

AU - Kawamoto, Manabu

AU - Ueno, Takato

AU - Hamaguchi, Kazuyuki

AU - Tanaka, Kiyoji

AU - Yamada, Kentaro

AU - Hanafusa, Toshiaki

AU - Oikawa, Shinichi

AU - Yoshimatsu, Hironobu

AU - Nakao, Kazuwa

AU - Sakata, Toshiie

AU - Matsuzawa, Yuji

AU - Kamatani, Naoyuki

AU - Nakamura, Yusuke

PY - 2009/12

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AB - There is evidence that the obesity phenotype in the Caucasian populations is associated with variations in several genes, including neuronal growth regulator 1 (NEGR1), SEC16 homolog B (SCE16B), transmembrane protein 18 (TMEM18), ets variant 5 (ETV5), glucosamine-6-phosphate deaminase 2 (GNPDA2), prolactin (PRL), brain-derived neurotrophic factor (BDNF), mitochondrial carrier homolog 2 (MTCH2), Fas apoptotic inhibitory molecule 2 (FAIM2), SH2B adaptor protein 1 (SH2B1), v-maf musculoaponeurotic fibrosarcoma oncogene homolog (MAF), Niemann-Pick disease, type C1 (NPC1), melanocortin 4 receptor (MC4R) and potassium channel tetramerisation domain containing 15 (KCTD15). To investigate the relationship between obesity and these genes in the Japanese population, we genotyped 27 single-nucleotide polymorphisms (SNPs) in 14 genes from obese subjects (n=1129, body mass index (BMI) 30 ≥kg m-2) and normal-weight control subjects (n=1736, BMI <25 kg m-2). The SNP rs10913469 in SEC16B (P=0.000012) and four SNPs (rs2867125, rs6548238, rs4854344 and rs7561317) in the TMEM18 gene (P=0.00015), all of which were in almost absolute linkage disequilibrium, were significantly associated with obesity in the Japanese population. SNPs in GNPDA2, BDNF, FAIM2 and MC4R genes were marginally associated with obesity (P<0.05). Our data suggest that some SNPs identified by genome-wide association studies in the Caucasians also confer susceptibility to obesity in Japanese subjects.

KW - BDNF gene

KW - FAIM2 gene

KW - GNPDA2 gene

KW - Japanese

KW - MC4R gene

KW - Obesity

KW - SCE16B gene

KW - TMEM18 gene

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Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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