Association between macrocytosis and metachronous squamous cell carcinoma of the esophagus after endoscopic resection in men with early esophageal squamous cell carcinoma

Chikatoshi Katada, Tetsuji Yokoyama, Tomonori Yano, Ichiro Oda, Yuichi Shimizu, Hisashi Doyama, Tomoyuki Koike, Kohei Takizawa, Motohiro Hirao, Hiroyuki Okada, Takako Yoshii, Yutaro Kubota, Takenori Yamanouchi, Takashi Tsuda, Tai Omori, Nozomu Kobayashi, Haruhisa Suzuki, Satoshi Tanabe, Keisuke Hori, Norisuke NakayamaHirofumi Kawakubo, Naomi Kakushima, Yasumasa Matsuo, Hideki Ishikawa, Akira Yokoyama, Manabu Muto

Research output: Contribution to journalArticle

Abstract

Background: Macrocytosis is associated with an increased risk of squamous cell carcinoma (SCC) arising in the esophagus in men. The aim of this study was to evaluate the association between macrocytosis and metachronous SCC of the esophagus after endoscopic resection (ER) of early esophageal SCC in men. Methods: The study group comprised 278 men with early esophageal SCC after ER. The main study variables were as follows: (1) cumulative incidence and total number of metachronous SCC of the esophagus according to the presence or absence of macrocytosis (mean corpuscular volume ≥ 106 fl) and (2) predictors of metachronous SCC of the esophagus as assessed with a multivariate Cox proportional-hazards model. Results: The median follow-up was 50.3 months. Macrocytosis was associated with a higher 2-year cumulative incidence of metachronous SCC of the esophagus (without macrocytosis vs. with macrocytosis: 11.4% vs. 38.1%, p = 0.002). Macrocytosis was also associated with a higher total number of metachronous SCC of the esophagus per 100 person-years (without macrocytosis vs. with macrocytosis: 7.7 vs. 31.5 per 100 person-years, p < 0.0001). In addition, macrocytosis was a significant predictor of metachronous SCC of the esophagus on multivariate Cox proportional-hazards analysis (relative risk 2.23). Conclusion: Macrocytosis is a useful predictor of the risk of metachronous SCC of the esophagus after ER of early esophageal SCC in men.

Original languageEnglish
JournalEsophagus
DOIs
Publication statusAccepted/In press - Jan 1 2019

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Esophagus
Squamous Cell Carcinoma
Erythrocyte Indices
Esophageal Squamous Cell Carcinoma
Incidence
Proportional Hazards Models

Keywords

  • Endoscopic resection
  • Esophageal cancer
  • Macrocytosis
  • Mean corpuscular volume
  • Metachronous cancer

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Association between macrocytosis and metachronous squamous cell carcinoma of the esophagus after endoscopic resection in men with early esophageal squamous cell carcinoma. / Katada, Chikatoshi; Yokoyama, Tetsuji; Yano, Tomonori; Oda, Ichiro; Shimizu, Yuichi; Doyama, Hisashi; Koike, Tomoyuki; Takizawa, Kohei; Hirao, Motohiro; Okada, Hiroyuki; Yoshii, Takako; Kubota, Yutaro; Yamanouchi, Takenori; Tsuda, Takashi; Omori, Tai; Kobayashi, Nozomu; Suzuki, Haruhisa; Tanabe, Satoshi; Hori, Keisuke; Nakayama, Norisuke; Kawakubo, Hirofumi; Kakushima, Naomi; Matsuo, Yasumasa; Ishikawa, Hideki; Yokoyama, Akira; Muto, Manabu.

In: Esophagus, 01.01.2019.

