Assessment of tubular function in neonates using urinary β2-microglobulin

Hirokazu Tsukahara, Masahiro Yoshimoto, Masakazu Saito, Tadahiko Sakaguchi, Izuru Mitsuyoshi, Syuhei Hayashi, Katsuji Nakamura, Kiyoshi Kikuchi, Masakatsu Sudo

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19 Citations (Scopus)

Abstract

Renal proximal tubular function was assessed in neonates by measuring urinary β2-microglobulin (β2M) concentrations on days 1, 4, 7, 14 and 28. Values were elevated in stable preterm low-birthweight (LBW) neonates but not in stable term LBW neonates, suggesting that proximal tubular maturation is related to gestational age rather than birthweight. The urinary β2M was significantly increased on day 1 in neonates with the meconium aspiration syndrome but was not significantly different from normal subsequently. This indicated that although the proximal tubular cells may be susceptible to perinatal hypoxia, they maintain a remarkable capacity to recover in a relatively short period. Neonates with transient tachypnoea of the newborn had normal urinary levels of β2M indicating their renal tubular function was not impaired.

Original languageEnglish
Pages (from-to)512-514
Number of pages3
JournalPediatric Nephrology
Volume4
Issue number5
DOIs
Publication statusPublished - Sep 1990

Keywords

  • Meconium aspiration syndrome
  • Preterm neonates
  • Renal proximal tubular function
  • Transient tachypnoea of newborn
  • Urinary β-microglobulin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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    Tsukahara, H., Yoshimoto, M., Saito, M., Sakaguchi, T., Mitsuyoshi, I., Hayashi, S., Nakamura, K., Kikuchi, K., & Sudo, M. (1990). Assessment of tubular function in neonates using urinary β2-microglobulin. Pediatric Nephrology, 4(5), 512-514. https://doi.org/10.1007/BF00869835