Abstract
Vibrio vulnificus, a ubiquitous microorganism in aquatic environments, causes serious septicemia to the immunocompromised host. In addition to protoheme, this species can utilize FeTCPP [ferric tetrakis (4-carboxyphenyl) porphine] as an iron source. In the present study, heme c bound covalently to the protein in cytochrome c, as well as the Fe-TCPP complex formed with a nanopeptide with a high affinity, was found to be useful iron sources for V. vulnificus. This bacterium was also revealed to use Zn-TCPP as a single zinc source. However, other metalloporphyrins such as Mn-TCPP and Pt-TCPP delayed the bacterial growth in the broth containing Fe-TCPP, suggesting interference in the iron assimilation. These results indicate that V. vulnificus may acquire metal ions from both free and peptide-bound metalloporphyrins.
| Original language | English |
|---|---|
| Pages (from-to) | 1-6 |
| Number of pages | 6 |
| Journal | Biocontrol Science |
| Volume | 15 |
| Issue number | 1 |
| Publication status | Published - 2010 |
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Keywords
- Heme
- Iron source
- Metalloporphyrin
- Vibrio vulnificus
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology
- Public Health, Environmental and Occupational Health
Cite this
Assimilation of metal ions bound to porphyrins or porphyrin-peptides by Vibrio vulnificus, a human pathogen inhabiting estuarine and marine environments. / Miyoshi, Shin-ichi; Sasaki, Tomoko; Kaku, Nahoko; Inoue, Takaharu; Uozumi, Natsuki; Maehara, Yoko; Nakao, Hiroshi.
In: Biocontrol Science, Vol. 15, No. 1, 2010, p. 1-6.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Assimilation of metal ions bound to porphyrins or porphyrin-peptides by Vibrio vulnificus, a human pathogen inhabiting estuarine and marine environments
AU - Miyoshi, Shin-ichi
AU - Sasaki, Tomoko
AU - Kaku, Nahoko
AU - Inoue, Takaharu
AU - Uozumi, Natsuki
AU - Maehara, Yoko
AU - Nakao, Hiroshi
PY - 2010
Y1 - 2010
N2 - Vibrio vulnificus, a ubiquitous microorganism in aquatic environments, causes serious septicemia to the immunocompromised host. In addition to protoheme, this species can utilize FeTCPP [ferric tetrakis (4-carboxyphenyl) porphine] as an iron source. In the present study, heme c bound covalently to the protein in cytochrome c, as well as the Fe-TCPP complex formed with a nanopeptide with a high affinity, was found to be useful iron sources for V. vulnificus. This bacterium was also revealed to use Zn-TCPP as a single zinc source. However, other metalloporphyrins such as Mn-TCPP and Pt-TCPP delayed the bacterial growth in the broth containing Fe-TCPP, suggesting interference in the iron assimilation. These results indicate that V. vulnificus may acquire metal ions from both free and peptide-bound metalloporphyrins.
AB - Vibrio vulnificus, a ubiquitous microorganism in aquatic environments, causes serious septicemia to the immunocompromised host. In addition to protoheme, this species can utilize FeTCPP [ferric tetrakis (4-carboxyphenyl) porphine] as an iron source. In the present study, heme c bound covalently to the protein in cytochrome c, as well as the Fe-TCPP complex formed with a nanopeptide with a high affinity, was found to be useful iron sources for V. vulnificus. This bacterium was also revealed to use Zn-TCPP as a single zinc source. However, other metalloporphyrins such as Mn-TCPP and Pt-TCPP delayed the bacterial growth in the broth containing Fe-TCPP, suggesting interference in the iron assimilation. These results indicate that V. vulnificus may acquire metal ions from both free and peptide-bound metalloporphyrins.
KW - Heme
KW - Iron source
KW - Metalloporphyrin
KW - Vibrio vulnificus
UR - http://www.scopus.com/inward/record.url?scp=77950499322&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950499322&partnerID=8YFLogxK
M3 - Article
VL - 15
SP - 1
EP - 6
JO - Biocontrol Science
JF - Biocontrol Science
SN - 1342-4815
IS - 1
ER -