Research output: Contribution to journalArticle

Katada, C, Yokoyama, T, Yano, T, Oda, I, Shimizu, Y, Doyama, H, Koike, T, Takizawa, K, Hirao, M, Okada, H, Yoshii, T, Kubota, Y, Yamanouchi, T, Tsuda, T, Omori, T, Kobayashi, N, Suzuki, H, Tanabe, S, Hori, K, Nakayama, N, Kawakubo, H, Kakushima, N, Matsuo, Y, Ishikawa, H, Yokoyama, A & Muto, M 2019, 'Association between macrocytosis and metachronous squamous cell carcinoma of the esophagus after endoscopic resection in men with early esophageal squamous cell carcinoma', Esophagus. https://doi.org/10.1007/s10388-019-00685-w
Katada, Chikatoshi ; Yokoyama, Tetsuji ; Yano, Tomonori ; Oda, Ichiro ; Shimizu, Yuichi ; Doyama, Hisashi ; Koike, Tomoyuki ; Takizawa, Kohei ; Hirao, Motohiro ; Okada, Hiroyuki ; Yoshii, Takako ; Kubota, Yutaro ; Yamanouchi, Takenori ; Tsuda, Takashi ; Omori, Tai ; Kobayashi, Nozomu ; Suzuki, Haruhisa ; Tanabe, Satoshi ; Hori, Keisuke ; Nakayama, Norisuke ; Kawakubo, Hirofumi ; Kakushima, Naomi ; Matsuo, Yasumasa ; Ishikawa, Hideki ; Yokoyama, Akira ; Muto, Manabu. / Association between macrocytosis and metachronous squamous cell carcinoma of the esophagus after endoscopic resection in men with early esophageal squamous cell carcinoma. In: Esophagus. 2019.
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abstract = "Background: Macrocytosis is associated with an increased risk of squamous cell carcinoma (SCC) arising in the esophagus in men. The aim of this study was to evaluate the association between macrocytosis and metachronous SCC of the esophagus after endoscopic resection (ER) of early esophageal SCC in men. Methods: The study group comprised 278 men with early esophageal SCC after ER. The main study variables were as follows: (1) cumulative incidence and total number of metachronous SCC of the esophagus according to the presence or absence of macrocytosis (mean corpuscular volume ≥ 106 fl) and (2) predictors of metachronous SCC of the esophagus as assessed with a multivariate Cox proportional-hazards model. Results: The median follow-up was 50.3 months. Macrocytosis was associated with a higher 2-year cumulative incidence of metachronous SCC of the esophagus (without macrocytosis vs. with macrocytosis: 11.4{\%} vs. 38.1{\%}, p = 0.002). Macrocytosis was also associated with a higher total number of metachronous SCC of the esophagus per 100 person-years (without macrocytosis vs. with macrocytosis: 7.7 vs. 31.5 per 100 person-years, p < 0.0001). In addition, macrocytosis was a significant predictor of metachronous SCC of the esophagus on multivariate Cox proportional-hazards analysis (relative risk 2.23). Conclusion: Macrocytosis is a useful predictor of the risk of metachronous SCC of the esophagus after ER of early esophageal SCC in men.",
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author = "Chikatoshi Katada and Tetsuji Yokoyama and Tomonori Yano and Ichiro Oda and Yuichi Shimizu and Hisashi Doyama and Tomoyuki Koike and Kohei Takizawa and Motohiro Hirao and Hiroyuki Okada and Takako Yoshii and Yutaro Kubota and Takenori Yamanouchi and Takashi Tsuda and Tai Omori and Nozomu Kobayashi and Haruhisa Suzuki and Satoshi Tanabe and Keisuke Hori and Norisuke Nakayama and Hirofumi Kawakubo and Naomi Kakushima and Yasumasa Matsuo and Hideki Ishikawa and Akira Yokoyama and Manabu Muto",
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TY - JOUR

T1 - Association between macrocytosis and metachronous squamous cell carcinoma of the esophagus after endoscopic resection in men with early esophageal squamous cell carcinoma

