TY - JOUR
T1 - Association between J-point elevation and death from coronary artery disease
T2 - 15-year follow-up of the NIPPON DATA90
AU - Hisamatsu, Takashi
AU - Ohkubo, Takayoshi
AU - Miura, Katsuyuki
AU - Yamamoto, Takashi
AU - Fujiyoshi, Akira
AU - Miyagawa, Naoko
AU - Kadota, Aya
AU - Takashima, Naoyuki
AU - Nagasawa, Shin ya
AU - Kita, Yoshikuni
AU - Murakami, Yoshitaka
AU - Okayama, Akira
AU - Horie, Minoru
AU - Okamura, Tomonori
AU - Ueshima, Hirotsugu
PY - 2013
Y1 - 2013
N2 - Background: An early repolarization pattern, characterized by an elevation of the QRS-ST junction (J-point) on 12-lead electrocardiography (ECG) is associated with cardiac and sudden death. However, little is known about the prognostic significance of J-point elevation for various disease-specific cardiovascular outcomes, including coronary artery disease (CAD). Methods and Results: To investigate the association between the presence of J-point elevation ≥0.1 mV and various disease-specific cardiovascular outcomes, we conducted a 15-year prospective study in a representative general Japanese population of 7,630 individuals (41% men, mean age 52.4 years) who participated in the National Survey of Circulatory Disorders. Cox models were used to estimate the hazard ratios (HRs) adjusted for possible confounding factors. J-point elevation was present in 264 individuals (3.5%) and was associated with an increased risk of cardiac death (adjusted HR, 2.54; 95% confidence interval [CI] 1.40-4.58; P=0.002) and death from CAD (adjusted HR, 4.66; 95% CI 2.30-9.46; P<0.001). In a subgroup analysis by age, the association between J-point elevation and cardiovascular outcomes was more remarkable in middle-aged (<60 years) than in older individuals (≥60 years) (all P for interaction <0.05). Conclusions: J-point elevation on standard 12-lead ECG was an independent predictor of cardiac death and death from CAD in a representative sample of the general Japanese population, particularly among the middle-aged.
AB - Background: An early repolarization pattern, characterized by an elevation of the QRS-ST junction (J-point) on 12-lead electrocardiography (ECG) is associated with cardiac and sudden death. However, little is known about the prognostic significance of J-point elevation for various disease-specific cardiovascular outcomes, including coronary artery disease (CAD). Methods and Results: To investigate the association between the presence of J-point elevation ≥0.1 mV and various disease-specific cardiovascular outcomes, we conducted a 15-year prospective study in a representative general Japanese population of 7,630 individuals (41% men, mean age 52.4 years) who participated in the National Survey of Circulatory Disorders. Cox models were used to estimate the hazard ratios (HRs) adjusted for possible confounding factors. J-point elevation was present in 264 individuals (3.5%) and was associated with an increased risk of cardiac death (adjusted HR, 2.54; 95% confidence interval [CI] 1.40-4.58; P=0.002) and death from CAD (adjusted HR, 4.66; 95% CI 2.30-9.46; P<0.001). In a subgroup analysis by age, the association between J-point elevation and cardiovascular outcomes was more remarkable in middle-aged (<60 years) than in older individuals (≥60 years) (all P for interaction <0.05). Conclusions: J-point elevation on standard 12-lead ECG was an independent predictor of cardiac death and death from CAD in a representative sample of the general Japanese population, particularly among the middle-aged.
KW - Cardiovascular diseases
KW - Coronary artery disease
KW - Electrocardiography
KW - Epidemiology
KW - J-point
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U2 - 10.1253/circj.CJ-12-1273
DO - 10.1253/circj.CJ-12-1273
M3 - Article
C2 - 23358431
AN - SCOPUS:84876779226
SN - 1346-9843
VL - 77
SP - 1260
EP - 1266
JO - Circulation Journal
JF - Circulation Journal
IS - 5
ER -
