Abstract
Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is characterized by severe worsening dyspnea of unknown etiology and high mortality without effective treatment. Recently, direct hemoperfusion with polymyxin B (PMX)-immobilized fiber cartridge (PMX-DHP) has been reported to improve pulmonary oxygenation and survival in patients with AE-IPF although its mechanism of action remains unknown. To gain insights into the pathobiology of AE-IPF through the beneficial effects of PMX-DHP, we analyzed the profile of cytokines adsorbed onto PMX-fibers used in 9 AE-IPF patients. In addition, the sera of these AE-IPF patients collected immediately before and after PMX-DHP, 9 stable IPF patients and 8 healthy individuals were also analyzed. The serum levels of cytokines including IL-9, IL-12, IL-17, PDGF and VEGF were significantly decreased immediately after PMX-DHP (P
| Original language | English |
|---|---|
| Pages (from-to) | 84-89 |
| Number of pages | 6 |
| Journal | Cytokine |
| Volume | 61 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2013 |
| Externally published | Yes |
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Keywords
- Heparin
- Hypoxemia
- Idiopathic interstitial pneumonia
- Vascular endothelial growth factor
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Hematology
- Biochemistry
- Molecular Biology
Cite this
Association between cytokine removal by polymyxin B hemoperfusion and improved pulmonary oxygenation in patients with acute exacerbation of idiopathic pulmonary fibrosis. / Oishi, Keiji; Mimura-Kimura, Yuka; Miyasho, Taku; Aoe, Keisuke; Ogata, Yoshiko; Katayama, Hideki; Murata, Yoriyuki; Ueoka, Hiroshi; Matsumoto, Tsuneo; Mimura, Yusuke.
In: Cytokine, Vol. 61, No. 1, 01.2013, p. 84-89.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between cytokine removal by polymyxin B hemoperfusion and improved pulmonary oxygenation in patients with acute exacerbation of idiopathic pulmonary fibrosis
AU - Oishi, Keiji
AU - Mimura-Kimura, Yuka
AU - Miyasho, Taku
AU - Aoe, Keisuke
AU - Ogata, Yoshiko
AU - Katayama, Hideki
AU - Murata, Yoriyuki
AU - Ueoka, Hiroshi
AU - Matsumoto, Tsuneo
AU - Mimura, Yusuke
PY - 2013/1
Y1 - 2013/1
N2 - Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is characterized by severe worsening dyspnea of unknown etiology and high mortality without effective treatment. Recently, direct hemoperfusion with polymyxin B (PMX)-immobilized fiber cartridge (PMX-DHP) has been reported to improve pulmonary oxygenation and survival in patients with AE-IPF although its mechanism of action remains unknown. To gain insights into the pathobiology of AE-IPF through the beneficial effects of PMX-DHP, we analyzed the profile of cytokines adsorbed onto PMX-fibers used in 9 AE-IPF patients. In addition, the sera of these AE-IPF patients collected immediately before and after PMX-DHP, 9 stable IPF patients and 8 healthy individuals were also analyzed. The serum levels of cytokines including IL-9, IL-12, IL-17, PDGF and VEGF were significantly decreased immediately after PMX-DHP (P
AB - Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is characterized by severe worsening dyspnea of unknown etiology and high mortality without effective treatment. Recently, direct hemoperfusion with polymyxin B (PMX)-immobilized fiber cartridge (PMX-DHP) has been reported to improve pulmonary oxygenation and survival in patients with AE-IPF although its mechanism of action remains unknown. To gain insights into the pathobiology of AE-IPF through the beneficial effects of PMX-DHP, we analyzed the profile of cytokines adsorbed onto PMX-fibers used in 9 AE-IPF patients. In addition, the sera of these AE-IPF patients collected immediately before and after PMX-DHP, 9 stable IPF patients and 8 healthy individuals were also analyzed. The serum levels of cytokines including IL-9, IL-12, IL-17, PDGF and VEGF were significantly decreased immediately after PMX-DHP (P
KW - Heparin
KW - Hypoxemia
KW - Idiopathic interstitial pneumonia
KW - Vascular endothelial growth factor
UR - http://www.scopus.com/inward/record.url?scp=84869874297&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84869874297&partnerID=8YFLogxK
U2 - 10.1016/j.cyto.2012.08.032
DO - 10.1016/j.cyto.2012.08.032
M3 - Article
VL - 61
SP - 84
EP - 89
JO - Cytokine
JF - Cytokine
SN - 1043-4666
IS - 1
ER -