Assessment of the plasma/serum IgG test to screen for periodontitis

C. Kudo, K. Naruishi, H. Maeda, Y. Abiko, T. Hino, M. Iwata, C. Mitsuhashi, S. Murakami, T. Nagasawa, T. Nagata, S. Yoneda, Y. Nomura, T. Noguchi, Y. Numabe, Y. Ogata, T. Sato, H. Shimauchi, K. Yamazaki, A. Yoshimura, S. Takashiba

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)


Chronic periodontitis is a silent infectious disease prevalent worldwide and affects lifestyle-related diseases. Therefore, efficient screening of patients is essential for general health. This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens. Oral examination was performed, and IgG titers against periodontal pathogens were measured by ELISA in 1,387 individuals. The cut-off value of the IgG titer was determined in receiver operating characteristic curve analysis, and changes in periodontal clinical parameters and IgG titers by periodontal treatment were evaluated. The relationships between IgG titers and severity of periodontitis were analyzed. The best cut-off value of IgG titer against Porphyromonas gingivalis for screening periodontitis was 1.682. Both clinical parameters and IgG titers decreased significantly under periodontal treatment. IgG titers of periodontitis patients were significantly higher than those of healthy controls, especially in those with sites of probing pocket depth over 4 mm. Multiplied cut-off values were useful to select patients with severe periodontitis. A blood IgG antibody titer test for Porphyromonas gingivalis is useful to screen hitherto chronic periodontitis patients ( number NCT01658475).

Original languageEnglish
Pages (from-to)1190-1195
Number of pages6
JournalJournal of dental research
Issue number12
Publication statusPublished - Dec 2012


  • Porphyromonas gingivalis
  • cut-off value
  • fingertip blood
  • multicenter trials
  • periodontopathic bacteria
  • screening test

ASJC Scopus subject areas

  • Dentistry(all)


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