Association between cytokine removal by polymyxin B hemoperfusion and improved pulmonary oxygenation in patients with acute exacerbation of idiopathic pulmonary fibrosis

Keiji Oishi, Yuka Mimura-Kimura, Taku Miyasho, Keisuke Aoe, Yoshiko Ogata, Hideki Katayama, Yoriyuki Murata, Hiroshi Ueoka, Tsuneo Matsumoto, Yusuke Mimura

Research output: Contribution to journalArticle

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Abstract

Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is characterized by severe worsening dyspnea of unknown etiology and high mortality without effective treatment. Recently, direct hemoperfusion with polymyxin B (PMX)-immobilized fiber cartridge (PMX-DHP) has been reported to improve pulmonary oxygenation and survival in patients with AE-IPF although its mechanism of action remains unknown. To gain insights into the pathobiology of AE-IPF through the beneficial effects of PMX-DHP, we analyzed the profile of cytokines adsorbed onto PMX-fibers used in 9 AE-IPF patients. In addition, the sera of these AE-IPF patients collected immediately before and after PMX-DHP, 9 stable IPF patients and 8 healthy individuals were also analyzed. The serum levels of cytokines including IL-9, IL-12, IL-17, PDGF and VEGF were significantly decreased immediately after PMX-DHP (P

Original languageEnglish
Pages (from-to)84-89
Number of pages6
JournalCytokine
Volume61
Issue number1
DOIs
Publication statusPublished - Jan 2013
Externally publishedYes

Fingerprint

Hemoperfusion
Polymyxin B
Idiopathic Pulmonary Fibrosis
Oxygenation
Cytokines
Lung
Interleukin-9
Myelinated Nerve Fibers
Interleukin-17
Fibers
Interleukin-12
Serum
Dyspnea
Vascular Endothelial Growth Factor A
Survival
Mortality

Keywords

  • Heparin
  • Hypoxemia
  • Idiopathic interstitial pneumonia
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology
  • Biochemistry
  • Molecular Biology

Cite this

Association between cytokine removal by polymyxin B hemoperfusion and improved pulmonary oxygenation in patients with acute exacerbation of idiopathic pulmonary fibrosis. / Oishi, Keiji; Mimura-Kimura, Yuka; Miyasho, Taku; Aoe, Keisuke; Ogata, Yoshiko; Katayama, Hideki; Murata, Yoriyuki; Ueoka, Hiroshi; Matsumoto, Tsuneo; Mimura, Yusuke.

In: Cytokine, Vol. 61, No. 1, 01.2013, p. 84-89.

Research output: Contribution to journalArticle

Oishi, Keiji ; Mimura-Kimura, Yuka ; Miyasho, Taku ; Aoe, Keisuke ; Ogata, Yoshiko ; Katayama, Hideki ; Murata, Yoriyuki ; Ueoka, Hiroshi ; Matsumoto, Tsuneo ; Mimura, Yusuke. / Association between cytokine removal by polymyxin B hemoperfusion and improved pulmonary oxygenation in patients with acute exacerbation of idiopathic pulmonary fibrosis. In: Cytokine. 2013 ; Vol. 61, No. 1. pp. 84-89.
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