Association between coronary artery calcification and left ventricular diastolic dysfunction in elderly people

Kazuhiro Osawa, Toru Miyoshi, Hiroki Oe, Shuhei Sato, Kazufumi Nakamura, Kunihisa Kohno, Hiroshi Morita, Susumu Kanazawa, Hiroshi Itoh

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Coronary artery calcification (CAC) is associated with the incidence of congestive heart failure. We evaluated the association between CAC and left ventricular diastolic dysfunction (LVDD) in elderly patients without coronary artery disease. Coronary computed tomography was performed in 1,021 consecutive patients >55 years of age who were suspected of having coronary artery disease. A total of 530 patients (age, 70 ± 8 years; 56 % men) with a LV ejection fraction >50 % and without obstructive coronary artery disease and a history of coronary artery disease were included in the analysis. LVDD was defined according to a standard algorithm by echocardiography (septal e′ 2). A total of 224 of 530 patients had LVDD. CAC scores in patients with LVDD were higher than those in patients without LVDD (p <0.01). The prevalence of LVDD in patients with CAC scores ≥400 was greater than that in patients with CAC scores of 0–9 (58 vs. 34 %, p <0.01). After adjustment for confounding factors, the CAC score was associated with LVDD, with an odds ratio of 1.96 (95 % confidence interval: 1.11–3.43, p = 0.02) for a CAC score ≥400 compared with a CAC score of 0–9. A CAC score ≥400 was associated with LVDD in elderly patients without CAD in this population. Further prospective studies are needed to evaluate the clinical relevance of CAC as a risk of heart failure with preserved ejection fraction.

Original languageEnglish
JournalHeart and Vessels
DOIs
Publication statusAccepted/In press - Feb 12 2015

Fingerprint

Left Ventricular Dysfunction
Coronary Vessels
Coronary Artery Disease
Heart Failure
Echocardiography
Odds Ratio
Tomography
Prospective Studies
Confidence Intervals
Incidence

Keywords

  • Computed tomography
  • Coronary artery calcification
  • Heart failure
  • Left ventricular diastolic dysfunction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{d8f7583ea4e14baaa238fce3834251be,
title = "Association between coronary artery calcification and left ventricular diastolic dysfunction in elderly people",
abstract = "Coronary artery calcification (CAC) is associated with the incidence of congestive heart failure. We evaluated the association between CAC and left ventricular diastolic dysfunction (LVDD) in elderly patients without coronary artery disease. Coronary computed tomography was performed in 1,021 consecutive patients >55 years of age who were suspected of having coronary artery disease. A total of 530 patients (age, 70 ± 8 years; 56 {\%} men) with a LV ejection fraction >50 {\%} and without obstructive coronary artery disease and a history of coronary artery disease were included in the analysis. LVDD was defined according to a standard algorithm by echocardiography (septal e′ 2). A total of 224 of 530 patients had LVDD. CAC scores in patients with LVDD were higher than those in patients without LVDD (p <0.01). The prevalence of LVDD in patients with CAC scores ≥400 was greater than that in patients with CAC scores of 0–9 (58 vs. 34 {\%}, p <0.01). After adjustment for confounding factors, the CAC score was associated with LVDD, with an odds ratio of 1.96 (95 {\%} confidence interval: 1.11–3.43, p = 0.02) for a CAC score ≥400 compared with a CAC score of 0–9. A CAC score ≥400 was associated with LVDD in elderly patients without CAD in this population. Further prospective studies are needed to evaluate the clinical relevance of CAC as a risk of heart failure with preserved ejection fraction.",
keywords = "Computed tomography, Coronary artery calcification, Heart failure, Left ventricular diastolic dysfunction",
author = "Kazuhiro Osawa and Toru Miyoshi and Hiroki Oe and Shuhei Sato and Kazufumi Nakamura and Kunihisa Kohno and Hiroshi Morita and Susumu Kanazawa and Hiroshi Itoh",
year = "2015",
month = "2",
day = "12",
doi = "10.1007/s00380-015-0645-5",
language = "English",
journal = "Heart and Vessels",
issn = "0910-8327",
publisher = "Springer Japan",

}

TY - JOUR

T1 - Association between coronary artery calcification and left ventricular diastolic dysfunction in elderly people

AU - Osawa, Kazuhiro

AU - Miyoshi, Toru

AU - Oe, Hiroki

AU - Sato, Shuhei

AU - Nakamura, Kazufumi

AU - Kohno, Kunihisa

AU - Morita, Hiroshi

AU - Kanazawa, Susumu

AU - Itoh, Hiroshi

PY - 2015/2/12

Y1 - 2015/2/12

N2 - Coronary artery calcification (CAC) is associated with the incidence of congestive heart failure. We evaluated the association between CAC and left ventricular diastolic dysfunction (LVDD) in elderly patients without coronary artery disease. Coronary computed tomography was performed in 1,021 consecutive patients >55 years of age who were suspected of having coronary artery disease. A total of 530 patients (age, 70 ± 8 years; 56 % men) with a LV ejection fraction >50 % and without obstructive coronary artery disease and a history of coronary artery disease were included in the analysis. LVDD was defined according to a standard algorithm by echocardiography (septal e′ 2). A total of 224 of 530 patients had LVDD. CAC scores in patients with LVDD were higher than those in patients without LVDD (p <0.01). The prevalence of LVDD in patients with CAC scores ≥400 was greater than that in patients with CAC scores of 0–9 (58 vs. 34 %, p <0.01). After adjustment for confounding factors, the CAC score was associated with LVDD, with an odds ratio of 1.96 (95 % confidence interval: 1.11–3.43, p = 0.02) for a CAC score ≥400 compared with a CAC score of 0–9. A CAC score ≥400 was associated with LVDD in elderly patients without CAD in this population. Further prospective studies are needed to evaluate the clinical relevance of CAC as a risk of heart failure with preserved ejection fraction.

AB - Coronary artery calcification (CAC) is associated with the incidence of congestive heart failure. We evaluated the association between CAC and left ventricular diastolic dysfunction (LVDD) in elderly patients without coronary artery disease. Coronary computed tomography was performed in 1,021 consecutive patients >55 years of age who were suspected of having coronary artery disease. A total of 530 patients (age, 70 ± 8 years; 56 % men) with a LV ejection fraction >50 % and without obstructive coronary artery disease and a history of coronary artery disease were included in the analysis. LVDD was defined according to a standard algorithm by echocardiography (septal e′ 2). A total of 224 of 530 patients had LVDD. CAC scores in patients with LVDD were higher than those in patients without LVDD (p <0.01). The prevalence of LVDD in patients with CAC scores ≥400 was greater than that in patients with CAC scores of 0–9 (58 vs. 34 %, p <0.01). After adjustment for confounding factors, the CAC score was associated with LVDD, with an odds ratio of 1.96 (95 % confidence interval: 1.11–3.43, p = 0.02) for a CAC score ≥400 compared with a CAC score of 0–9. A CAC score ≥400 was associated with LVDD in elderly patients without CAD in this population. Further prospective studies are needed to evaluate the clinical relevance of CAC as a risk of heart failure with preserved ejection fraction.

KW - Computed tomography

KW - Coronary artery calcification

KW - Heart failure

KW - Left ventricular diastolic dysfunction

UR - http://www.scopus.com/inward/record.url?scp=84922700078&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922700078&partnerID=8YFLogxK

U2 - 10.1007/s00380-015-0645-5

DO - 10.1007/s00380-015-0645-5

M3 - Article

C2 - 25673497

AN - SCOPUS:84922700078

JO - Heart and Vessels

JF - Heart and Vessels

SN - 0910-8327

ER -