Assessment of swallowing in motor neuron disease and Asidan/SCA36 patients with new methods

Nobutoshi Morimoto, Toru Yamashita, Kota Sato, Tomoko Kurata, Yoshio Ikeda, Toshimasa Kusuhara, Naomichi Murata, Koji Abe

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: We report on a unique complication of cerebellar ataxia and motor neuron disease named Asidan/SCA36 with a high frequency of tongue atrophy. We aimed to elucidate dysphagia in amyotrophic lateral sclerosis (ALS) and spinal, bulbar muscular atrophy (SBMA), and Asidan/SCA36 patients with new methods. Methods: Patients diagnosed with ALS (n = 20), SBMA (n = 6), and Asidan (n = 12) were included. A videofluoroscopic swallow study (VFS), an assessment of maximal tongue pressure (MTP), and impedance pharyngography (IPG) were applied. Results: The frequencies of VFS abnormalities were 70%, 50%, and 33% in ALS, SBMA, and Asidan/SCA36, respectively. Compared with control subjects (31.6 ± 6.3 kPa, mean ± SD), MTP was significantly decreased in ALS patients and SBMA patients, but was relatively preserved in Asidan patients. ALS patients performed more swallowing actions (Ns) detected by IPG than did control subjects, but SBMA and Asidan/SCA36 patients performed similar Ns to control subjects. Conclusions: VFS showed a higher frequency of swallowing abnormalities in ALS patients. MTP and IPG measurements showed the most severe involvement in ALS patients and a relatively preserved swallowing function in SBMA and Asidan/SCA36 patients.

Original languageEnglish
Pages (from-to)149-155
Number of pages7
JournalJournal of the Neurological Sciences
Volume324
Issue number1-2
DOIs
Publication statusPublished - Jan 15 2013

Fingerprint

Motor Neuron Disease
Deglutition
Atrophic Muscular Disorders
Amyotrophic Lateral Sclerosis
Tongue
Electric Impedance
Pressure
Cerebellar Ataxia
Deglutition Disorders
Atrophy

Keywords

  • Amyotrophic lateral sclerosis (ALS)
  • Asidan/SCA36
  • Impedance pharyngography (IPG)
  • Spinal and bulbar muscular atrophy (SBMA)

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Assessment of swallowing in motor neuron disease and Asidan/SCA36 patients with new methods. / Morimoto, Nobutoshi; Yamashita, Toru; Sato, Kota; Kurata, Tomoko; Ikeda, Yoshio; Kusuhara, Toshimasa; Murata, Naomichi; Abe, Koji.

In: Journal of the Neurological Sciences, Vol. 324, No. 1-2, 15.01.2013, p. 149-155.

Research output: Contribution to journalArticle

@article{b96b9dccd0994bb2b43a03fa9cb8c136,
title = "Assessment of swallowing in motor neuron disease and Asidan/SCA36 patients with new methods",
abstract = "Background: We report on a unique complication of cerebellar ataxia and motor neuron disease named Asidan/SCA36 with a high frequency of tongue atrophy. We aimed to elucidate dysphagia in amyotrophic lateral sclerosis (ALS) and spinal, bulbar muscular atrophy (SBMA), and Asidan/SCA36 patients with new methods. Methods: Patients diagnosed with ALS (n = 20), SBMA (n = 6), and Asidan (n = 12) were included. A videofluoroscopic swallow study (VFS), an assessment of maximal tongue pressure (MTP), and impedance pharyngography (IPG) were applied. Results: The frequencies of VFS abnormalities were 70{\%}, 50{\%}, and 33{\%} in ALS, SBMA, and Asidan/SCA36, respectively. Compared with control subjects (31.6 ± 6.3 kPa, mean ± SD), MTP was significantly decreased in ALS patients and SBMA patients, but was relatively preserved in Asidan patients. ALS patients performed more swallowing actions (Ns) detected by IPG than did control subjects, but SBMA and Asidan/SCA36 patients performed similar Ns to control subjects. Conclusions: VFS showed a higher frequency of swallowing abnormalities in ALS patients. MTP and IPG measurements showed the most severe involvement in ALS patients and a relatively preserved swallowing function in SBMA and Asidan/SCA36 patients.",
keywords = "Amyotrophic lateral sclerosis (ALS), Asidan/SCA36, Impedance pharyngography (IPG), Spinal and bulbar muscular atrophy (SBMA)",
author = "Nobutoshi Morimoto and Toru Yamashita and Kota Sato and Tomoko Kurata and Yoshio Ikeda and Toshimasa Kusuhara and Naomichi Murata and Koji Abe",
year = "2013",
month = "1",
day = "15",
doi = "10.1016/j.jns.2012.10.025",
language = "English",
volume = "324",
pages = "149--155",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Assessment of swallowing in motor neuron disease and Asidan/SCA36 patients with new methods

