Abstract
To investigate hemorheological alterations during pregnancy, erythrocyte deformability was measured by the electron spin resonance (ESR) method in 10 women with uncomplicated pregnancy, 7 pre-eclamptic patients, and 10 non-pregnant controls. Erythrocyte deformability decreased significantly during pregnancy, and recovered to the non-pregnant control level on puerperal day 7. Deformability was significantly lower in the pre-eclampsia group than in the normal pregnancy group. In addition, erythrocyte deformability increased significantly when isoxsuprine or α-tocopherol were added to red cells suspensions of either the normal pregnancy or pre-eclampsia group. These data suggest the possibility of administration of isoxsuprine or α-tocopherol to increase erythrocyte deformability and improve placental perfusion.
| Original language | English |
|---|---|
| Pages (from-to) | 133-138 |
| Number of pages | 6 |
| Journal | International Journal of Feto-Maternal Medicine |
| Volume | 5 |
| Issue number | 3 |
| Publication status | Published - 1992 |
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Keywords
- α-tocopherol
- erythrocyte deformability
- isoxsuprine
- pre-eclampsia
ASJC Scopus subject areas
- Obstetrics and Gynaecology