To investigate hemorheological alterations during pregnancy, erythrocyte deformability was measured by the electron spin resonance (ESR) method in 10 women with uncomplicated pregnancy, 7 pre-eclamptic patients, and 10 non-pregnant controls. Erythrocyte deformability decreased significantly during pregnancy, and recovered to the non-pregnant control level on puerperal day 7. Deformability was significantly lower in the pre-eclampsia group than in the normal pregnancy group. In addition, erythrocyte deformability increased significantly when isoxsuprine or α-tocopherol were added to red cells suspensions of either the normal pregnancy or pre-eclampsia group. These data suggest the possibility of administration of isoxsuprine or α-tocopherol to increase erythrocyte deformability and improve placental perfusion.
|Number of pages||6|
|Journal||International Journal of Feto-Maternal Medicine|
|Publication status||Published - 1992|
- erythrocyte deformability
ASJC Scopus subject areas
- Obstetrics and Gynaecology