AU - Katada, Chikatoshi

AU - Yokoyama, Tetsuji

AU - Yano, Tomonori

AU - Oda, Ichiro

AU - Shimizu, Yuichi

AU - Doyama, Hisashi

AU - Koike, Tomoyuki

AU - Takizawa, Kohei

AU - Hirao, Motohiro

AU - Okada, Hiroyuki

AU - Yoshii, Takako

AU - Kubota, Yutaro

AU - Yamanouchi, Takenori

AU - Tsuda, Takashi

AU - Omori, Tai

AU - Kobayashi, Nozomu

AU - Suzuki, Haruhisa

AU - Tanabe, Satoshi

AU - Hori, Keisuke

AU - Nakayama, Norisuke

AU - Kawakubo, Hirofumi

AU - Kakushima, Naomi

AU - Matsuo, Yasumasa

AU - Ishikawa, Hideki

AU - Yokoyama, Akira

AU - Muto, Manabu

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Macrocytosis is associated with an increased risk of squamous cell carcinoma (SCC) arising in the esophagus in men. The aim of this study was to evaluate the association between macrocytosis and metachronous SCC of the esophagus after endoscopic resection (ER) of early esophageal SCC in men. Methods: The study group comprised 278 men with early esophageal SCC after ER. The main study variables were as follows: (1) cumulative incidence and total number of metachronous SCC of the esophagus according to the presence or absence of macrocytosis (mean corpuscular volume ≥ 106 fl) and (2) predictors of metachronous SCC of the esophagus as assessed with a multivariate Cox proportional-hazards model. Results: The median follow-up was 50.3 months. Macrocytosis was associated with a higher 2-year cumulative incidence of metachronous SCC of the esophagus (without macrocytosis vs. with macrocytosis: 11.4% vs. 38.1%, p = 0.002). Macrocytosis was also associated with a higher total number of metachronous SCC of the esophagus per 100 person-years (without macrocytosis vs. with macrocytosis: 7.7 vs. 31.5 per 100 person-years, p < 0.0001). In addition, macrocytosis was a significant predictor of metachronous SCC of the esophagus on multivariate Cox proportional-hazards analysis (relative risk 2.23). Conclusion: Macrocytosis is a useful predictor of the risk of metachronous SCC of the esophagus after ER of early esophageal SCC in men.

AB - Background: Macrocytosis is associated with an increased risk of squamous cell carcinoma (SCC) arising in the esophagus in men. The aim of this study was to evaluate the association between macrocytosis and metachronous SCC of the esophagus after endoscopic resection (ER) of early esophageal SCC in men. Methods: The study group comprised 278 men with early esophageal SCC after ER. The main study variables were as follows: (1) cumulative incidence and total number of metachronous SCC of the esophagus according to the presence or absence of macrocytosis (mean corpuscular volume ≥ 106 fl) and (2) predictors of metachronous SCC of the esophagus as assessed with a multivariate Cox proportional-hazards model. Results: The median follow-up was 50.3 months. Macrocytosis was associated with a higher 2-year cumulative incidence of metachronous SCC of the esophagus (without macrocytosis vs. with macrocytosis: 11.4% vs. 38.1%, p = 0.002). Macrocytosis was also associated with a higher total number of metachronous SCC of the esophagus per 100 person-years (without macrocytosis vs. with macrocytosis: 7.7 vs. 31.5 per 100 person-years, p < 0.0001). In addition, macrocytosis was a significant predictor of metachronous SCC of the esophagus on multivariate Cox proportional-hazards analysis (relative risk 2.23). Conclusion: Macrocytosis is a useful predictor of the risk of metachronous SCC of the esophagus after ER of early esophageal SCC in men.

KW - Endoscopic resection

KW - Esophageal cancer

KW - Macrocytosis

KW - Mean corpuscular volume

KW - Metachronous cancer

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U2 - 10.1007/s10388-019-00685-w

DO - 10.1007/s10388-019-00685-w

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JO - Esophagus

JF - Esophagus

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