AU - Morimoto, Nobutoshi

AU - Yamashita, Toru

AU - Sato, Kota

AU - Kurata, Tomoko

AU - Ikeda, Yoshio

AU - Kusuhara, Toshimasa

AU - Murata, Naomichi

AU - Abe, Koji

PY - 2013/1/15

Y1 - 2013/1/15

N2 - Background: We report on a unique complication of cerebellar ataxia and motor neuron disease named Asidan/SCA36 with a high frequency of tongue atrophy. We aimed to elucidate dysphagia in amyotrophic lateral sclerosis (ALS) and spinal, bulbar muscular atrophy (SBMA), and Asidan/SCA36 patients with new methods. Methods: Patients diagnosed with ALS (n = 20), SBMA (n = 6), and Asidan (n = 12) were included. A videofluoroscopic swallow study (VFS), an assessment of maximal tongue pressure (MTP), and impedance pharyngography (IPG) were applied. Results: The frequencies of VFS abnormalities were 70%, 50%, and 33% in ALS, SBMA, and Asidan/SCA36, respectively. Compared with control subjects (31.6 ± 6.3 kPa, mean ± SD), MTP was significantly decreased in ALS patients and SBMA patients, but was relatively preserved in Asidan patients. ALS patients performed more swallowing actions (Ns) detected by IPG than did control subjects, but SBMA and Asidan/SCA36 patients performed similar Ns to control subjects. Conclusions: VFS showed a higher frequency of swallowing abnormalities in ALS patients. MTP and IPG measurements showed the most severe involvement in ALS patients and a relatively preserved swallowing function in SBMA and Asidan/SCA36 patients.

AB - Background: We report on a unique complication of cerebellar ataxia and motor neuron disease named Asidan/SCA36 with a high frequency of tongue atrophy. We aimed to elucidate dysphagia in amyotrophic lateral sclerosis (ALS) and spinal, bulbar muscular atrophy (SBMA), and Asidan/SCA36 patients with new methods. Methods: Patients diagnosed with ALS (n = 20), SBMA (n = 6), and Asidan (n = 12) were included. A videofluoroscopic swallow study (VFS), an assessment of maximal tongue pressure (MTP), and impedance pharyngography (IPG) were applied. Results: The frequencies of VFS abnormalities were 70%, 50%, and 33% in ALS, SBMA, and Asidan/SCA36, respectively. Compared with control subjects (31.6 ± 6.3 kPa, mean ± SD), MTP was significantly decreased in ALS patients and SBMA patients, but was relatively preserved in Asidan patients. ALS patients performed more swallowing actions (Ns) detected by IPG than did control subjects, but SBMA and Asidan/SCA36 patients performed similar Ns to control subjects. Conclusions: VFS showed a higher frequency of swallowing abnormalities in ALS patients. MTP and IPG measurements showed the most severe involvement in ALS patients and a relatively preserved swallowing function in SBMA and Asidan/SCA36 patients.

KW - Amyotrophic lateral sclerosis (ALS)

KW - Asidan/SCA36

KW - Impedance pharyngography (IPG)

KW - Spinal and bulbar muscular atrophy (SBMA)

UR - http://www.scopus.com/inward/record.url?scp=84870901869&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870901869&partnerID=8YFLogxK

U2 - 10.1016/j.jns.2012.10.025

DO - 10.1016/j.jns.2012.10.025

M3 - Article

C2 - 23146615

AN - SCOPUS:84870901869

VL - 324

SP - 149

EP - 155

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

IS - 1-2

ER -