Assessment of outcomes and differences between in- and out-of-hospital cardiac arrest patients treated with cardiopulmonary resuscitation using extracorporeal life support

Eisuke Kagawa, Ichiro Inoue, Takuji Kawagoe, Masaharu Ishihara, Yuji Shimatani, Satoshi Kurisu, Yasuharu Nakama, Kazuoki Dai, Otani Takayuki, Hiroki Ikenaga, Yoshimasa Morimoto, Kentaro Ejiri, Nozomu Oda

Research output: Contribution to journalArticlepeer-review

159 Citations (Scopus)

Abstract

Aim: Cardiopulmonary resuscitation (CPR) using extracorporeal life support (ECLS) for in-hospital cardiac arrest (IHCA) patients has been assigned a low-grade recommendation in current resuscitation guidelines. This study compared the outcomes of IHCA and out-of-hospital cardiac arrest (OHCA) patients treated with ECLS. Methods: A total of 77 patients were treated with ECLS. Baselines characteristics and outcomes were compared for 38 IHCA and 39 OCHA patients. Results: The time interval between collapse and starting ECLS was significantly shorter after IHCA than after OHCA (25 (21-43). min versus 59 (45-65). min, p< 0.001). The weaning rate from ECLS (61% versus 36%, p= 0.03) and 30-day survival (34% versus 13%, p= 0.03) were higher for IHCA compared with OHCA patients. IHCA patients had a higher rate of favourable neurological outcome compared to OHCA patients, but the difference was not statistically significant (26% versus 10%, p= 0.07). Kaplan-Meier analysis showed improved 30-day and 1-year survival for IHCA patients treated with ECLS compared to OHCA patients who had ECLS. However, multivariate stepwise Cox regression model analysis indicated no difference in 30-day (odds ratio 0.94 (95% confidence interval 0.68-1.27), p= 0.67) and 1-year survival (0.99 (0.73-1.33), p= 0.95). Conclusion: CPR with ECLS led to more favourable patient outcomes after IHCA compared with OHCA in our patient group. The difference in outcomes for ECLS after IHCA and OHCA disappeared after adjusting for patient factors and the time delay in starting ECLS.

Original languageEnglish
Pages (from-to)968-973
Number of pages6
JournalResuscitation
Volume81
Issue number8
DOIs
Publication statusPublished - Aug 2010
Externally publishedYes

Keywords

  • Cardiac arrest
  • Extracorporeal cardiopulmonary resuscitation
  • Extracorporeal life support
  • Extracorporeal membrane oxygenation
  • Percutaneous cardiopulmonary bypass

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency
  • Cardiology and Cardiovascular Medicine

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